Navigation Links
Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Total Knee Arthroplasty Presented at International College of Surgeons World Congress
Date:12/6/2008

Findings as reported in the poster include:

  • Statistically significant reduction in pain versus Bup/epi in patients receiving EXPAREL 450mg at the end of general anesthesia, 5.0 vs. 7.0 pain intensity (P<0.05).
  • Statistically significant reduction in pain at the time of first opioid use in both EXPAREL 300mg and 450mg patient groups versus active control, 6.4 vs. 7.8 pain intensity and 6.1 vs. 7.8 pain intensity respectively (P<0.05).
  • Pain intensity was also lower with EXPAREL than with Bup/epi during activity at all postoperative intervals evaluated.
  • EXPAREL 450mg also significantly decreased the use of opioid rescue medications throughout the entire evaluation period plus postoperative nausea and vomiting occurrence was 40% lower than in the active control group.
    • Approximately 8% of patients in the EXPAREL 450mg group avoided all opioid use versus zero percent (0%) of patients in the active control group.
  • No differences were found in the safety profile of EXPAREL compared with bupivacaine. There were no clinical signs of either cardiac or central nervous system adverse events.

The multi-center, double-blind, randomized Phase II study used a parallel-group, active-control format to evaluate the efficacy and safety of EXPAREL for prolonged postoperative analgesia. Either a single intraoperative administration of EXPAREL or active control was given via local infiltration to 103 adult patients undergoing TKA in 5 centers across the U.S. and Europe.

TKA is the leading orthopedic surgery in the U.S. with approximately 534,000 procedures performed annually according to the National Center for Health Statistics. It is expected that the number of total knee replacement procedures will increase as our population continues to age. <
'/>"/>

SOURCE Pacira Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Kiadis Pharma Announces Positive Clinical Results for ATIR(TM) in Mismatched Bone Marrow Transplantations
2. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
3. Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union
4. Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia
5. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
6. Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial
7. Raptor Pharmaceuticals Corp. Announces Positive Phase IIa Clinical Study Results for Convivia(TM) Program
8. VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease
9. Poniard Pharmaceuticals Announces Final Top-Line Results from Phase 1 Trial Demonstrating Positive Bioavailability with Oral Picoplatin
10. Cepheid Molecular Diagnostic Test for Positive Blood Culture Bottles Categorized Moderate Complexity by FDA
11. Bionovo Advances BZL101 to Phase 2 Clinical Trials After Positive Phase 1 Results for Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... NOTTINGHAM, England , Oct. 1, 2014 ... today announced that its subsidiary, Molecular Profiles Ltd., is ... at the annual CPhI/ICSE Worldwide event in ... companies with the rapid development of both standard and ... screening platform, which incorporates the company,s existing formulation and ...
(Date:10/1/2014)... ANTWERP, Belgium and NEW YORK , ... global Contract Research Organization (CRO) and service provider for the medical ... the opening of offices in New York City ... New York City is strategically centered in one of ... the East Coast", said Philippe Kassab , President at genae ...
(Date:10/1/2014)... Oct. 1, 2014 Trovagene, Inc., (NASDAQ: ... today that Eli Diamond , MD, Assistant ... (MSK), presented clinical data from an ongoing study ... platform for the determination of oncogene mutational status ... The results were presented to both treating physicians ...
Breaking Medicine Technology:Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 2Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 3genae Opens Offices in New York City 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4
...  Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), ... progress in the development of ThermoVax™, its proprietary ... additional characterization of the stability of prototype vaccines ... excess of three months. These studies are being ...
... Medical, Inc. (OTCBB: AEMD), today released the following ... (Photo: http://photos.prnewswire.com/prnh/20090325/LA88762LOGO-b ) The ... disease targets is to measure changes in patient viral ... is detectable in circulation.  Specific to Hepatitis C virus ...
Cached Medicine Technology:Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability 2Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability 3Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability 4Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability 5Aethlon Medical Note: An Unprecedented Data Point, The Single-Treatment Capture of Hepatitis C Virus (HCV) by the Aethlon Hemopurifier® 2Aethlon Medical Note: An Unprecedented Data Point, The Single-Treatment Capture of Hepatitis C Virus (HCV) by the Aethlon Hemopurifier® 3Aethlon Medical Note: An Unprecedented Data Point, The Single-Treatment Capture of Hepatitis C Virus (HCV) by the Aethlon Hemopurifier® 4
(Date:10/2/2014)... The Business Intelligence Group today announced ... Business program. The BIG Awards specialize in recognizing ... process scored by well-known and experienced leaders and ... this year epitomize what is going right with ... Business Intelligence Group. “The sheer amount of innovation ...
(Date:10/2/2014)... have pinpointed a molecule that may trigger potentially life-threatening ... say this finding could offer a target for new ... Most asthma attacks (80 percent to 90 percent) are ... the British researchers. Most of these are rhinoviruses, which ... The researchers found that a specific molecule called IL-25 ...
(Date:10/2/2014)... Amy Norton HealthDay Reporter ... who have trouble smelling the roses -- literally -- may face ... research suggests. In a study of over 3,000 older Americans, ... rose, orange and peppermint were more than three times as likely ... sharp sense of smell. In fact, anosmia -- the inability ...
(Date:10/1/2014)... protein beta-amyloid is strongly associated with Alzheimer,s disease; however, ... peptide is the causal agent of the onset and ... confirmation is that beta-amyloid is not harmful when found ... when it self-assembles to form the so-called amyloid fibrils ... beta-amyloid alone, but with multiple ones because each aggregate ...
(Date:10/1/2014)... Philadelphia, PA, October 1, 2014 Patients with ... treatment, have a greatly increased risk of depression. ... therapy for chronic hepatitis C virus infection causes ... Omega-3 fatty acids, more commonly known as fish ... including lowering the risk of heart disease and ...
Breaking Medicine News(10 mins):Health News:Innovation Dominant Theme among 2014 Big Awards for Business Winners and Finalists 2Health News:New Clues to How Colds Can Spur Asthma Attacks 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:Omega-3 fatty acids may prevent some forms of depression 2
... Online ... clip on teen self esteem as part of its ongoing campaign and mission to affect change ... ... to the number one issue affecting today’s teen girl – low self esteem. It is a ...
... ... Championships Played on SnapSports® Volleyball Surfaces for a second year in a row. ... Pheonix, AZ (PRWEB) ... this year,s Phoenix Volleyball Festival on SnapSports® BounceBack® volleyball surfaces. The tournament is one ...
... ... and Organic Meat Raised Locally, , ... Seattle, WA (PRWEB) July 2, 2010 -- Bill the Butcher Inc. ... said J’Amy Owens, chief executive officer., , ,Located at 3800 34th Ave West in ...
... Allogeneic (donor-derived) stem cell transplant (alloSCT) may be a ... (CLL), regardless of the patient,s underlying genetic abnormalities, according ... in Blood , the journal of the American ... were diagnosed in the United States in 2009 and ...
... the brains of humans and other mammals differed from the ... presumably better). This belief was based, in part, upon the ... the brain responsible for complex cognitive behaviors. A new ... Diego School of Medicine finds that a comparable region in ...
... ... newly expanded pain treatment center in in the Los Angeles area. , ... (PRWEB) July 2, 2010 -- API and the ... Arcadia, California 91007. The Los Angeles area pain management clinic supplements the existing Encino Surgical ...
Cached Medicine News:Health News:Bellaboo Releases One Girl At A Time Documentary 2Health News:Phoenix Volleyball Festival Championships Played on SnapSports Volleyball Surfaces 2Health News:In Time for July 4th Grilling, Bill the Butcher Opens 5th Butcher Shop 2Health News:Patients with treatment-resistant CLL respond positively to stem cell transplants 2Health News:Our brains are more like birds' than we thought 2Health News:Our brains are more like birds' than we thought 3Health News:Advanced Pain Institute Opens Expanded Los Angeles Area Pain Management Center 2
... VISUCAM non-mydriatic fundus camera ... simplicity of fundus imaging. ... to set the standard ... features a unique combination ...
... Afinion HbA1c test and the ... you reliable facts conveniently available ... them. Advising the patient can ... The HbA1c Test Cartridge contains ...
An aid for advancing a pacemaker lead through the subcutaneous tissue of the chest wall to the pacemaker pocket....
The ARK-730A initiates automatic measurement at the optimum measurement point. The ARK-730A maintains fogging throughout multiple measurements, saving total examination time....
Medicine Products: