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Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients
Date:6/2/2008

ytarabine (Ara-C) to cytarabine alone.

A second phase 3 study of clofarabine sponsored by the Eastern Cooperative Oncology Group is expected to begin enrolling patients next year. This study will compare single agent clofarabine to conventional induction chemotherapy in untreated AML patients age 60 and older who are considered suitable for conventional induction chemotherapy.

Clolar is indicated for the treatment of pediatric patients 1 to 21 years old with relapsed or refractory ALL after at least two prior regimens. This use is based on the induction of complete responses. Randomized trials demonstrating increased survival or other clinical benefit have not been conducted.

Genzyme also is actively exploring additional therapeutic indications for Clolar, including in MDS.

Genzyme Hosts Investor Call Tomorrow Morning

Genzyme will host an investor call tomorrow morning, Tuesday, June 3 at 10 a.m. EST. The preliminary data from the CLASSIC-II pivotal study will be reviewed and there will be opportunity for investors to ask questions of Genzyme.

To participate in the call, please dial 1-888-982-7287 in the U.S. or 1-210-234-0251 outside of the U.S. The participant passcode is "Genzyme."

A replay of this call will be available by dialing 1-800-695-3397. This call will also be available live on the investor events section of http://www.genzyme.com. Replays of the call will be available until 10:59 p.m. on June 10, 2008.

About Clolar

Clolar has Orphan Drug designation for adult and pediatric ALL, and seven years of market exclusivity in the United States for relapsed/refractory pediatric ALL. The FDA also granted six months of extended market exclusivity to Clolar under the Best Pharmaceuticals for Children Act.

Clolar should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Suppression of
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SOURCE Genzyme Corp.
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