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Post Hoc Analysis from RECOVER Study Examined Effects of Neupro® (Rotigotine Transdermal System) on Surrogate Markers of Mood and Anhedonia in Parkinson's Disease
Date:6/9/2011

BRUSSELS, June 9, 2011 /PRNewswire/ -- A post hoc analysis from the RECOVER study (Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine Transdermal System) suggested that patients with Parkinson's disease who used Neupro® (rotigotine transdermal system) may experience improvements in key markers of mood/cognition, such as taking interest in surroundings and getting pleasure out of life.

Additional data presented from a one year open label follow-up of RECOVER supported the continuing benefits of rotigotine transdermal system on motor, sleep and nocturnal symptoms.

These data were presented at the 15th International Congress of Parkinson's disease and Movement disorders in Toronto, Canada (June 5-9, 2011).

Effects of rotigotine transdermal system on mood and anhedonia

A post hoc analysis of the RECOVER study suggested that rotigotine transdermal system may be associated with improvements compared with placebo on 4 of the 7 individual items in the mood/cognition domain of the Parkinson's Disease Non-Motor Symptom Scale (PDNMSS). These were loss of interest in surroundings (p<0.0001), loss of interest in doing things (p<0.0001), appearance of sadness or depression (p=0.005) and difficulty experiencing pleasure (p=0.0235).

"While further study is needed to confirm, this post hoc exploratory analysis from a randomized double blind placebo controlled study suggested beneficial effects of rotigotine transdermal system on markers of mood and anhedonia in Parkinson's disease," commented Professor K. Ray Chaudhuri, King's College Hospital, London, UK.

Continued effects of rotigotine transdermal system on motor function, sleep and nocturnal symptoms

In this open-label extension study the beneficial effects of rotigotine transdermal system on early morning motor function and sleep disturbances that were seen in the RECOVER study were maintained for a further year of tr
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