Navigation Links
Preclinical Studies in Pancreatic Cancer and Melanoma Demonstrated ADI-PEG 20 Works Synergistically With Inhibitors of Autophagy
Date:4/11/2011

SAN DIEGO, April 11, 2011 /PRNewswire/ -- Polaris Group (Polaris) announced today that data from preclinical studies of ADI-PEG 20, the Company's pegylated arginine deiminase therapeutic, is synergistic with hydroxychloroquine (ChQ) in a human pancreatic cancer cell line and with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human melanoma cell lines. Both ChQ and TRAIL are known inhibitors of autophagy. These results support the commencement of Phase 1/2 clinical studies in these cancer types to investigate the combination of ADI-PEG 20 with autophagy inhibitors.

"We are excited to learn that ADI-PEG 20 can potentially be used in combination with yet another class of chemotherapeutic agents," commented John Bomalaski, M.D., executive vice president, medical affairs of Polaris. "ADI-PEG 20 has already demonstrated apparent efficacy and remarkable safety in clinical trials as a single agent. We are now making plans to initiate clinical studies to test the efficacy and safety of ADI-PEG 20 when used in combination with antitumor agents and other compounds."  

A summary of the abstracts follows:

Chloroquine induces defective autophagic flux and enhances pancreatic cancer cell death induced by pegylated-arginine deiminase

Rouebeh Daylami et. al. (AACR Abstract # 3782)

A majority of human pancreatic adenocarcinomas are deficient in argininosuccinate synthase (ASS) and are therefore sensitive to arginine deprivation by ADI-PEG 20. ASS-deficient cell lines undergo cell death when deprived of arginine, but also undergo autophagy. It is hypothesized that autophagy is protective in the setting of arginine deprivation and that inhibition of autophagy by hydroxychloroquine (ChQ) would increase cell death. The human pancreatic cancer cell line MIA-PaCa2 was treated in vitro and in vivo with ADI-PEG 20 alone or in the presence of ChQ. In vitro treatment with ADI-PEG 20 induce
'/>"/>

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
2. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
3. Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission
4. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
5. NicOx and Ferrer Present Promising Clinical and Preclinical Results in Dermatology
6. Isis Reports Preclinical Data Supporting Liver Safety of ISIS 301012
7. Preclinical Data on Lead MEK Inhibitor, RDEA119, to be Presented at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
8. KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
9. Tezampanel, TorreyPines Therapeutics Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego
10. Telik Announces Presentation of Preclinical Data on Dual Inhibitors of Aurora Kinases and VEGFR2
11. CorNova Preclinical Results of Valecor Platinum(TM) Coronary Stent Studies Presented at TCT 2007 Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... julio de 2015 BGI anunció hoy que ... alto rendimiento en Hong Kong ... (CAP). La instalación de BGI en Hong Kong ... próxima generación que recibe la certificación CAP en ... en prácticas de laboratorio clínico. Junto con el exitoso ...
(Date:7/2/2015)... 2015  AbbVie (NYSE: ABBV ) will announce ... 2015, before the market opens. AbbVie will ... at 8 a.m. Central time (9 a.m. Eastern). It ... www.abbvieinvestor.com . An archived edition of the call ... About AbbVie AbbVie is a global, ...
(Date:7/2/2015)... Wash. , July 2, 2015   BioLife Solutions ... and marketer of proprietary clinical grade cell and tissue ... a related cloud hosted biologistics cold chain management app ... today announced that Seattle Business Magazine has included ... to work for in Washington state ...
Breaking Medicine Technology:BGI recibe la acreditación del College of American Pathologists (CAP) 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 3
(Date:7/3/2015)... (PRWEB) , ... July 03, 2015 , ... ... exclusively to healthcare providers, has been retained to lead a national chief ... of the top-ranked executive search firms in the healthcare industry, B. E. Smith ...
(Date:7/3/2015)... Louis, MO (PRWEB) , ... July 03, 2015 , ... ... responsive website to replace their existing Talcum Powder Cancer Lawsuit Center website. Just as ... talcum powder lawsuit news , offering timely lawsuit updates and ovarian cancer warning ...
(Date:7/3/2015)... ... ... " Selfie on a Stick ” was featured on NewsWatch as part of ... consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted the review ... Almost every smartphone has an incredibly powerful camera built into it. And when someone ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Celebrity Dresses is currently running ... to those of celebrities will have the opportunity to get 10% discount on orders ... that people do not have to use coupon codes or remember redemption codes. ...
(Date:7/2/2015)... ... ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest ... the Lone Star State. The premium frozen yogurt chain was listed as #22 on ... opened July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy 64, Suite ...
Breaking Medicine News(10 mins):Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2
... , WASHINGTON, Sept. 16 Speaker Nancy Pelosi issued ... Baucus, Chairman of the Senate Finance Committee: , , ... and requiring accountability for insurance companies are two of our central ... forward to studying the impact of the Senate Finance Committee Chairman,s ...
... color perception in monkeys , WEDNESDAY, Sept. 16 (HealthDay News) ... possibility of a world in which they see colors like ... form of gene therapy to eliminate red-green color blindness in ... the squeamish, and there,s no guarantee that it will work ...
... ... harvest 2009-2010. ,Complete version available at http://www.pinenutoil.org/pine-nut-oil/wholesale-prices.php , ... New York, New York (PRWEB) September 16, 2009 -- In ... harvest 2009 - 2010 . , , , , ,The attention was drawn to one ...
... LAUREL, Miss., Sept. 16 The Jackson, Miss.-based civil trial ... is announcing a take-nothing defense verdict in a ... two other defendants, including ConocoPhillips Company and Montello, Inc. , , ... the companies in 2006 based on claims that his health problems were ...
... , , Pre-Event Registration Required to ... 16 This Friday, September 18th at 9:50 am, ... the economic and moral implications of health care reform. The panel will ... and will feature Congressman Tom Price (R-GA), Congresswoman Michele Bachmann (R-MN), and ...
... , HEMET, Calif., Sept. 16 In ... Grandchildren Task Force recently hosted an interactive senior sensitivity training ... in the day,s workshop at the Hemet Workforce Development Center ... Department of Public Social Services and Moreno Valley Police Department. ...
Cached Medicine News:Health News:For the Color Blind, a Ray of Hope 2Health News:Pine Nut Oil.org Presents Best Price for Pine Nut Oil 2Health News:Pine Nut Oil.org Presents Best Price for Pine Nut Oil 3Health News:Pine Nut Oil.org Presents Best Price for Pine Nut Oil 4Health News:Pine Nut Oil.org Presents Best Price for Pine Nut Oil 5Health News:Forman Perry Watkins Krutz & Tardy Announces Take-Nothing Verdict in Mississippi Asbestos Exposure Trial 2Health News:Townhall Comes to Washington: FRC Action to Host Congressional Forum on Health Care 2Health News:Riverside County Community Agencies Participate in Senior Sensitivity Training Provided by SCAN Health Plan 2
The 500 plate capacity MG-500 has an airlock for ease of use and an additional 100 plate capacity. Refrigeration is also available for growth of psychrophilic organisms...
... theatre is ready for all current and future ... design allows a quick, problem-free conversion to meet ... connected securely and sturdily to MARS through a ... should ever be a problem in spite of ...
23" Top Slide with Full Table Functions for Every Procedure...
... Just take the words "mobile operating table" ... for all important functions of a general purpose ... word promises: For table operations, a cable connected ... switch are available. Plus, there is a control ...
Medicine Products: