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Preclinical Study Presented at AACR Annual Meeting Shows Peregrine's Anti-PS Immunocytokines Can Generate Protective Immune Responses in a Highly Aggressive Breast Cancer Model
Date:4/15/2008

- 80% of Subjects Immunized with Anti-PS Immunocytokines and Irradiated Tumor Cells Achieved Long-Term Survival Compared to Just 20% of Controls -

- Data Highlights Broad Anti-Cancer Potential of Peregrine's Anti-PS

Vascular Targeting Antibodies -

SAN DIEGO and TUSTIN, Calif., April 15 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) reported that a preclinical study presented yesterday at the 2008 Annual Meeting of the American Association for Cancer Research (AACR) demonstrates the vaccine-like ability of immunocytokine proteins combining its anti-phosphatidylserine (anti-PS) antibodies and cytokines such as IL-2 to generate robust and protective immune responses in a highly aggressive cancer model. Dr. Xianming Huang, assistant professor of pharmacology, and colleagues at the University of Texas Southwestern Medical Center at Dallas presented their findings from a study in mice assessing the efficacy of a tumor vaccine approach that uses these anti-PS immunocytokines in combination with radiation to achieve immunity to a lethal form of breast cancer.

Dr. Huang commented, "A likely contributor to the lack of immunogenicity of tumors is the fact that phosphatidylserine (PS) expressed on the surface of some cancer cells acts to dampen the body's normal immune response. By coating cancer cells with our anti-PS immunocytokines and then irradiating them to up-regulate the expression of the PS target, we were able to block the immunosuppressive effect of the PS. This enabled the pre-treated animals to leverage the T-cell activating effects of the IL-2 in the immunocytokine to mount a robust and sustained immune response to this unusually aggressive cancer."

In the study
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SOURCE Peregrine Pharmaceuticals, Inc.
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