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Positive Data for Nektar's New Mu-Opioid Analgesic Molecule to Treat Acute Pain Highlighted at Neuroscience 2011
Date:11/14/2011

e treatment of acute pain, such as post-operative pain and other painful conditions like muscle or bone injuries.  We look forward to advancing this compound into the clinic in the first half of 2012."

Data from multiple in vivo and in vitro preclinical studies were presented at Neuroscience 2011. NKTR-192 exhibits a relatively fast onset of analgesia, within 5-15 minutes, in multiple preclinical in vivo models of pain.  Analgesia with NKTR-192 is comparable to oxycodone.  In preclinical in vivo models of self-administration used to predict the abuse liability of compounds, NKTR-192 shows a marked reduction in self-administration of drug as compared to both oxycodone and cocaine.  Additionally, in a series of in situ brain perfusion studies, NKTR-192 exhibits a significantly reduced rate of entry into the CNS as compared to fentanyl, oxycodone and hydrocodone. The preclinical data presented also demonstrated that NKTR-192 is a mu-opioid agonist, binding to receptors in the CNS and in the periphery, believed to be the primary mechanism of pain relief for opioid therapies.

These data will be highlighted during today's Neuroscience 2011 press conference to be held at 1:30 pm eastern time in the Walter E. Washington Convention Center in the Press Room.  The poster presentation entitled Harrison et al. "Pharmacological characterization of an orally active opioid analgesic with rapid onset of activity and low abuse liability (NKTR-192: An Orally Active Opioid Analgesic with Rapid Onset of Activity and Low Abuse Liability)" can be found on Nektar's website at http://www.nektar.com/product_pipeline/cns_pain_nktr-192.html .

About NKTR-192NKTR-192 is Nektar Therapeutics' product candidate for the treatment of moderate to severe acute pain.  NKTR-192 is a novel mu-opioid analgesic created using Nektar's adva
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SOURCE Nektar Therapeutics
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