Navigation Links
Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Total Knee Arthroplasty Presented at International College of Surgeons World Congress
Date:12/6/2008

Findings as reported in the poster include:

  • Statistically significant reduction in pain versus Bup/epi in patients receiving EXPAREL 450mg at the end of general anesthesia, 5.0 vs. 7.0 pain intensity (P<0.05).
  • Statistically significant reduction in pain at the time of first opioid use in both EXPAREL 300mg and 450mg patient groups versus active control, 6.4 vs. 7.8 pain intensity and 6.1 vs. 7.8 pain intensity respectively (P<0.05).
  • Pain intensity was also lower with EXPAREL than with Bup/epi during activity at all postoperative intervals evaluated.
  • EXPAREL 450mg also significantly decreased the use of opioid rescue medications throughout the entire evaluation period plus postoperative nausea and vomiting occurrence was 40% lower than in the active control group.
    • Approximately 8% of patients in the EXPAREL 450mg group avoided all opioid use versus zero percent (0%) of patients in the active control group.
  • No differences were found in the safety profile of EXPAREL compared with bupivacaine. There were no clinical signs of either cardiac or central nervous system adverse events.

The multi-center, double-blind, randomized Phase II study used a parallel-group, active-control format to evaluate the efficacy and safety of EXPAREL for prolonged postoperative analgesia. Either a single intraoperative administration of EXPAREL or active control was given via local infiltration to 103 adult patients undergoing TKA in 5 centers across the U.S. and Europe.

TKA is the leading orthopedic surgery in the U.S. with approximately 534,000 procedures performed annually according to the National Center for Health Statistics. It is expected that the number of total knee replacement procedures will increase as our population continues to age. <
'/>"/>

SOURCE Pacira Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Kiadis Pharma Announces Positive Clinical Results for ATIR(TM) in Mismatched Bone Marrow Transplantations
2. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
3. Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union
4. Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia
5. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
6. Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial
7. Raptor Pharmaceuticals Corp. Announces Positive Phase IIa Clinical Study Results for Convivia(TM) Program
8. VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease
9. Poniard Pharmaceuticals Announces Final Top-Line Results from Phase 1 Trial Demonstrating Positive Bioavailability with Oral Picoplatin
10. Cepheid Molecular Diagnostic Test for Positive Blood Culture Bottles Categorized Moderate Complexity by FDA
11. Bionovo Advances BZL101 to Phase 2 Clinical Trials After Positive Phase 1 Results for Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2009)... 17 Decision Resources, one of the ... and healthcare issues, finds that the cost of ... and side-effect profile, are cited most frequently by ... of Avastin for non-small-cell lung cancer treatment in ... ,, The new Special European Physician & Payer ...
(Date:12/17/2009)... Suneva Medical, a privately-held aesthetic medical ... a multi-million dollar line of credit facility with ... credit facility will be used to fund commercial ... dermal filler on the market today, as well ... ,, "Today Suneva Medical entered into a multi-million ...
(Date:12/17/2009)... -- Express Scripts, Inc. (Nasdaq: ESRX ... management companies in North America, announced today ... association of seizure risk among epilepsy patients ... The study found no evidence that switching ... generic substitution, was associated with increased emergency ...
Breaking Medicine Technology:Surveyed European Oncologists Cite Cost Most Frequently as the Factor Preventing Their Use of Avastin for Non-Small-Cell Lung Cancer 2Surveyed European Oncologists Cite Cost Most Frequently as the Factor Preventing Their Use of Avastin for Non-Small-Cell Lung Cancer 3Suneva Medical Signs Multi-Million Dollar Line of Credit Agreement with Western Technology Investment 2Suneva Medical Signs Multi-Million Dollar Line of Credit Agreement with Western Technology Investment 3Express Scripts Study Finds No Association Between Anti-Epileptic Drug Switches and Increased Seizure Activity 2Express Scripts Study Finds No Association Between Anti-Epileptic Drug Switches and Increased Seizure Activity 3Sigma Aldrich to Present at the Thomas Weisel Healthcare Conference on Thursday September 10 2009 13838 1Selective Insurance Group Announces Officer Appointments 56161 1Selective Insurance Group Announces Officer Appointments 56161 2Selective Insurance Group Announces Officer Appointments 56161 3Radiologic Associates of Fredericksburg Hires Four New Physicians 56159 1Radiologic Associates of Fredericksburg Hires Four New Physicians 56159 2
... Arlington Medical Resources (AMR), a,provider of premier market intelligence ... $10 million of CSL Behring,s Privigen was,sold in the ... the newest,brand of intravenous immune globulin (IVIG) and was ... product created from the blood plasma of thousands,of donors ...
... BEDFORD, Mass., Nov. 13 Hologic, Inc.,(Nasdaq: ... of premium,diagnostics, medical imaging systems and surgical products ... announced the results of the,Cervista HPV high-risk pivotal ... under review by the FDA in the U.S. ...
Other Medicine Technology:Over $10 Million of CSL Behring's Privigen Was Sold in the U.S. During the Third Quarter of 2008 2Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 2Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 3Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials 4
(Date:12/17/2009)... "Comprehensive Respect for Life" in Majority Leader,s Revisions ... ,, WASHINGTON, Dec. 17 Americans United ... a letter today to Senate Majority Leader Harry ... the Majority Leader,s revisions to a bill - ... urges Senator Reid to include "specific language that ...
(Date:12/17/2009)... , , THURSDAY, Dec. 17 (HealthDay News) -- In a ... of the fish oil fatty acids that are good ... fats and the molecules that help them form clots. ... response has some potentially negative effects in comparison to ... Lindsay E. Robinson, an associate professor of nutrition at ...
(Date:12/17/2009)... Force pediatric surgeon Dr. Chris Coppola scrubbed in to perform surgery ... the swollen right lobe of his brain. Now, having returned from ... to provide medical aid to children living in Kabul’s largest internally ... ... -- , , ,During his first night on call in ...
(Date:12/17/2009)... information using virtually any smart phone , ... ... Inc., the world’s most trusted source for medical information delivered ... clinical decision application on the Google Android operating system. Skyscape’s ... devices, making the ability for medical professionals to download the ...
(Date:12/17/2009)... NEW YORK, Dec. 17 ... research report is available in its ... A strategic assessment of the competitive ... of the highest priority management responsibilities, ... growth and profitability. Timely and factual ...
Breaking Medicine News(10 mins):Health News:Pro-Life Leader Sends Urgent Letter to Senator Reid 2Health News:Could Omega-3s Boost Blood Fat Levels? 2Health News:U.S. Pediatric Surgeon Heals War's Youngest Victims in Iraq, Donates Medical Aid to Displaced Children in Kabul, Afghanistan 2Health News:U.S. Pediatric Surgeon Heals War's Youngest Victims in Iraq, Donates Medical Aid to Displaced Children in Kabul, Afghanistan 3Health News:Skyscape Offers Medical Professionals Real Time Clinical Decision Application on Google Android 2Health News:Skyscape Offers Medical Professionals Real Time Clinical Decision Application on Google Android 3Health News:Skyscape Offers Medical Professionals Real Time Clinical Decision Application on Google Android 4Health News:Reportlinker Adds Top Ten World's Leading Life Science Intermediates Companies 2
... Contrary to prevailing assumptions, children are more vulnerable ... age of 6 than they are in early childhood, ... to be presented May 4 at the annual meeting ... we typically worry about protecting toddlers from lead exposure, ...
... surprisingly low-level knowledge of typical infant development and ... emotional growth, according research from the University of ... false parenting assumptions can not only impair parent-child ... stimulation, will be presented Sunday, May 4, at ...
... for acid reflux, urinary incontinence ,slow down, seniors, studies ... Two new studies show that anticholinergics, a commonly prescribed ... down" in their daily physical activities. , The two ... Medicine support findings released a few weeks ago that ...
... facing the possibility of hysterectomy may now choose ... to Yale professor Aydin Arici, M.D., who will ... the American College of Obstetricians and Gynecologists (ACOG) ... Louisiana. , Arici will chair the two-day ...
... trial , , FRIDAY, May 2 (HealthDay News) -- The ... low levels of carbohydrates and controlled protein intake, helps ... a new study finds. , The trial is the ... diet -- widely used since the 1920s -- is ...
... most often , , SATURDAY, May 3 (HealthDay News) ... or more cough and cold medications during a given ... While cough and cold medications for children are widely ... used had not been scientifically studied. This new finding, ...
Other Medicine News:Health News:Children more vulnerable to harmful effects of lead 2Health News:Nearly one-third of US parents don't know what to expect of infants 2Health News:Common Medications Could Cause Physical Impairment in the Elderly 2Health News:Treatment advances for fibroids, menopause 2Health News:Special Diet Can Ease Epileptic Seizures in Kids 2Health News:10% of U.S. Kids Using Cough Medicine Every Week 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: