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Potential Mechanism of Action Identified for the Treatment of Major Depression With Trigeminal Nerve Stimulation (TNS) - The USB Port to the Brain™
Date:7/5/2011

ebral blood flow were detected in the anterior cingulate and the dorsomedial frontal cortical regions, which are brain regions implicated in mood disturbances – most notably the anterior cingulate gyrus, inferior frontal gyrus, medial and middle frontal gyri and the parietotemporal cortex."  Cook added, "These findings of a potential mechanism of action support our original hypothesis that electrical stimulation of the trigeminal nerves, located in facial skin tissue, can provide a very safe and effective means to send signals to key structures deep in the brain, thus providing a high-bandwidth pathway to the brain without current penetrating directly through the skull."  These four subjects realized a 44% reduction in their HDRS depression severity score during the 8-week treatment period.

"We would like to congratulate Drs. Cook, Lara Schrader, Daniel Silverman, Christopher DeGiorgio, and the rest of the UCLA team for these impressive PET findings," said Leon Ekchian, Ph.D., President and CEO of NeuroSigma.  "These results have identified a potential mechanism of action of TNS, should facilitate discussions with potential strategic partners and the investment community and have provided us with clues as to which indications to add to our TNS pipeline.  In addition to depression, we have clinical trials underway for epilepsy and post-traumatic stress disorder (PTSD) and expect to initiate clinical trials for additional indications in the near future," added Ekchian.

"We wish to especially thank Dr. John Mazziotta, Chairman of the UCLA Department of Neurology and Director of the UCLA Brain Mapping Center, which is widely regarded as the singular facility for neuroimaging in the world, for his support in making this breakthrough possible," said Lodwrick M. Cook, Chairman of NeuroSigma.

UCLA investigators have commenced the twenty-subject, double-blind, Phase II clinical trial, with funding provided by NeuroSigma, to furt
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