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Potential Mechanism of Action Identified for the Treatment of Major Depression With Trigeminal Nerve Stimulation (TNS) - The USB Port to the Brain™
Date:7/5/2011

her assess the safety and efficacy of eTNS™ as a potential adjunctive therapy for the treatment of depression.  The trial began in February with a target completion date in late 2011.

Depression Background

Over 18 million Americans suffer from major depression, which affects mood, sleep, memory, concentration and raises thoughts of suicide.  It is the current leading cause of disability for 15-44 year olds.  The World Health Organization projects that after heart disease, major depression will be the most significant cause for disability in the world by 2020.

Antidepressant drugs are the most common therapy for depression, however they can have major side effects, including obesity, sexual dysfunction, fatigue, drowsiness and nausea.  Furthermore, prescribing antidepressants typically entails a trial and error selection process with only 30% of patients reaching remission with their first antidepressant trial.  Many patients abandon treatment before effectiveness can be determined.

NeuroSigma is developing two embodiments of TNS: eTNS™ and sTNS™ (subcutaneous electrodes).  Once approved by regulatory agencies, patients who respond well to eTNS™ can opt to switch to the implantable sTNS™ system.  

CAUTION: Both eTNS™ and sTNS™ systems are investigational devices and at this time are limited by United States law for investigational use only.

About NeuroSigma, Inc.

NeuroSigma is a Los Angeles-based medical technology company established to in-license and develop early stage technologies with the potential to transform medical practice.  Currently we have a specific focus on neuromodulation.  NeuroSigma employs two therapy platforms: Trigeminal Nerve Stimulation (TNS) and Deep Brain Stimulation (DBS).  NeuroSigma has amassed significant intellectual property licensed on an exclusive basis from the University of
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SOURCE NeuroSigma, Inc.
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