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Preclinical and Phase 1 Data of VTX-2337 Presented at 2013 ASCO Annual Meeting Shows Early Activity in Ovarian Cancer
Date:6/3/2013

SEATTLE, June 3, 2013 /PRNewswire/ -- VentiRx Pharmaceuticals, Inc. in collaboration with the Gynecologic Oncology Group and the National Cancer Institute's Cancer Therapy Evaluation Program announced today that positive preclinical and clinical data of VTX-2337 in combination with Doxil® (pegylated liposomal doxorubicin) or paclitaxel in women with recurrent ovarian cancer were presented at the American Society of Clinical Oncology (ASCO) annual meeting. Results indicate that the combination of VTX-2337 and chemotherapy is well tolerated with no evidence of synergistic toxicities. Encouraging signs of efficacy provided the rationale for the ongoing randomized, placebo controlled Phase 2 study of VTX-2337 in combination with pegylated liposomal doxorubicin in patients with recurrent or persistent ovarian cancer (GOG-3003, NCT01666444)

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VTX-2337, a Toll-like Receptor 8 (TLR8) agonist, demonstrated a clear additive effect to Doxil in a humanized mouse model of ovarian cancer. Data demonstrated that this combination provides an enhanced effect in stimulating a variety of immune pathways associated with anti-tumor activity.

A Phase 1b trial conducted with the Gynecologic Oncology Group (GOG) in 13 patients with recurrent or persistent ovarian cancer demonstrated that the combination of VTX-2337 with Doxil is safe and well tolerated (GOG-9925, NCT01294293). The study reported no serious or unexpected drug-related adverse events and no evidence of synergistic toxicities. Eleven patients were evaluable for tumor response by RECIST 1.1. One patient achieved a complete response and 63 percent of patients had stable disease. A separate arm examining VTX-2337 with paclitaxel in 7 subjects showed similar tolerability with 43% stable disease.

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SOURCE VentiRx Pharmaceuticals, Inc.
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