Navigation Links
Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients
Date:6/2/2008

ed Harry P. Erba, MD, Ph.D., University of Michigan, one of the co-principal investigators for this study. "This study helps to define a new approach to treatment for patients unlikely to benefit from conventional 7+3 induction chemotherapy and provides support for the importance of assessing cytogenetics prior to induction treatment."

"The positive results seen in this study provide a compelling case for a novel, effective, therapeutic option for older adult patients with AML who have multiple unfavorable prognostic factors," added Hagop Kantarjian, M.D. MD Anderson Cancer Center and the other co-principal investigator for the CLASSIC II study. "In our published research from MD Anderson, older AML patients with one to three unfavorable prognostic factors are at risk of lower complete remission rates and higher 60-day mortality. We look forward to analyzing the final independently-assessed study results, particularly the remission duration data, for this very difficult-to-treat population."

In addition to presentation at ASCO, a podium appearance of the preliminary CLASSIC-II data also will be delivered by Dr. Erba at the upcoming European Hematology Association meeting in Copenhagen, Denmark on Sunday, June 15.

Study Design

Patients in the CLASSIC-II study must have previously untreated AML, be 60 years or older and be unlikely to benefit from conventional induction chemotherapy based on the presence of at least one of the following adverse prognostic factors: age greater than or equal to 70, pre-existing hematological disorder such as myelodysplastic syndrome (MDS), poor health performance, or intermediate or unfavorable cytogenetics. Patients also had to be previously untreated and unlikely to benefit from conventional induction chemotherapy (7+3 anthracycline plus cytarabine) based on the presence of at least one of these poor prognostic factors at baseline.

