Navigation Links
Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients
Date:6/2/2008

istered as 30mg/m2 per day for five consecutive days then, based on their response, received up to five additional cycles of treatment at a dose of 20 mg/m2 per day for five consecutive days.

Significant Unmet Medical Need

The CLASSIC II study is designed to address a high unmet medical need among older AML patients who currently have limited treatment options. According to the American Cancer Society, each year approximately 6,500 people over the age of 60 are diagnosed with AML in the U.S. The median survival for those receiving therapy can vary from one to thirteen months, and the five-year survival rate over the past three decades remains at less than 10 to 15 percent. Older AML patients often have disease features such as unfavorable (adverse) cytogenetics and pre-existing blood disorders such as MDS that result in lower response rates and worse treatment outcomes to conventional induction chemotherapy compared with younger patients. In addition, conventional induction chemotherapy is poorly tolerated in older patients with unfavorable risk factors, and early induction mortality usually ranges from 10-30 percent but can exceed 30 percent in older patients with a poor performance status.

This study builds on promising results from two prior studies of single agent clofarabine in previously untreated older patients with AML deemed unfit for chemotherapy, based mostly on poor performance status and presence of co-morbid illnesses. These studies were conducted by Alan Burnett, M.D., of Cardiff University in the United Kingdom and presented at earlier American Society of Hematology meetings.

Clolar Clinical Development

A separate, phase 3 pivotal study (CLASSIC I) of clofarabine in relapsed adult AML patients aged 55 and older and previously treated with at least one, but not more than two, prior induction regimens is underway. This randomized, double-blind, placebo-controlled study will compare the combination of clofarabine and c
'/>"/>

