Navigation Links
Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA)
Date:12/14/2008

alating study evaluated the efficacy, safety, and pharmacokinetics of EXPAREL compared to bupivacaine HCL in 76 adult male patients (age ranges 48 to 63) in 10 hospitals in the UK and Australia. Subjects were randomized into one of four cohorts and intraoperatively administered either 175mg, 225mg, 300mg or 325mg of EXPAREL or 100mg bupivacaine HCL around the surgical wound by infiltration immediately before closure.

-- There was a statistically significant reduction in pain intensity with activity across all EXPAREL doses during the first 8 to 24 hours after surgery compared to bupivacaine HCL (P<0.05). Each patient's pain intensity score after surgery ranged from 21 - 31 across all EXPAREL groups compared to 45 - 48 for bupivacaine as measured by the Visual Analogue Scale (VAS) at 8, 12 and 24 hours.

-- The research also showed a trend toward lower opioid use in all EXPAREL groups compared to active control.

-- More patients in the EXPAREL groups completely avoided opioids 71% to 83% across doses, versus 50% for the bupivacaine groups.

-- Pharmacokinetic findings showed that a single intraoperative infiltration of EXPAREL resulted in dose-proportional sustained (72 hours) plasma concentrations of bupivacaine (>100mg/mL).

Safety assessments reported in the poster found EXPAREL to be safe and well-tolerated. Wound healing was normal in all EXPAREL subjects with no significant differences between cohorts. Adverse events were generally mild to moderate with no significant differences between cohorts and no serious adverse events were attributed to the study drug.

Inguinal hernia repair is one of the most common operations in routine surgical practice. In the U.S., more than 600,000 procedures are performed annually with a majority performed on an out-patient basis, according to the National Center for Health Statistics.

The Potential of EXPAR
'/>"/>

SOURCE Pacira Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH
2. Positive Phase 1 Clinical Trial Results for Transdermal Lidocaine
3. Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin
4. Forest Laboratories, Inc. and Cypress Bioscience, Inc. Announce Positive Results of Phase III Study of Milnacipran for the Management of Fibromyalgia
5. Positive Phase II Study of Paciras EXPAREL(TM) (DepoBupivacaine) in Total Knee Arthroplasty Presented at International College of Surgeons World Congress
6. Kiadis Pharma Announces Positive Clinical Results for ATIR(TM) in Mismatched Bone Marrow Transplantations
7. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
8. Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union
9. Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia
10. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
11. Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... May 1, 2015   Intarcia Therapeutics, Inc. ... as Vice President, Human Resources, reporting directly to ... As a new key member of the senior leadership ... and Leadership Team to assure the Company advances its ... embeds its core values and its dynamic culture. Another ...
(Date:5/1/2015)... , May 1, 2015 Hitachi Chemical Diagnostics, ... States launch of the ExoComplete™ 96-Well Plate ... easy system for exosome collection to mRNA purification.  The ... Vesicles ("ISEV") Annual Meeting, April 23 – 26, 2015, ... are intended for research use only of molecular biology ...
(Date:5/1/2015)... , May 1, 2015 Following yesterday,s release of ... D, here are five things you need to know: ... market-based structure is unique among government programs. ... D is different than other parts of Medicare and other ... that submit bids to offer prescription drug benefits to enrollees. ...
Breaking Medicine Technology:Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4New Products for Exosome Isolation to mRNA Purification 25 Things to Know About the CMS Part D Data Release 25 Things to Know About the CMS Part D Data Release 3
(Date:5/2/2015)... “ ActOn ” was featured on NewsWatch ... at the latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... organizations to make a difference. , In this material world, ... that aren’t about money, which is why those things should ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on ... features the latest and coolest technology products available to ... for NewsWatch, conducted the review and shared with viewers ... Music is an important part of people’s lives – ... the royal treatment. Peachtree Audio does just that with ...
(Date:5/2/2015)... Chicago, IL (PRWEB) May 02, 2015 Kare ... to provide support for busy caregivers. Kare Visits offers ... hospitals, and assisted living facilities. According to the ... caregivers spend an average of 20 hours a week caring ... fraction of the cost to hire a nurse, a caregiver ...
(Date:5/2/2015)... 2015 ZoomCare, the Portland-based innovator of ... to offer its new healthcare insurance to individuals and ... Health Insurance System is the nation’s first health insurance ... performance. ZOOM+ Personal Health Insurance was ZoomCare’s first such ... are subject to review and regulation by the Oregon ...
Breaking Medicine News(10 mins):Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:ZoomCare Applies to be on Oregon Exchange 2
... Penn State researchers shows that diets focusing on foods that are ... people to control hunger. ,Foods that are high ... soup, lean meat, and low-fat dairy products are low in ... ,Eating a diet that is low in calorie density allows people ...
... to enter rehab for treatment for alcoholism. ... 'Bon Jovi' has revealed the news, albeit without naming the ... facility in Los Angeles. He asks that you respect he ... the representative as saying. ,The magazine also reported ...
... fever, a devastating pig disease that could also threaten ... Friday. ,"This is a dramatic development," said ... FAO, noting that the highly contagious viral disease "has ... ,Armenia, Azerbaidjan and Russia "should be on ...
... deadly H5N1 bird flu virus in Hong Kong, agricultural officials ... the bird, found dead last week in the rural New ... ,They warned of personal contact with wild birds and live ... found dead in Hong Kong this year with H5N1, which ...
... on foods that are low in calorie density can promote healthy ... ,Foods that are high in water and low in fat ... are low in calorie density and provide few calories per ... calorie density allows people to eat satisfying portions of food, and ...
... Exhausted, stressed out and thinner than she used to be, ... life this week, and she's not even 18 yet . ... hopefuls struggling through China's university placement exams, a pressure-packed, make-or-break ... or trap her down in the faceless masses. ...
Cached Medicine News:Health News:Eating Smartly- A Key to Lose Weight 2Health News:Low Calorie Diet can Promote Healthy Weight Loss and Help Control Hunger 2Health News:Make-or-break Exams Stress China Youth 2Health News:Make-or-break Exams Stress China Youth 3
Pediatric: Binocular Balance, Tumbling "E" Monocular Acuity, Binocular Acuity, Fixation Disparity, Stereopsis...
Multi-Acuity: Letter Acuity, Tumbling E,and Allen Tests....
... antigen (PSA) is a serine protease that ... epithelial cells of the,acini and ducts. Normal ... 0.1-2.6 ng/ml. Reports have suggested that elevated,level ... the must useful tumor,markers in diagnosis of ...
Designed specifically for use with children ages,3 and up The patient is asked to distinguish between a "Raised E" and a non stereo target....
Medicine Products: