Portola Announces Data Presentations Relevant to Its Lead Phase II Antithrombotic Compounds at American Heart Association Scientific Ses...( SOUTH SAN FRANCISCO Calif. Nov. 6...),Health

SOUTH SAN FRANCISCO, Calif., Nov. 6 /PRNewswire/ -- Portola Pharmaceuticals, a biopharmaceutical company developing innovative drugs that provide significant advances in cardiovascular and inflammatory diseases, and cancer, today announced that data relevant to betrixaban, the company's novel oral Factor Xa inhibitor and PRT060128, its novel ADP receptor antagonist, will be presented at the American Heart Association (AHA) Scientific Sessions 2008. The conference will be held at the Ernest N. Morial Convention Center in New Orleans, LA during November 8-12, 2008.

"We have important data being presented at AHA that demonstrate the potential of our differentiated Phase II compounds that address major unmet needs in preventing and treating thrombosis," said Charles Homcy, M.D., president and chief executive officer of Portola. "In particular, data from Dr. Paul Gurbel show how our antiplatelet agent may be effective in a high percentage of patients who do not respond adequately to clopidogrel, the current standard of care. Additionally, data being presented will show that our two Phase II agents, PRT060128 and betrixaban, our oral once-daily FXa inhibitor, may work in combination to inhibit thrombosis without raising bleeding risk. Together these data highlight some of the unique properties of our lead antithrombotic compounds."

Following are the details on each poster presentation.

Monday, November 10

Poster Title: "Combination of Direct Acting FXa Inhibitor and P2Y12

Antagonist at Non-Effective Doses Provides Significant Inhibition of

Arterial Thrombosis"

Patrick Andre et al

Time: 9:00 a.m. - 5:00 p.m.

Hall A-B1, Poster Board B129

Wednesday, November 12

Poster Title: "Oral Dosing of PRT060128, a Novel Direct-acting,

Reversible P2Y12 Antagonist Overcomes High Platelet Reactivity in

Patients Non-responsive to Clopidogrel Therapy"

Paul A. Gurbel et al