Positive Five-Year Safety Data for TAXUS(R) Stent Reported in Boston Scient...()and all death and Q-wave myocardial inf...),Health

Date:10/22/2007

), and all death and Q-wave myocardial infarction (10.9% vs. 12.0%, p=0.57) were numerically lower in the TAXUS Stent group compared to the BMS group. The five-year rates of cardiac death and Q-wave myocardial infarction were identical between the TAXUS Stent and the control BMS (5.3% vs. 5.3%, p=0.96). Using the broader ARC definition of definite/probable, the TAXUS IV trial reported no cases of stent thrombosis between years four and five for the TAXUS Stent and one incidence of stent thrombosis for the BMS control group (0.0% vs. 0.2%, p=0.50), with a cumulative rate of stent thrombosis rate through five years being identical -- 2.5% for the TAXUS Stent and 2.5% for BMS (p=0.94).

"With the recent reversal of the SCAAR study, positive results from the Ontario database and excellent five-year data reported for TAXUS II and now TAXUS IV, the TAXUS Stent System has firmly established an outstanding long- term safety and efficacy record as evidenced by clinical trial data now reporting out to five years," said Paul LaViolette, Chief Operating Officer of Boston Scientific. "Also noteworthy is that the slow-release paclitaxel- eluting TAXUS Stent continues to demonstrate its effectiveness in preventing restenosis, or additional procedures, out to five years across a wide variety of patients and lesions."

The TAXUS IV five-year results support the long-term effectiveness of the TAXUS Stent with marked target lesion revascularization (TLR) reduction across a broad cross section of patients and lesions. When compared to BMS, the TAXUS Stent reduced the five-year rates of TLR by 56% (9.1% vs. 20.5%, p<0.0001), target vessel revascularization (TVR) by 38% (16.9% vs. 27.4%, p<0.0001), and major adverse cardiac events (MACE) by 27% (24.0% vs. 32.8%, p=0.0001). The rate of patients living free of TLR events was 90.9% at five years for the TAXUS group compared to 79.5% for the BMS control group (p<0.0001). The rate of patients living free of TVR events was 83.1% at f
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SOURCE Boston Scientific Corporation Copyright©2007 PR Newswire. All rights reserved

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