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Positive Mid-Term Results on CryoValve(R) SG Pulmonary Human Heart Valve Presented at Western Thoracic Meeting
Date:6/30/2008

not completely seal when the valve is closed, causing regurgitation, or the backward flow of blood into the heart chamber. The data also indicated that there was a statistically significant reduction in valvular insufficiency in patients who received the CryoValve SG as part of the Ross Procedure as compared to the conventionally processed valve (67 percent of patients with trivial or less valvular insufficiency at last follow-up for CryoValve SG versus 51 percent for CryoValve).

For all other measured mid-term clinical endpoints there was no statistical difference between the CryoValve SG and the CryoValve recipients, including actuarial freedom from SVD at five years in patients undergoing Ross procedures (79 percent for CryoValve SG versus 78 percent for CryoValve), and for all patient groups there was no statistical difference between recipient groups for actuarial freedom from valve related death or explant at five years (Ross patients: 97 percent for CryoValve SG versus 95 percent for CryoValve; RVOT patients: 93 percent for CryoValve SG versus 89 percent for CryoValve), actuarial freedom from endocarditis at five years (Ross patients: 100 percent for CryoValve SG versus 99 percent for CryoValve; RVOT patients: 98 percent for CryoValve SG versus 100 percent for CryoValve) or actuarial freedom from cardiac reoperation at five years (Ross patients: 95 percent for CryoValve SG versus 95 percent for CryoValve; RVOT patients: 93 percent for CryoValve SG versus 90 percent for CryoValve), and transvalvular gradients or pressure change across the valve at last follow-up (Average Peak Gradient in Ross patients: 19.0 millimeters of Mercury for CryoValve SG versus 21.8 millimeters of Mercury for CryoValve; RVOT patients: 22.9 millimeters of Mercury for CryoValve SG versus 22.2 millimeters of Mercury for CryoValve).

About CryoValve SG

CryoLife's proprietary SynerGraft technology is designed to remove allogeneic donor cells and cellular remnants from t
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