Navigation Links
Positive Phase I/II Data of IDX899 Confirm Potent Antiviral Activity and Favorable Safety Profile in Treatment-Naive HIV-Infected Patients
Date:6/12/2008

CAMBRIDGE, Mass., June 12 /PRNewswire-FirstCall/ -- Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX), a biopharmaceutical company engaged in the discovery and development of drugs for the treatment of human viral and other infectious diseases, today reported phase I/II data for IDX899, a non-nucleoside reverse transcriptase inhibitor (NNRTI) being developed for the treatment of HIV-1. Patients receiving once-daily IDX899 achieved a mean plasma viral load reduction of approximately 1.8 log(10) after seven days of treatment in each of the 800 mg, 400 mg and 200 mg dosing cohorts. Patients receiving placebo had a 0.05 log10 viral load increase over the same treatment period. No treatment-related serious adverse events were reported for any of the patients receiving IDX899 and no patients discontinued the study. Also, there were no discernable patterns in adverse events between treatment groups and there were no laboratory abnormalities during the treatment period. These data demonstrate potent antiviral activity and a favorable safety profile at all tested doses.

"The profound inhibition of HIV-1 virus replication of IDX899 at doses of 400 and 200 mg daily confirm the potent antiviral activity previously reported at higher doses," said Dr. Robert Murphy, John P. Phair Professor of Infectious Diseases, Director, Global Health Research, Feinberg School of Medicine, Northwestern University. "These early clinical data are very encouraging, showing that IDX899 offers potent viral suppression combined with a promising safety profile."

Study Design

The phase I/II clinical trial was designed to evaluate the safety, tolerability, antiviral activity and pharmacokinetics of IDX899. Three cohorts of 800 mg/day, 400 mg/day and 200 mg/day
'/>"/>

SOURCE Idenix Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Arena Pharmaceuticals Presented Positive Phase 2a Clinical Trial Results of APD125 for the Treatment of Insomnia at 22nd Annual Meeting of the Associated Professional Sleep Societies
2. Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus
3. Targeted Genetics Announces Positive Phase 1/2 tgAAC94 Data Presented at Annual European Congress of Rheumatology
4. Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors
5. Celator(R) Pharmaceuticals Announces Positive Phase 2 Results for CPX-1 in Treatment of Colorectal Cancer
6. AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures
7. Kosans Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
8. Trubion Announces Presentation of Positive TRU-016 Data at ASCO
9. Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients at 44th ASCO Annual Meeting
10. IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
11. European Unions CHMP Issues Positive Opinion on Sugammadex
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... LOS ANGELES , July 11, 2014 /PRNewswire-iReach/ ... of e-liquid, a vegetable-glycol solution for use in ... one of the active ingredients in cannabis, cannabidiol ... in personal vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds ...
(Date:7/11/2014)... 2014 Patient engagement has become a ... are turning to an assortment of marketing activities ... of this evolving approach to patient engagement, marketers ... engage patients throughout their experiences with a disease ... mapping the patient journey and employing a consumer ...
(Date:7/11/2014)... , July 11, 2014 The ... are evolving across industry sectors to better identify ... better ways to engage with and understand consumers, ... themselves and make critical purchasing decisions. ... Best Practices, LLC, one area where organizations can ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
... Medical Tactile, Inc. and Valentus Medical Technologies, Inc. ... , Canada , has signed a partnership agreement with Medical Tactile, ... SureTouch™ , the non-invasive digital breast imaging technology, worldwide, with the ... , , ...
... July 13 Amira Pharmaceuticals, Inc. today announced that the ... Activating Protein (FLAP) Inhibitors," which includes coverage of Amira,s AM103 and ... , , ... , Amira and GlaxoSmithKline (GSK) entered into a worldwide exclusive agreement ...
Cached Medicine Technology:Partnership Brings Breast Image Documentation Technology to Women Around the World 2Amira Announces AM103 and AM803 Patent Grant in the United Kingdom 2
(Date:7/12/2014)... 12, 2014 Wright & Schulte LLC has ... , Inc., a subsidiary of Johnson & Johnson, on behalf ... pain after receiving a metal-on-metal DePuy Pinnacle hip replacement and ... the artificial hip implant. The DePuy hip lawsuit was filed ... of Texas (Case No. 3:14-cv-2427) where DePuy Pinnacle Hip ...
(Date:7/12/2014)... 2014 “Critical Care Therapeutics in ... Late-Stage Four-Factor PCCs and Recombinant Products to Drive ... care market in the US, UK, France, Germany, ... an estimation of market size for 2013, along ... care indications that are being treated using the ...
(Date:7/12/2014)... Doylestown Hospital recently conducted an interview with ... questions. Paddock tackles topics including main men's health ... longer than men, and testosterone replacement therapy, among others. ... featured on Doylestown Hospital’s website, Dr. Brad Paddock says, ... If you notice pain, bulging, or asymmetry in your ...
(Date:7/12/2014)... 12, 2014 As reported in this ... Standards and Technology), the June 25th, 2014 Supreme Court ruling ... world. It was also met with both cheers ... whether it was seen from an individual privacy perspective, or ... fact, there is now precedent which will require law enforcement ...
(Date:7/12/2014)... Salt Lake City, Utah (PRWEB) July 12, 2014 ... Five spotlighted two types of startups, with awards being ... UVEF’s new emphasis spotlighted Utah’s outstanding entrepreneur community with ... are proving a sustainable model with incoming revenue. , ... companies from across the state that are under 5 ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2
... to a multitude of complications if left untreated. A ... of using tea as a form of treatment for ... to prevent the incidence of cataracts, a significant health ... ,Researchers developed special rats with diabetes. This provided ...
... Apollo Hospitals Group has been shortlisted by Britain's National Health ... UK where it could provide diagnostic services.// ,Long waiting ... of its operations to cut the delay faced by its ... radiology, including CT scan, MRIs, X-rays, endoscopy, ultra-sound and so ...
... stress during early life can lead to an increased ... It therefore, highlights the need for a counseling for ... growth. ,Several studies have established a relationship ... an increased risk of developing attachment disorders. These children ...
... at Harvard University, who say that these proteins and ... key to oncogenesis,// the process of formation of cancer ... protein known to cause cancer, is activated and becomes ... the hypothesis that an important component of oncogenesis is ...
... published in the Journal of the National Cancer Institute ... the link between diabetes and the prevalence and associated ... Susanna C. Larsson, M.Sc., of the Karolinska Institute in ... meant that individuals were at a 30 percent risk ...
... a very common disease of the present times; it is ... by way of incorporating specific foods has been found to ... clues for future diabetes treatment, following a doctor's advice on ... course of action and researchers are constantly on the lookout ...
Cached Medicine News:Health News:Apollo Hospitals Short-listed to Provide Diagnostics in the UK 2Health News:Teenage Mental Problems Could Be The Result Of Stress During Early Life 2Health News:Diet Effective In Curing Diabetes 2
Hydrophobic PE filter without self-sealing additives, permits sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human ...
... Resistant Tips offer a safe alternative to ... designed for applications such as PCR(a), pipetting ... ART Tips are excellent for tissue culture, ... ART Tips prevent aerosol contaminants and liquids ...
... Filters are ideal for ... methods, or for any ... might occur. They are ... solutions, infectious materials, labelled ...
Inquire...
Medicine Products: