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Preclinical Data Demonstrate Ability to Regenerate an Entire Bladder With Tengion Neo-Bladder Replacement(TM)
Date:5/19/2008

Preclinical Results Show Neo-Bladder Replacement Structurally Similar to Native Bladder by Six Months; Data Presented at May 18 Press Briefing and

Poster Session

ORLANDO, Fla. and EAST NORRITON, Pa., May 19 /PRNewswire/ -- Tengion, Inc., a clinical stage biotechnology company focused on the development of neo-organs and neo-vessels, presented preclinical efficacy data for its Tengion Neo-Bladder Replacement(TM) at the Annual Meeting of the American Urological Association (AUA) in Orlando, Florida on May 18, 2008. The data were presented by Tim Bertram, D.V.M., Ph.D., Senior Vice President, Science and Technology of Tengion, during both a poster session and a press briefing sponsored by the AUA.

"In this well-established preclinical model, the Neo-Bladder Replacement was able to achieve functional recovery and a regenerative response that emulated the native bladder," said Dr. Bertram. "These data join the existing body of information from the preclinical studies of our first product candidate, the Tengion Neo-Bladder Augment, and underscore the promise and potential of our Autologous Organ Regeneration Platform as a foundation for our pipeline of regenerative medicine products."

The preclinical study presented at AUA was a six-month, single-arm study to evaluate the application of Tengion's technology to regenerate an entire urinary bladder. Neo-Bladder Replacements were produced from autologous bladder cells seeded onto a biodegradable scaffold and were then surgically implanted into 23 large mammals.

In this study:

-- Tengion's Neo-Bladder Replacement was able to regenerate an entire

urinary bladder within six months after implantation

-- The regenerated bladder demonstrated near-baseline capacity and

cystography by six months after implantation

-- The regenerated bladder wall structure consisted of three layers:

urothelium, muscle, and serosa by
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SOURCE Tengion, Inc.
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