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Precise Low-Dose Drug Monitoring Essential for Long-Term Kidney Transplant Success
Date:7/30/2008

accurate and precise test to monitor patients on low-dose treatment regimens. "At low doses, even the slightest variation in blood-level readings could be devastating to transplant patients. The consequence for the laboratory is twofold: it must have accurate, precise testing for immunosuppressive drugs, and tacrolimus tests that are accurate to 4 ng/mL are no longer adequate," he explained.

Dr. Levine reported results of his studies evaluating the performance of the Abbott ARCHITECT assay for tacrolimus, the most widely used immunosuppressant drug. He said the usual dosing range for the medication is between 2 and 15 ng/mL, with lower doses preferred. "The challenge for the laboratory, therefore, is to assure with the utmost confidence to the physician that a tacrolimus blood level of 3 ng/mL is exactly right and not 5," Levine said.

In the trials, the Abbott ARCHITECT tacrolimus assay was accurate and precise at low levels and showed consistent results. "The functional sensitivity in our hands was 0.9 ng/mL, exceeding the package insert claim of 2 ng/mL. We are fully confident the ARCHITECT tacrolimus assay meets our requirement for low-level tacrolimus monitoring," Levine said.

"The ARCHITECT tacrolimus assay is the only automated transplant monitoring test that meets international standards for low-level monitoring," according to Dr. Hebbar.

The ARCHITECT tacrolimus assay is used for the quantitative determination of tacrolimus in human whole blood, as an aid in managing liver and kidney transplant patients receiving tacrolimus therapy.

About the ARCHITECT Family

With its extensive menu of diagnostic tests, user-friendly software and advanced sample management capabilities, the ARCHITECT family and the currently marketed flagship analyzer, ARCHITECT(R) ci8200(R), meet the needs of today's diagnostics laboratory by enhancing workflow and productivity. ARCHITECT instruments are designed with laboratory-focused features su
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SOURCE Abbott
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