Navigation Links
Preliminary Data from Ongoing Phase 1 Data of Investigational Anti-PD-1 Antibody Presented at American Society of Clinical Oncology Annual Meeting
Date:6/2/2008

PRINCETON, N.J., June 2 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX) today announced preliminary data from an ongoing Phase 1 study of MDX-1106 (ONO-4538: development code of Ono Pharmaceutical Co., Ltd.), a fully human anti-PD-1 antibody. Data presented from patients with recurrent or treatment-refractory cancer in the study included the safety, tolerability and pharmacokinetic profile of single-dose MDX-1106. In addition, preliminary evidence of anti-tumor activity was observed, including one patient with colorectal carcinoma who experienced a confirmed partial response that has been durable for more than 6 months. Tumor regressions (tumor shrinkage that did not meet the criteria for partial response) were also observed in four additional patients, including two patients with melanoma, one patient with non-small cell lung cancer, and one with renal cell carcinoma. These preliminary study results were presented in an oral presentation by investigator Julie Brahmer, M.D., Assistant Professor of Oncology from the Sidney Kimmel Cancer Comprehensive Center at Johns Hopkins University at the annual meeting of the American Society of Clinical Oncology (ASCO) being held in Chicago. (Abstract #3006)

"We are pleased with the safety profile and preliminary evidence of anti- tumor activity from this first human clinical trial of MDX-1106," said Geoffrey M. Nichol, MBChB, Senior Vice President of Product Development at Medarex. "We look forward to the further development of this novel immunotherapy, and plans are underway to initiate a Phase 2 trial of MDX-1106 in cancer this year."

In the single-dose Phase 1 trial, 24 patients initially enrolled in the dose-escalation portion of the trial, and an additional 15 patients are n
'/>"/>