SOURCE Genzyme Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Genomic Health Announces Preliminary Results From a Study of Oncotype DX(TM) in Node-Positive Breast Cancer Patients
3. Preliminary Results of Randomized Pilot Study Show Comparable Efficacy for OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) and Boston Scientifics Taxus(R) Stent in Patients at High Risk of Restenosis
4. Sunesis Pharmaceuticals Reports Preliminary SNS-595 Activity in Ovarian Cancer Clinical Trial at AACR-NCI-EORTC International Conference
5. Pharmion and MethylGene Report Preliminary MGCD0103 Clinical Data at the 2007 AACR-NCI-EORTC International Conference
6. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
7. Vion Pharmaceuticals To Present Preliminary Data on its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) at the American Society of Hematology Meeting
8. Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting
9. Anthera Announces Preliminary Positive Results From Once-Daily A-002 Phase II Cardiovascular Trial
10. Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX-4 in Allergic Rhinitis Patients
11. A Functional Immune System Can Be Derived From Embryonic Stem Cells, Preliminary Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014 The Competitive Intelligence (CI) function ... changes. CI leaders who adjust will succeed, and those ... new Best Practices, LLC study CI leaders from 32 ... - Use secondary research whenever possible - ... - Internal staff who are creative thinkers provide ...
(Date:8/29/2014)... Mass. , Aug. 29, 2014  A ... prospective, multinational study on stent removability and preliminary ... has been published in the August issue of ... multinational study 1 is being conducted in ... of fully covered self-expanding metal stents (FCSEMS) after ...
(Date:8/29/2014)... Calif. , Aug. 29, 2014 Thoratec ... in device-based mechanical circulatory support therapies to save, support ... participating in the 2014 Morgan Stanley Global Healthcare Conference ... Burbach , President and Chief Executive Officer, will provide ... Eastern Daylight Time (9:55 a.m., Pacific Daylight Time).   ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... NEW YORK, Dec. 13, 2011 ... research report is available in its ... Imaging Equipment Market Outlook in BRICS ... to 2017 ...
... 2011 -- Breadth of Pharmacokinetic Data ... Pieris AG presented novel preclinical in vitro ... Anticalin hepcidin antagonist in an oral presentation at the ... today.  In a presentation entitled "Discovery and Preclinical Characterization ...
Cached Medicine Technology:Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 2Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 3Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 4Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 5Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 6Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 7Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 8Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 9Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 10Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 11Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 12Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 13Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 14Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 15Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 16Nuclear Imaging Equipment Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 17Pieris Presents Preclinical Data for PRS-080 Hepcidin Antagonist Anticalin(R) Program at ASH Annual Meeting 2Pieris Presents Preclinical Data for PRS-080 Hepcidin Antagonist Anticalin(R) Program at ASH Annual Meeting 3
(Date:8/30/2014)... 2014 LiveStreamingFitness.com, a company dedicated to providing ... lifestyle resources, is proud to announce it has been recognized ... home fitness solutions by ABC’s Good Morning America. ... ABC’s Good Morning America, “Live Streaming Fitness is the hottest ... day by streamlining your workout…to boot camp at Life Streaming ...
(Date:8/30/2014)... 2014 When a prominent bank reveals a ... on Wednesday, August 27th, when news began surfacing about the ... & Co and at least one other bank. But ... investigating attacks on seven prominent banks , everyone starts thinking ... and the buzz quickly goes viral. Bloomberg followed up ...
(Date:8/30/2014)... 30, 2014 Final Cut Pro ... the TransGhost plugin from Pixel Film Studios. , “The ... the ability to tell their scary story in a ... Studios. “Users will make their audience scream with this ... With TransGhost users can awaken evil spirits with over ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 The SI ... nine mobilizations and six muscle energy techniques. Michael P. ... and demonstrates twenty-seven examination techniques for the SI Joint. ... supports Dr. Reiman's live course presentation with North American ... Applying a differential diagnosis approach to ...
(Date:8/30/2014)... The KSF (Kung Fu Sanshou Federation) ... on November 8th, 2014 at the Mobile Civic Center ... introduced many notorious and notable fighters for some top ... UFC. , Among these KSF along with the ... armed with the virtues of true indomitable Shaolin spirit, ...
Breaking Medicine News(10 mins):Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 2Health News:Pixel Film Studios Released TransGhost Plugin for Final Cut Pro X Today 3Health News:North American Seminars Online PT Continuing Education Course, Examination and Treatment of the SI Joint, Receives Continuing Education Approval in NJ, CA, IL, PA, & TX 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 2Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 3Health News:KSF Presents US Open Challenge-K. Warrior Search, Seeking Inspirational Warrior Fighters Like Cung Le 4
... The 23rd annual conference of the European Society of ... promising new therapy for protecting the fertility of women ... ,Dr. Kate Stern, Research Director of the ... her pilot study had shown gonadotropin-releasing hormone (GnRH) antagonists ...
... The Australian drug delivery company, announced positive results ... contraceptive skin sprays, each containing a progestin and an ... Phase I, pharmacokinetic study, investigating the delivery of a ... A single dose of the combination formulation was applied ...
... killed his 25-year-old female neighbor was sentenced to life in prison. ... Sylvester was described as an act of extreme cruelty and ... sentence with no chance of parole for at least 16 years. ... May of second-degree murder in the death of Alicia Ross, intended ...
... scientists have developed a new minimally invasive method ... clinical trials on individuals with prostate cancer soon ... called irreversible electroporation (IRE) is a result of ... Davalos and University of California bioengineering professor Boris ...
... the Kennedy Krieger Institute recognize children with autism earlier ... and improved outcomes . ,In a study ... from the Kennedy Krieger Institute in Baltimore, Maryland found ... year of age, which is the earliest the disorder ...
... microRNA company, announced today research published in the journal ... Science and Rosetta Genomics . The findings suggest the ... used as a drug candidate in cancer therapy to ... potent tumor suppressor p53. ,p53 has been ...
Cached Medicine News:Health News:A New Therapy to Protect Cancer Patients Against Infertility 2Health News:Contraceptive Spray Shows Positive Clinical Trial Result 2Health News:A Savage Murderer in Canada Gets Sentenced to Life 2Health News:Scientists Destroy Cancer Cells Using Electric Pulses 2Health News:Autism Children can Be Diagnosed Within One Year of Age 2Health News:Autism Children can Be Diagnosed Within One Year of Age 3Health News:Autism Children can Be Diagnosed Within One Year of Age 4Health News:Role of MicroRNA in Cancer Suppression Identified 2
... Enzymatic Foam is the ready-to-use, pre-cleaning enzymatic ... rubber. ,Hemaway Enzymatic Foam sprays ... corrosion. It's perfect for use in the ... available. Getting a head start with Hemaway ...
... is the low-foaming detergent and non-silicone lubricant ... pressurized washers. Duo-Klenz removes blood ... surgical instruments. Highly concentrated, low-foaming Duo-Klenz ... lubricating surgical instruments -- all in one ...
... Finger Traps grip the patients finger snugly. Wrap ... a Stainless Steel Finger Trap for an extra ... Finger traps create a complete upper extremity traction ... or ISI Advanced Universal K Table. Stainless Steel ...
... Traps for optimum patient comfort. The Nylon Finger ... a firm grip. ISI Nylon Finger Traps create ... used with the ISI Digi Grip or ISI ... are available in non-sterile packs and come in ...
Medicine Products: