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Positive Phase 2b Results with Sarilumab in Rheumatoid Arthritis to be Presented as a Late-Breaking Poster at the 2011 American College of Rheumatology Annual Meeting
Date:10/27/2011

e primary objective of the dose ranging portion of the trial was to demonstrate that sarilumab in combination with MTX is effective in reducing the signs and symptoms of RA at 12 weeks.  The five doses tested were 100 milligrams (mg) and 150 mg every week and 100 mg, 150 mg, and 200 mg every other week.  

The primary objective of the Phase 3 portion of the trial, which is currently enrolling patients, is to demonstrate that sarilumab in combination with MTX is effective in reducing the signs and symptoms of RA at 24 weeks.  The Phase 3 portion of the MOBILITY trial is evaluating two active doses of sarilumab, 150 mg and 200 mg administered every other week, compared to placebo.  Further details about the MOBILITY trial are available at http://clinicaltrials.gov/ct2/results?term=SAR+153191+mobility.

About Rheumatoid arthritisRheumatoid arthritis (RA) is a chronic systemic autoimmune disease affecting approximately 0.5%–1% of the global adult population.  Abnormal immune response causes an inflamed, thickened synovium, the membrane that lines the joint.  As synovitis expands, the inflammatory process can damage the bone and cartilage of the joint and the surrounding tissues.  RA-related inflammation can involve the heart and the lung.  In 10% of patients with RA, the liver is affected.  Complications of RA include anemia and leucopenia.  At times, RA can be very painful and affect a person's ability to carry out everyday tasks.  Most people with RA experience periods when their symptoms worsen (flares or active disease), separated by periods in which the symptoms improve.  Studies suggest that blockade of IL-6 signaling, one of several key cytokines involved in the inflammatory processes related to RA, may reduce inflammation of the joints, prevent long-term damage, and relieve certain systemic effects of RA, s
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SOURCE Regeneron Pharmaceuticals, Inc.
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