SOURCE Medarex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer
2. Strativa Pharmaceuticals Announces Preliminary Results from ONCONASE(R) Phase IIIb Clinical Trial
3. Alfacell Corporation Announces Preliminary Results From ONCONASE(R) Phase IIIb Clinical Trial
4. Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations
5. Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa
6. MitraClip Device Preliminary Data Suggests Improved Heart Function and Relief from Heart Failure Symptoms in Functional Mitral Regurgitation Patients
7. Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies
8. NeurogesX Announces Preliminary Results from Second Phase 3 Clinical Trial in HIV-DSP
9. MacuSight(TM) Announces Positive Preliminary Results From Phase 1 Study of Sirolimus in Wet Age-Related Macular Degeneration
10. Preliminary PI-88 Phase 2 Prostate Cancer Results to be Presented at the American Society for Clinical Oncology (ASCO) 2008 Genitourinary Cancer Symposium
11. A Functional Immune System Can Be Derived From Embryonic Stem Cells, Preliminary Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 ... ;  Sorrento), an oncology company developing new treatments ... a privately-held immuno-oncology company developing proprietary Neukoplast ® ... therapy, announced today that the companies have entered ... generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the ...
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... States will increase to a value of ... driven by expansion in the large direct energy device ... be increasingly adopted due to the advantages they offer ... key findings from Decision Resources Group,s coverage of the ...
(Date:12/19/2014)... CITY, Kan. , Dec. 18, 2014 /PRNewswire/ ... PETX ), a biopharmaceutical company focused on the ... companion animals, today announced positive results from its ... innovative drug for treating pain in dogs with ... improvements in pain assessment scores that were statistically ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
... Inc. (Soligenix or the Company) (OTC BB: SNGX), a ... its North American licensing partnership with Sigma - Tau ... commercialization of orBec® (oral beclomethasone dipropionate or Oral BDP) ... the amended agreement, Sigma - Tau has made a ...
... SAN DIEGO, July 28, 2011 Cardium Therapeutics (NYSE Amex: ... plan to acquire substantially all of Transdel Pharmaceuticals, business assets ... of the U.S. Bankruptcy Code. As described on June 27, ... to a number of conditions, including approval of the bankruptcy ...
Cached Medicine Technology:Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 2Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 3Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 4Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 5Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 6Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 7Soligenix Announces Expansion of Partnership With Sigma-Tau Pharmaceuticals for orBec® in Europe 8Cardium Reports on Transdel Transaction 2Cardium Reports on Transdel Transaction 3Cardium Reports on Transdel Transaction 4
(Date:12/20/2014)... LunaDress has recently announced its 2015 collection of ... on all of its special occasion dresses & wedding apparel. ... wedding gown. If you have no idea of what to ... different wedding dress styles and our dress experts are here ... current special offer, up to 80% off," the CEO of ...
(Date:12/20/2014)... The print component of Healthy Aging is distributed ... 160,000 copies and an estimated readership of 420,000. The ... media strategy and across a network of top news ... of the campaign, click here . , The ... of CTV’s The Social. Lainey Lui, Melissa Grelo, ...
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress ... Sale Online for 2015. Great discounts are now ... old consumers can get a discount, up to 80% ... website before January 30, 2015. , VogueQueen.com has recently ... a prom dress promotion. Many customers worldwide like VogueQueen’s ...
(Date:12/20/2014)... December 20, 2014 Angeldress.co.uk, the distinguished ... great for worldwide dress fans. The company has recently ... and information. For the holiday season, Angeldress Blog ... special wedding apparel. , Angeldress.co.uk prides itself in offering ... level of service. All the company’s outfits are very ...
(Date:12/20/2014)... 20, 2014 Atore, Inc, (San Francisco, ... launched first birthday focused portal on December 17th, 2014. ... launched in both US and Japan. , MERRY BIRTHDAY ... http://merrybirthday.net/message/ , MERRY BIRTHDAY MESSAGE is part ... the world. , Features, Choose from thousands of stock ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Atore, Inc. Releasing the First Birthday Portal 2
... ... IBM ) today announced that its lending arm, IBM Global ... healthcare records (EHR) providers, highlighting the growing need for private financing ... face to adopt health IT solutions. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090416/IBMLOGO ...
... , RANCHO SANTA FE, Calif., Dec. 22 ... checking them twice, Helen Woodward Animal Center (HWAC) began a quest ... Puerto Rico,s Canita Animal Sanctuary the HWAC team from Rancho Santa ... the largest Humane Society facility on the island only three of ...
... , ... 22 /PRNewswire-Asia/ -- Avery Dennison Specialty Tape has,developed a proprietary ... Its newest generation of ultra-thin hydrocolloid,adhesives delivers real consumer benefits ... skin softening beneath the dressing, and,gentle removal. , ...
... ... effective in the alleviation of symptoms associated with many chronic conditions such as allergies, ... 300 practices throughout the country are using this holistic therapy including over 50 branded ... ...
... Make your New ... for 2010. So says Australian weight loss and dieting researcher, Mr Trevor Johnson. With an epidemic ... new year,s weight loss resolutions fail within the first week. The primary cause of the failure ... (PRWEB) ...
... study published in the January issue of Radiology , ... MRI declined to undergo the procedure. "Given that ... early breast cancer, we were surprised that barely half of ... even when offered at no cost," said Wendie A. Berg, ...
Cached Medicine News:Health News:IBM Financing Agreements With Electronic Healthcare Record Providers Shatter Barriers To Health IT Adoption 2Health News:IBM Financing Agreements With Electronic Healthcare Record Providers Shatter Barriers To Health IT Adoption 3Health News:IBM Financing Agreements With Electronic Healthcare Record Providers Shatter Barriers To Health IT Adoption 4Health News:IBM Financing Agreements With Electronic Healthcare Record Providers Shatter Barriers To Health IT Adoption 5Health News:While Some Were Counting Sugar Plums...Others Were Changing the Future 2Health News:Avery Dennison Innovates in Consumer Wound Care 2Health News:Avery Dennison Innovates in Consumer Wound Care 3Health News:BioVeda Health and Wellness Center of Nampa, ID Announces its Grand Opening 2Health News:BioVeda Health and Wellness Center of Nampa, ID Announces its Grand Opening 3Health News:BioVeda Health and Wellness Center of Nampa, ID Announces its Grand Opening 4Health News:BioVeda Health and Wellness Center of Nampa, ID Announces its Grand Opening 5Health News:Making New Year's Resolution Today is Key to 2010 Weight Loss & Dieting Success 2Health News:Elevated-risk women refuse MRI breast cancer screening 2
... DBM Matrix PLF is ... material designed specifically for ... trough-like design allows for ... bone. Demineralized bone fibers ...
Demineralized bone matrix dispensed in a syringe. DBM will be free of foreign matter. Demineralized bone matrix particle size 125 to 850 . Glycerol 70-88% by weight. Calcium content less than 8%....
... Olympus' new generation Endoalpha is a centralized ... surgeon and the nurse by giving them ... Endoalpha provides protection against obsolescence, as future ... than the purchase of an entirely new ...
... systems two-piece design provides maximum positioning flexibility while ... for safe storage and easy transport. The system ... of floor space, but at the same time ... sterile field. Both the camera and display of ...
Medicine Products: