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Poor Physician Understanding of Drug-Coated-Balloon Mechanics Affects Perceived Effectiveness and Limits Adoption in Peripheral Vascular Treatment
Date:9/11/2013

TORONTO, Sept. 11, 2013 /PRNewswire/ -- According to Millennium Research Group (MRG), the global authority on medical technology market intelligence, physicians who use drug-coated balloons (DCB), also known as drug-eluting balloons (DEB), to treat peripheral artery disease, particularly in the lower extremities, lack awareness of some aspects of DCB function, which limits perceived effectiveness and inhibits wider adoption of these devices.

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For example, predilation is considered to have an important influence on DCB procedure efficacy. If the vessel is not predilated, some of the drug will be lost upon delivery to the lesion site. MRG's survey, however, shows vascular surgeons predilate in fewer than half of the lesions they treat with DCB. Of the total number of physicians surveyed, 10 percent never predilate at all. This modest use of predilation may result in poorer clinical outcomes, and thus influence physician perception of the efficacy of DCB treatment.

Physician opinions differed significantly on how long it takes a drug to diffuse through an artery wall, and how long the drug would remain in the deeper cell layers of the vessel wall. Knowledge of the actual speed and duration was limited. Both of these also affect their perceptions of the efficacy of a given device.

"There is clearly room for more robust clinical evidence and improved physician education on the mechanism of action for DCB," said Product Manager Stephanie LaBelle. "Manufacturers who are able to establish more clear evidence regarding the speed of drug diffusion and the duration of the drug in the vessel wall would boost physician confidence in DCB efficacy and increase adoption."

The results come from a new MRG report, The Use of Drug-Coated Balloons in Peripheral V
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SOURCE Millennium Research Group
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