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Pooled-Analysis of 54 Clinical Studies Shows No Increased Risk of Heart Attack With Abacavir Therapy
Date:8/6/2008

healthcare professional will review your medical history in order to avoid the use of abacavir if you have experienced an allergic reaction to abacavir in the past.

In one study, more patients had a severe hypersensitivity reaction in the abacavir once-daily group than in the abacavir twice-daily group.

ZIAGEN does not cure HIV infection/AIDS or prevent passing HIV to others.

Important Safety Information

ZIAGEN(R) contains abacavir sulfate, which is also contained in EPZICOM (abacavir sulfate and lamivudine) and TRIZIVIR(R) (abacavir sulfate, lamivudine, and zidovudine). Patients taking ZIAGEN may have a serious allergic reaction (hypersensitivity reaction) that can cause death. Your risk of having this allergic reaction is much higher if you have a gene variation called HLA*B5701 than if you do not. Your doctor can determine with a blood test if you have this gene variation.

If you get a symptom from 2 or more of the following groups while taking ZIAGEN, stop taking ZIAGEN and call your doctor right away:
1. Fever

2. Rash

3. Nausea, vomiting, diarrhea, or abdominal (stomach area) pain

4. Generally ill feeling, extreme tiredness, or achiness

5. