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Positive Data for Nektar's New Mu-Opioid Analgesic Molecule to Treat Acute Pain Highlighted at Neuroscience 2011
Date:11/14/2011

nced polymer conjugate technology designed to slow drug entry into the CNS.  By dramatically slowing the rate of drug entry into the CNS, NKTR-192 is intended to maintain opioid-like efficacy without the abuse potential and other CNS side effects associated with rapid-acting opioids.  In preclinical testing, NKTR-192 demonstrated a rapid onset of analgesia and relatively short half-life, without exhibiting sedative or abuse potential at analgesic doses.  Nektar intends to file an IND for NKTR-192 in the first quarter of next year and expects to advance NKTR-192 into clinical trials in the first half 2012.

About Opioids and Pain ManagementOpioid drugs are widely prescribed in pain management and are highly effective for treatment of moderate-to-severe pain.  Each year, there are over 250 million prescriptions written for these opioid painkillers in the U.S. alone.(1)   However, the FDA has identified prescription opioid abuse as a significant public health issue.  The abuse of these drugs has led to extremely high societal costs estimated in the tens of billions of dollars annually in the U.S.(4)  Rapid-acting opioids enter the brain quickly, frequently causing a euphoric effect, or "high" which results in high potential for drug abuse, addiction and diversion.  In addition to their potential to be abused, opioids can also cause drowsiness, impacting a patient's ability to function normally.  The pharmaceutical industry has invested heavily in the development of new formulations of these drugs in order to combat the abuse and diversion of these painkillers.  However, these reformulations have been primarily focused on physical means of deterrence, and abusers have found ways to overcome these formulation barriers.  

About NektarNektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms. Nektar
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