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Positive Phase 2b Results with Sarilumab in Rheumatoid Arthritis to be Presented as a Late-Breaking Poster at the 2011 American College of Rheumatology Annual Meeting
Date:10/27/2011

TARRYTOWN, N.Y., Oct. 27, 2011 /PRNewswire/ -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today announced that detailed clinical data from the positive Phase 2b portion of the seamless Phase 2/3 MOBILITY trial of sarilumab (REGN88/SAR153191) in rheumatoid arthritis (RA) will be presented at a late-breaking poster session at the upcoming American College of Rheumatology (ACR) Annual Scientific Meeting, which will take place from November 5-9 in Chicago. Sarilumab is a novel, high-affinity, subcutaneously administered, fully-human antibody targeting the interleukin-6 receptor (IL-6R)

The poster will be presented on Tuesday, November 8 from 9 AM to 6 PM EST. The abstract, titled "Sarilumab for the Treatment of Moderate-to-Severe Rheumatoid Arthritis: Results of a Phase 2, Randomized, Double-Blind, Placebo-Controlled, International Study," is available on the ACR website at: http://acr.confex.com/acr/2011/webprogram/Paper24502.html.

About SarilumabSarilumab (REGN88/ SAR153191) is the first fully human monoclonal antibody directed against the alpha subunit of the IL-6 receptor complex (IL-6R Alpha).  Sarilumab is a high affinity, subcutaneously delivered, specific inhibitor of IL-6 signaling.  It blocks the binding of IL-6 to its receptor and interrupts the resultant cytokine-mediated inflammatory signaling cascade. Sarilumab was developed using Regeneron's VelocImmune® antibody technology.  

About the MOBILITY trialThe MOBILITY trial is a randomized, double-blind, placebo-controlled, multicenter, two-part, dose ranging Phase 2b and confirmatory Phase 3 study with an operationally seamless design, evaluating efficacy and safety of sarilumab in combination with methotrexate (MTX) in patients with active RA who are inadequate responders to MTX therapy.  

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SOURCE Regeneron Pharmaceuticals, Inc.
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