Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical D...( Cell Therapeutics Inc. (CTI) announ...),Health

Cell Therapeutics, Inc. (CTI) announces data presented at AACR-NCI-EORTC

Symposium

SAN FRANCISCO, Oct. 26 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC) and Systems Medicine, LLC (SM), a wholly-owned subsidiary of CTI, announced new preclinical data from several of its drug candidates during the 19th annual AACR-NCI-EORTC Symposium.

"These studies show potential progress toward identifying specific tumor types with a higher likelihood of demonstrating response to anti-cancer compounds early in clinical development and are critical to our goal of a highly focused clinical development strategy," said Jack W. Singer, M.D., Chief Medical Officer of CTI.

A new class of thienopyrimidine Src inhibitors demonstrates potent growth suppression of imatinib resistant Ba/F3 cells harboring a wide range of BCR-ABL mutations, including the CML relevant T315I (Abstract #B238)

Spyro Mousses, Ph.D., Senior Investigator and Director, Cancer Drug Development Laboratory at the Translational Genomics Research Institute (TGen) presented preclinical data that showed two thienopyrimidine Src inhibitors work in imantinib-resistant tumors, including the most frequent mutation leading to relapse. The study showed the Src inhibitors retained potent and non-selective cytotoxicity (at sub-micromolar concentrations) in cell lines previously shown to be susceptible and resistant to imatinib, including the T315I mutant cell line. The data suggest that the thienopyrimidine Src inhibitors may represent a new class of drugs with in vitro activity against chronic myelogenous leukemia (CML) variants with BCR-ABL mutations, warranting their exploration as potential new treatments for patients with imatinib-resistant forms of cancer. Preliminary in vitro data suggest these compounds are selective for Src.

"Continued development of these compounds is warranted to more extensively evaluate their selectivit
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