Patients received an induction cycle of intravenous clofarabine admin
'/>"/>

SOURCE Genzyme Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Genomic Health Announces Preliminary Results From a Study of Oncotype DX(TM) in Node-Positive Breast Cancer Patients
3. Preliminary Results of Randomized Pilot Study Show Comparable Efficacy for OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) and Boston Scientifics Taxus(R) Stent in Patients at High Risk of Restenosis
4. Sunesis Pharmaceuticals Reports Preliminary SNS-595 Activity in Ovarian Cancer Clinical Trial at AACR-NCI-EORTC International Conference
5. Pharmion and MethylGene Report Preliminary MGCD0103 Clinical Data at the 2007 AACR-NCI-EORTC International Conference
6. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
7. Vion Pharmaceuticals To Present Preliminary Data on its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) at the American Society of Hematology Meeting
8. Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting
9. Anthera Announces Preliminary Positive Results From Once-Daily A-002 Phase II Cardiovascular Trial
10. Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX-4 in Allergic Rhinitis Patients
11. A Functional Immune System Can Be Derived From Embryonic Stem Cells, Preliminary Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces ... in its catalogue: Global Animal Health ... About Animal Health Animal health refers ... or treat animals to enhance their quality of ... of animal food. The Global Animal Health market ...
(Date:8/27/2014)... Kewaunee Scientific Corporation (Nasdaq: KEQU ... quarterly cash dividend by 9% to twelve cents per ... with the dividend payable on September 22, 2014 to ... September 8, 2014. About Kewaunee Scientific ... Corporation is a recognized global leader in the design, ...
(Date:8/27/2014)... , Aug. 27, 2014  UBM Medica US announces ... online community for medical imaging professionals, presents special reporting ... Medical Imaging Management,s 2014 Annual Meeting . ... , 11 Principles of Successful Labor ... to greater profitability. , Why Don,t Patients ...
Breaking Medicine Technology:Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7Diagnostic Imaging Covers Association for Medical Imaging Management (AHRA) 2014 Meeting 2Diagnostic Imaging Covers Association for Medical Imaging Management (AHRA) 2014 Meeting 3
... and INDIANAPOLIS, Ind., May 5 A new substudy from ... showed that patients who took prasugrel and had a reduced ... risk of cardiovascular death, heart attack or stroke compared with ... were published online in Circulation on May 4, ...
... Oramed Pharmaceuticals, Inc.,(OTC: ORMP) ( http://www.oramed.com ), a ... clinical trials will commence this week on 30 ... evaluate the safety,tolerability and efficacy of its oral ... (CRO) located in Johannesburg,South Africa, will oversee the ...
Cached Medicine Technology:New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel 2New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel 3New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel 4New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel 5Oramed Pharmaceuticals Announces Launch of Phase 2B Clinical Trials in South Africa of its Oral Insulin Capsule 2
(Date:8/27/2014)... last things a parent wants to deal with, but ... a week old. , Skin that turns yellow can ... and isn,t adequately eliminating the chemical bilirubin. But that ... left untreated can harm a baby. , University of ... that checks for jaundice in newborns and can deliver ...
(Date:8/27/2014)... last time you experienced worrisome medical symptoms, did ... health-care professional? If so, you,re not alone. Consumers ... peer support groups to gather anecdotal information and ... and trustworthy sources. New research to be presented ... studies the characteristics of consumers who use the ...
(Date:8/27/2014)... 2014 For nearly two decades, audiences ... beloved mantra singers Deva Premal & Miten with their ... of their latest album in May, their 2014 MANTRAS ... countries around the globe, including Russia, Ukraine, Israel, Australia, ... Europe. With a new album and a new five-piece ...
(Date:8/27/2014)... BESLER Consulting , a leading provider ... is pleased to announce that it has been named ... Companies. The list represents the most comprehensive look at ... , "It's been an exciting year for our company ... year's Inc. 5000 list,” said Jonathan Besler, BESLER’s President ...
(Date:8/27/2014)... Home Care Assistance of Scottsdale , a ... to announce the next installment in its renowned Healthy ... Suzanne Steinbaum, attending cardiologist and Director of Women’s Heart ... National Spokesperson for the American Heart Association’s Go Red ... surrounding women and heart disease, what heart disease is ...
Breaking Medicine News(10 mins):Health News:New smartphone app can detect newborn jaundice in minutes 2Health News:New smartphone app can detect newborn jaundice in minutes 3Health News:Educated consumers more likely to use potentially unreliable online healthcare information 2Health News:Deva Premal & Miten's Mantras For Life Tour Announced 2Health News:Deva Premal & Miten's Mantras For Life Tour Announced 3Health News:BESLER Consulting Among America’s Fastest Growing Private Companies 2Health News:Home Care Assistance of Scottsdale to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Scottsdale to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3
... the most comprehensive analyses yet done of the ancient history ... is not only native to the New World, but it ... evolved through birds and monkeys. The findings, presented ... researchers from Oregon State University, are based on the study ...
... HealthDay Reporter , WEDNESDAY, Nov. 2 (HealthDay News) -- Obese ... going about it in the most healthy or effective ways, ... teens trying to drop the pounds don,t seem to ... of nearly 44,000 adolescents who participated in the Philadelphia ...
... of the population of Denmark. The figure has been on ... Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), University of ... "In our study of over 400 children we ... in their rectums and the risk of development of allergic ...
... Cancer cells maintain their life-style of extremely rapid growth and ... that alters the cells, ability to metabolize glucose a ... Krainer, Ph.D., and his team at Cold Spring Harbor Laboratory ... cells to regain the metabolism of normal cells, have discovered ...
... at Wayne State University,s Parent Health Lab in the ... that identifies women at risk for drug use by ... use itself. In phase I testing, this new screener ... at detecting recent drug use. The team of researchers ...
... combined with physical activity can help to improve some of ... The study, which is published online in the European ... can have on obese people with sleep apnoea, compared to ... syndrome (OSAS) causes frequent pauses of breathing to occur during ...
Cached Medicine News:Health News:Analysis reveals malaria, other diseases as ancient, adaptive and persistent foes 2Health News:Analysis reveals malaria, other diseases as ancient, adaptive and persistent foes 3Health News:Overweight Teens Don't Seem to Grasp Weight Loss Rules 2Health News:Overweight Teens Don't Seem to Grasp Weight Loss Rules 3Health News:Dirt prevents allergy 2Health News:Study reveals details of alternative splicing circuitry that promotes cancer's Warburg effect 2Health News:Wayne State creating computer-based drug intervention for at-risk post-partum women 2Health News:Mediterranean diet and exercise can reduce sleep apnea symptoms 2
... (Penicillin G) inhibits bacterial ... synthesis. Streptomycin belongs to ... inhibits bacterial growth by ... is used for prevention ...
...
Contains 10,000 units of penicillin (base), 10,000 g of streptomycin (base), and 25 g of amphotericin B/ml utilizing penicillin G (sodium salt), streptomycin sulfate, and amphotericin B as Fungizone ...
All BioWhittaker Cell Culture Reagent and Buffer products are manufactured in accordance with cGMP regulations and are cell culture tested to assure compatibility. , Typical Properties, Sterility : ...
Medicine Products: