Navigation Links
Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients
Date:6/2/2008

ta show a 45 percent overall remission rate among patients treated with single agent clofarabine, with 40 percent of patients achieving a complete remission to therapy and 5 percent attaining a complete remission with incomplete platelet recovery. Overall remission in this study is defined as a patient achieving either complete remission or complete remission with incomplete platelet recovery. Secondary endpoints include duration of remission, disease free survival, overall survival, safety and thirty-day mortality. The CLASSIC II study data are based on clinical responses from 115 patients at 20 sites in the U.S.

Data also show overall remission rates of 50 percent among patients with prior blood disorders; 43 percent in patients with adverse cytogenetics; 40 percent in patients 70 years of age and older; and 38 percent in patients with an ECOG performance status of 2. Remission rates in patients with up to three pre-defined risk factors required for study enrollment also exceeded 40 percent.

The study also demonstrated that the toxicity profile of clofarabine was predictable and manageable. Drug-related adverse events occurring in more than 15 percent of patients included nausea, febrile neutropenia, vomiting, diarrhea and rash; most were grade 1 or 2. As expected, Grade 4 neutropenia and thrombocytopenia occurred in a majority of patients. Only five of 115 patients discontinued treatment due to an adverse event or toxicity precluding further therapy. The study has completed enrollment and patients are being followed for remission duration, disease-free survival and overall survival. An independent panel of hematologists and hematopathologists are confirming the investigators' assessment of responses.

"In addition to the excellent overall safety and efficacy findings we are observing with single agent clofarabine, we also see impressive responses in older patients with poor prognostic cytogenetic abnormalities when treated with the drug," stat
'/>"/>

SOURCE Genzyme Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Genomic Health Announces Preliminary Results From a Study of Oncotype DX(TM) in Node-Positive Breast Cancer Patients
3. Preliminary Results of Randomized Pilot Study Show Comparable Efficacy for OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) and Boston Scientifics Taxus(R) Stent in Patients at High Risk of Restenosis
4. Sunesis Pharmaceuticals Reports Preliminary SNS-595 Activity in Ovarian Cancer Clinical Trial at AACR-NCI-EORTC International Conference
5. Pharmion and MethylGene Report Preliminary MGCD0103 Clinical Data at the 2007 AACR-NCI-EORTC International Conference
6. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
7. Vion Pharmaceuticals To Present Preliminary Data on its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) at the American Society of Hematology Meeting
8. Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting
9. Anthera Announces Preliminary Positive Results From Once-Daily A-002 Phase II Cardiovascular Trial
10. Morria Biopharmaceuticals Plc Announces Preliminary Safety and Tolerability Results From Its Phase I Clinical Study of MRX-4 in Allergic Rhinitis Patients
11. A Functional Immune System Can Be Derived From Embryonic Stem Cells, Preliminary Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... 2015 This report analyzes the worldwide markets for ... following Segments: Standard Intraocular Lenses, and Premium Intraocular Lenses. The ... Canada , Japan , ... Latin America , and Rest of World. Annual estimates ... Also, a seven-year historic analysis is provided for these markets. ...
(Date:5/28/2015)... Calif. , May 28, 2015 Isis ... webcast:What: , Akcea Therapeutics WebcastWhen: , Thursday, June 4 ... www.isispharm.com How: , Live on the Internet.  Simply ... unable to participate during the live event, a replay ... time at www.isispharm.com . ABOUT ISIS ...
(Date:5/28/2015)... Texas , May 28, 2015   Lexicon ... that Lexicon management will present at the Jefferies 2015 ... a.m. Eastern Time in New York ... clinical development programs and milestones. A webcast ... at www.lexpharma.com . An archived version of the ...
Breaking Medicine Technology:World Intraocular Lenses Industry 2World Intraocular Lenses Industry 3World Intraocular Lenses Industry 4World Intraocular Lenses Industry 5World Intraocular Lenses Industry 6World Intraocular Lenses Industry 7World Intraocular Lenses Industry 8World Intraocular Lenses Industry 9World Intraocular Lenses Industry 10World Intraocular Lenses Industry 11World Intraocular Lenses Industry 12World Intraocular Lenses Industry 13World Intraocular Lenses Industry 14World Intraocular Lenses Industry 15World Intraocular Lenses Industry 16World Intraocular Lenses Industry 17World Intraocular Lenses Industry 18World Intraocular Lenses Industry 19World Intraocular Lenses Industry 20World Intraocular Lenses Industry 21World Intraocular Lenses Industry 22World Intraocular Lenses Industry 23World Intraocular Lenses Industry 24World Intraocular Lenses Industry 25World Intraocular Lenses Industry 26Webcast Alert: Akcea Therapeutics Conference Call 2Webcast Alert: Akcea Therapeutics Conference Call 3Lexicon To Present At The Jefferies 2015 Healthcare Conference 2
... July 19, 2011 Unilife Corporation ("Unilife" or the "Company") ... has commenced the initial sale of the Unifill® ready-to-fill syringe ... commencement of Unifill sales to this new customer, whose identity ... the device to Sanofi last week.  Unilife continues to expand ...
... 2011 MSC Care Management, a national leader in ... the workers, compensation industry, helps claims professionals save on ... bill management solution. By directing new and recurring transactions ... of MSC,s contracted rates with in-network providers, which are ...
Cached Medicine Technology:Unilife Starts Unifill Syringe Sales to Another Pharmaceutical Customer 2Unilife Starts Unifill Syringe Sales to Another Pharmaceutical Customer 3MSC CareSync+ Bill Management Maximizes Savings on Each Transaction 2
(Date:5/28/2015)... Bayonne, NJ (PRWEB) May 28, 2015 ... has announced an exclusive deal to patients looking ... From June 1 through 30, patients will be able ... an $800 procedure, for just $600. For a three-treatment ... a fourth treatment at no cost. , Dr. Juanita ...
(Date:5/28/2015)... 28, 2015 Ross A. Clevens, MD, ... has hired Teresa Beard as the new marketing director ... Beard will oversee all marketing and promotional events for ... leading teams and developing compelling marketing strategies to achieve ... Specialists, Beard served as guest communication manager at the ...
(Date:5/28/2015)... ISMETT , a leading transplant hospital ... Sicilian economy by €132.5 million in expenditure in 2013, generated ... than €73 million by retaining patients who otherwise would have ... study by the Battelle Memorial Institute. At the same time, ... advanced health care management that is transforming Sicily into a ...
(Date:5/28/2015)... 28, 2015 The CEO and Founder ... just launched blog series which provides analysis on the ... the “R. Bruce Dalglish” profile on Blogger.com, this instructive ... Dalglish’s corporate experience. , “Throughout my business career, ... have upon the overall success of businesses,” stated R. ...
(Date:5/28/2015)... 28, 2015 More than 300 locations ... raise money to help the Muscular Dystrophy Association save ... and related life-threatening diseases that limit muscle strength and ... program. , From June 1 to June 30, sweetFrog ... the opportunity to help send local children affected by ...
Breaking Medicine News(10 mins):Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 2Health News:Dr. Jenyons’ Medical Weight Loss & Rejuvenation Center Now Offering Skin Treatment Specials 3Health News:Clevens Face and Body Specialists Welcomes Teresa Beard as Marketing Director 2Health News:UPMC-Managed Transplant Hospital Drives Major Economic Benefits for Sicily, Study Finds 2Health News:UPMC-Managed Transplant Hospital Drives Major Economic Benefits for Sicily, Study Finds 3Health News:R. Bruce Dalglish, CEO of Alliance Hospice, Introduces New Blog Series On Positive Corporate Culture 2Health News:sweetFrog and MDA Join Forces to Send Kids with Muscle Disease to Summer Camp 2Health News:sweetFrog and MDA Join Forces to Send Kids with Muscle Disease to Summer Camp 3
... Willie Mays in the 1954 World Series as one of the greatest ... a puzzle: How does an outfielder get to the right place at ... of fans (and hundreds of thousands of YouTube viewers) saw Mays turn ... and catch the ball over his shoulder, seemingly a precise prediction of ...
... enzyme affects blood glucose levels in mice provides clues to ... of longevity and the proliferation of tumor cells. In ... , a Massachusetts General Hospital (MGH)-based team of researchers describes ... a fatal drop in blood sugar in mice by triggering ...
... with proteomic analyses of blood samples may help physicians ... many women, according to an article published in the ... . Proteomics is the study of proteins, particularly their ... fifth leading cause of cancer-related death. More than 21,500 ...
... sensor could provide fresh, inexpensive diagnosis and treatment methods ... University of Florida engineers have designed and tested versions ... glucose levels via their breath to detecting possible indicators ... are promising particularly considering that the sensor can ...
... The BC Centre for Disease Control has launched ... the pandemic H1N1 flu virus has evolved in British ... months. This project capitalizes on BC,s expertise and ... genomes from circulating influenza viruses collected in British Columbia ...
... , Housewife Hits South ... Lisa Wu Hartwell , one of the stars ...  is coming to Boca Raton, Florida .   She isn,t ... of millions of viewers. , (Photo: http://www.newscom.com/cgi-bin/prnh/20100120/DC41252 ) , (Logo: ...
Cached Medicine News:Health News:How does an outfielder know where to run for a fly ball? 2Health News:Lack of cellular enzyme triggers switch in glucose processing 2Health News:Lack of cellular enzyme triggers switch in glucose processing 3Health News:Ultrasound plus proteomic blood analyses may help physicians diagnose early-stage ovarian cancer 2Health News:Engineers: New sensor could help treat, combat diabetes, other diseases 2Health News:Genomic surveillance of pandemic H1N1 2Health News:Bravo's 'Real Housewife' Comes to Boca Raton, Florida 2
... The Advanced® 2020 Multi-Sample Osmometer provides ... industrial, and research settings. These results ... freezing-point method, which determines total concentration. ... on-board data management, automated sample handling, ...
... Konica Minolta/Air-Shields® JM-103 Jaundice Meter® from Drger ... that will assist you in management of ... estimate of serum bilirubin levels reported in ... other clinical signs and laboratory measurements this ...
Anti-GBM IgG Assay...
Biotest ELPHA (=Enzyme Linked Probe Hybridization Assay) for class I and class II HLA typing shows convincing advantages for your lab routine....
Medicine Products: