Navigation Links
Potentia Pharmaceuticals Announces Positive Safety Data and Study Expansion in Phase I Trial for Lead Drug Candidate POT-4
Date:9/29/2008

First complement inhibitor to be tested in AMD patients

LOUISVILLE, Ky., Sept. 29 /PRNewswire/ -- Potentia Pharmaceuticals, a privately held biotechnology company developing medicines for the treatment of age-related macular degeneration (AMD) announced today that the Company's leading drug candidate, POT-4, has shown early positive safety results in its Phase I study. POT-4 is a complement inhibitor, which shuts down the complement activation cascade that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular endothelial growth factor (VEGF). Based on this mechanism of action, POT-4 holds the potential to be effective against both dry and wet AMD.

"POT-4 has generated encouraging safety and tolerability data in this Phase I study and holds significant promise as a novel agent for treating AMD; a debilitating condition for which there is no cure," said Cedric Francois, President and CEO of Potentia. "As a result of the favorable early data, it was decided to expand the trial to permit further dose escalation, with the goal of prolonging the pharmacological benefit from POT-4. Potentia looks forward to the presentation of the Phase I data at a future medical conference and, with additional information gained from the extension of the study, to the initiation of Phase II trials in the future."

About AMD

AMD is the leading cause of blindness in the elderly of the western world and affects more than 10 million patients in the United States alone. The current standard of care for AMD relies primarily on angiogenesis inhibitors, an approach geared towards the approximately 10-15% of AMD patients with complications resulting from ocular angiogenesis (growth of new blood vessels and bleeding in the back of the eye). No drug currently on the market has been approved for the treatment of the remaining patients, who suffer from the so-called "dry" form of the disease.

Abo
'/>"/>

SOURCE Potentia Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
2. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
3. Peregrine Reports Data Showing Bavituximabs Potential to Shrink Prostate Tumors
4. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
5. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
6. Intellect Neurosciences, Inc. and CHDI, Inc. Enter Into Compound Testing Agreement to Evaluate OXIGON(TM) as a Potential Treatment for Huntington Disease
7. Study Published in Endocrinology Reports Potential of Modigene Technology to Extend Duration of Protein Drugs
8. Potential Breakthrough Cancer Treatment Emerges from MIPS-Funded Clinical Trial Teaming CSA Medical Inc. and University of Maryland Researchers
9. Synvista Therapeutics Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications
10. Potential Early Warning System for Lung Cancer Identified
11. Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 Research and ... "Global and Chinese Medical X-ray Film Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 Global And Chinese Medical ... in-depth study on the current state of the Global ... Chinese situation. The report provides a basic overview ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... ALBANY, New York , July 11, 2014 /PRNewswire/ ... published by Transparency Market Research "Endoscopy Devices Market (Endoscopes, ... Analysis, Size, Share, Growth, Trends and Forecast, 2013-2019" the ... billion in 2012 and is expected to grow at ... reach an estimated value of USD 36.9 billion in ...
Breaking Medicine Technology:Global and Chinese Medical X-ray Film Industry Report 2014 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... 2011 /PRNewswire-iReach/ -- In the world of veterinary ... is a 1 in 9 chance of anesthetic complications and ... cats. It is with great pride that LEI Medical ... history; having never had a single, equipment-related animal death reported. ...
... Medical Inc., a leader in developing minimally invasive medical ... tissue from the gastrointestinal tract, announces today that they ... Covidien.  Covidien is a leading global provider of healthcare ... Covidien will acquire all of the ...
Cached Medicine Technology:LEI Medical Emerges as an Innovator and Leads the Way in Safety 2LEI Medical Emerges as an Innovator and Leads the Way in Safety 3BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
(Date:7/12/2014)... Dennis Thompson HealthDay Reporter ... way to guarantee that a surgical technique used to grind ... increase the risk of spreading cancer to other parts of ... advisory panel to the Food and Drug Administration also said ... power morcellation -- should sign a written consent stating that ...
(Date:7/12/2014)... July 12, 2014 Demand Response Management ... considerable benefits in reducing the imbalance between energy supply ... appliances have been rolled out (due to increasing pressure ... (AMI). This helps in controlling residential appliances and thermostats ... in the North American region, and with government mandates ...
(Date:7/12/2014)... 12, 2014 Tylenol lawsuits ( ... move forward in the federal multidistrict litigation underway ... Bernstein Liebhard LLP reports. According to a filing ... F. Stengel has ordered the deposition of a ... found that the witness’s testimony concerning the marketing ...
(Date:7/12/2014)... SATURDAY, July 12, 2014 (HealthDay News) -- Burn injuries increase ... and outdoor grills, say burn experts. Among those most vulnerable ... among the most vulnerable and often get burned by putting ... Gamelli, director of the burn unit at Loyola University ... release. "The old adage of ,When you play with ...
(Date:7/12/2014)... 2014 “After my mom’s stroke, she loss the ... and loss the use of his left side. Eating became a ... to help people like them enjoy eating again,” said an inventor, ... the PATRICIA CAROL HALL PLATE (P C H PLATE). , The ... ergonomic way to eat for individuals who suffer from stroke, experience ...
Breaking Medicine News(10 mins):Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:Burn Injuries More Common in Summer 2
... peer pressure to share sexual images via the new phenomenon ... has found. ,Sexting, is the practice of sending and ... study is one of the first academic investigations into ,sexting, ... presented to the 2011 Australasian Sexual Health Conference in Canberra. ...
... -- Unspoken clues -- like behavior and appearance -- ... Researchers from the University of Michigan found subtle, nonverbal ... view their relationship with their doctor, they also affect ... better understand how they make decisions and what underlying ...
... Picky eating is normal in children, but a pediatric feeding ... a child,s physical and mental development, an expert says. ... clinical director of the Pediatric Feeding Disorders Program at the ... reject certain foods but still has a nourishing diet. Children ...
... (Sept. 29, 2011) Six leaders in stem cell ... key presenters at the world,s largest interdisciplinary stem cell ... World Stem Cell Summit, co-sponsored by the Cedars-Sinai Regenerative ... stem cell and regenerative medicine community. The Summit ...
... 29 (HealthDay News) -- Working rotating shifts is not ... to new Canadian research that suggests modern shift patterns ... older, more extreme shift schedules. "Recent research has ... although the biological mechanism responsible for this observation is ...
... J. Stang, Ph.D., editor of the Journal of the ... Jacqueline K. Barton, Ph.D. and Rakesh Agrawal, Ph.D., are ... to receive the nation,s highest honors in science and innovation. ... is guided by a passion for innovation, fearlessness even as ...
Cached Medicine News:Health News:'Sexting' driven by peer pressure 2Health News:Doctors Consider Nonverbal Cues in Medical Decisions 2Health News:Does Your Picky Eater Have a 'Feeding Disorder'? 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 2Health News:Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit 3Health News:Modern Shift Work Patterns May Be Less Harmful to Health 2Health News:White House honors editor of American Chemical Society journal and 2 ACS members 2
The PC4200h is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
The PC4200i is the largest capacity platelet incubator available. It features a built-in agitator with a capacity of 396 random bags (132 apheresis)....
... Platelet incubators hold rotators ... Incubator temperature can be set ... from 15C to 40C (59F ... 0.5C from top to bottom. ...
ELISA for detection of Anti-Gliadin IgA....
Medicine Products: