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Preclinical Study Presented at AACR Annual Meeting Shows Peregrine's Anti-PS Immunocytokines Can Generate Protective Immune Responses in a Highly Aggressive Breast Cancer Model
Date:4/15/2008

, researchers irradiated an aggressive and metastatic strain of breast cancer cells coated with an immunocytokine comprised of the bavituximab equivalent 2aG4 fused with IL-2, which stimulates the immune system by activating anti-tumor T-cells. Mice were administered four doses of these irradiated immunocytokine-coated cells before receiving an implant of live breast cancer cells. Eight of the 10 mice, or 80%, receiving prophylactic pre-treatment with irradiated breast cancer and immunocytokine cells did not develop any tumors and remained tumor-free through 270 days post-treatment. Among control animals receiving either 2aG4 alone or IL-2 fused to a non-specific antibody, only two of 10 mice, or 20%, remained tumor-free. All of the control animals receiving irradiated breast tumor cells alone developed lethal tumors.

Dr. Philip Thorpe, an author of the study who is an advisor to Peregrine and a professor of pharmacology at UT Southwestern noted, "This study provides further evidence that our anti-PS antibodies have the potential to reverse the immunosuppressive effects of PS on some tumor cells, in addition to their well-documented ability to selectively target and destroy tumor blood vessels. We look forward to further investigating the clinical utility of these unique anti-cancer properties in combination with other anti-cancer regimens."

Bavituximab is a monoclonal antibody that binds to a phospholipid called phosphatidylserine that is usually located inside normal cells, but which becomes exposed on the outside of the cells that line the blood vessels of tumors, creating a specific target for anti-cancer treatments. Bavituximab helps mobilize the body's immune system to destroy the blood vessels needed for tumor growth and spread. In a Phase Ib pilot trial in advanced cancer patients, bavituximab plus chemotherapy appeared to have a safety profile consistent with chemotherapy alone and showed positive signs of clinical activity, achieving objectiv
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SOURCE Peregrine Pharmaceuticals, Inc.
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