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Pre and Post-Operative Use of Caldolor® (Ibuprofen) Injection Significantly Reduces Pain and Opioid Use in Newly Published Study
Date:8/30/2010

n to more effectively manage post-operative pain for their patients."

The new data supports a previous randomized, placebo controlled trial in surgical patients, which demonstrated that 800 mg of IV ibuprofen dosed every six hours produced a significant reduction in pain and morphine use in surgical patients. The study, entitled "A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Intravenous Ibuprofen 400 and 800 mg Every 6 Hours in the Management of Post-operative Pain," was published in Volume 31, Number 9 of the peer-reviewed journal Clinical Therapeutics in October 2009.

Introduced in 2009, Caldolor is the first new injectable product available in the United States in 20 years for IV pain treatment, and provides safe and effective relief from both pain and fever. The newly published study, entitled "A Multicenter, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients" appears in Volume 11 of Pain Medicine. The publication can be found online at http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2010.00896.x/pdf.

About Caldolor Caldolor is indicated for the management of mild to moderate pain and management of moderate to severe pain as an adjunct to opioid analgesics, and for the reduction of fever in adults. It is the first FDA approved intravenous therapy for fever. Caldolor is contraindicated in patients with known hypersensitivity to ibuprofen or other NSAIDs, patients with asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Caldolor is contraindicated for use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery. Caldolor should be used with caution in patients with prior history of ulcer disease or GI bleeding, in patients with fluid retent
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SOURCE Cumberland Pharmaceuticals Inc.
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