Navigation Links
Precise Low-Dose Drug Monitoring Essential for Long-Term Kidney Transplant Success

Study Highlights Performance of Abbott's ARCHITECT Tacrolimus Assay, Only Automated Transplant Monitoring Test that Meets International Standards for

Low-Level Monitoring

WASHINGTON, July 30 /PRNewswire-FirstCall/ -- The ability of blood tests to precisely measure very low doses of anti-rejection drugs in kidney transplant patients may make a significant difference in assuring long-term viability and survival, according to research presented today at the American Association for Clinical Chemistry (AACC) annual meeting.

The current thinking in transplant medicine favors reducing doses of tacrolimus and other immune-suppressive drugs as much as possible after kidney-transplant procedures. "Even though we are succeeding in preventing organ rejection, we haven't made much progress to improve long-term survival," said Sudarshan Hebbar, M.D., senior medical director, Abbott Diagnostics. "Unfortunately, most kidney transplant patients will go back on dialysis in eight to ten years, in part because the anti-rejection drugs can be toxic to the kidneys."

Dr. Hebbar added that kidney-transplant patients have high incidence of heart attacks and other cardiovascular disorders from long-term effects of renal disease. Therefore, minimizing drug toxicity over time is considered one way to help improve long-term graft survival and preserve quality of life for transplant patients.

To minimize long-term toxicity of transplant medications, physicians frequently aim to taper down doses of immunosuppressive drugs to as low a level as possible without risking rejection. "Successful low-dose regimens of tacrolimus and other anti-rejection medications require highly precise, ultra-sensitive drug-monitoring assays," said Daniel Levine, Ph.D., director of the clinical laboratory, Iris and B. Gerald Cantor Clinical Research Laboratory at The Rogosin Institute in New York City.

Dr. Levine emphasized the importance of using an accurate and precise test to monitor patients on low-dose treatment regimens. "At low doses, even the slightest variation in blood-level readings could be devastating to transplant patients. The consequence for the laboratory is twofold: it must have accurate, precise testing for immunosuppressive drugs, and tacrolimus tests that are accurate to 4 ng/mL are no longer adequate," he explained.

Dr. Levine reported results of his studies evaluating the performance of the Abbott ARCHITECT assay for tacrolimus, the most widely used immunosuppressant drug. He said the usual dosing range for the medication is between 2 and 15 ng/mL, with lower doses preferred. "The challenge for the laboratory, therefore, is to assure with the utmost confidence to the physician that a tacrolimus blood level of 3 ng/mL is exactly right and not 5," Levine said.

In the trials, the Abbott ARCHITECT tacrolimus assay was accurate and precise at low levels and showed consistent results. "The functional sensitivity in our hands was 0.9 ng/mL, exceeding the package insert claim of 2 ng/mL. We are fully confident the ARCHITECT tacrolimus assay meets our requirement for low-level tacrolimus monitoring," Levine said.

"The ARCHITECT tacrolimus assay is the only automated transplant monitoring test that meets international standards for low-level monitoring," according to Dr. Hebbar.

The ARCHITECT tacrolimus assay is used for the quantitative determination of tacrolimus in human whole blood, as an aid in managing liver and kidney transplant patients receiving tacrolimus therapy.

About the ARCHITECT Family

With its extensive menu of diagnostic tests, user-friendly software and advanced sample management capabilities, the ARCHITECT family and the currently marketed flagship analyzer, ARCHITECT(R) ci8200(R), meet the needs of today's diagnostics laboratory by enhancing workflow and productivity. ARCHITECT instruments are designed with laboratory-focused features such as the capability to prioritize emergency tests, the ability to use common reagents among platforms and sample monitoring. These features not only minimize training, but also reduce inventory costs and sample contamination potential, leading to better results for laboratories, physicians and, ultimately, patients.

About Abbott's Diagnostics Businesses

Abbott is a global leader in in vitro diagnostics and offers a broad range of innovative instrument systems and tests for hospitals, reference labs, molecular labs, blood banks, physician offices and clinics. With more than 65,000 institutional customers in more than 100 countries, Abbott's diagnostic products offer customers automation, convenience, bedside testing, cost effectiveness and flexibility. Abbott has helped transform the practice of medical diagnosis from an art to a science through the company's commitment to improving patient care and lowering costs. Abbott's history is filled with examples of first-of-a-kind diagnostic products and significant technological and research advancements.

About Abbott

Abbott is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs more than 68,000 people and markets its products in more than 130 countries.

Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Lifesaving Benefits of Low-Dose Aspirin Therapy Maintained With Naproxen Sodium
2. Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study
3. Echo Therapeutics Announces Positive Results of a Clinical Study of its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
4. Echo Therapeutics Announces Publication of Positive Clinical Data for its Symphony Transdermal Continuous Glucose Monitoring System in Journal of Diabetes Science and Technology
5. Echo Therapeutics Initiates Clinical Study of Its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
6. eRT Announces the Availability of the Suicidality Monitoring System(TM) For Clinical Trials
7. University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients
8. Independent Studies Report on Possible Roles for Cylexs Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients
9. Echo Therapeutics Announces Positive Results with the Prelude(TM) SkinPrep System, the Next-Generation Skin Permeation Medium for its Symphony(TM) Transdermal Continuous Glucose Monitoring System
10. Medicare Announces Expanded Coverage for Warfarin Patients Monitoring Clotting Time at Home
11. Independent Data Safety Monitoring Board Recommends Continuation of Sangarts Pivotal Phase III Trials of Hemospan(R) Following Second Interim Review
Post Your Comments:
(Date:11/29/2015)... -- The GE Health Cloud 1 was unveiled today at ... North America (RSNA) meeting in Chicago ... cloud ecosystem and its applications will connect radiologists and clinicians ... teams – both inside and outside the hospital setting. ... "As the digital industrial leader, we are betting big on ...
(Date:11/27/2015)... Une nouvelle approche consistant ... contre le cancer avancé.    --> ... au traitement photodynamique au Bremachlorin contre le cancer ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    Clinical Cancer Research . ...
(Date:11/27/2015)... , Nov. 27, 2015  Lannett Company, ... it has completed the acquisition of Kremers Urban ... subsidiary of global biopharmaceuticals company UCB S.A. (Euronext: ... Lannett has acquired KU from UCB for ... certain adjustments, including a customary working capital adjustment, ...
Breaking Medicine Technology:
(Date:11/29/2015)... ... November 30, 2015 , ... Gift ... company, Sublime Beauty NATURALS®. All products are available on Amazon or its webstore. ... organic facial serums and USDA Certified Organic Sesame Oil for Oil Pulling," says ...
(Date:11/29/2015)... ... 2015 , ... NewsWatch featured X-wing as part of its monthly Tech Report, ... technology expert and special reporter for NewsWatch, conducted the review and shared with viewers ... the future because flying cars are about to become a reality. Where’s the idea ...
(Date:11/29/2015)... ... November 29, 2015 , ... ProStatic Analog Distortion from ... designed specially for Final Cut Pro X. FCPX users can now ... modification controls. Destoying and creating chaotic distortion is now quick and simple, putting ...
(Date:11/28/2015)... (PRWEB) , ... November 28, 2015 , ... Safe storage ... creativity of two inventors, one from Lakewood, New Jersey and the other from Bradley ... the patent-pending PROTECTOR to save the expense of having to replace NuvaRings more often ...
(Date:11/27/2015)... ... November 28, 2015 , ... There is only one major question facing all ... year? , This question has not been an easy question to answer. Especially when ... and the younger workforce don’t share the same discipline around working long hours. ...
Breaking Medicine News(10 mins):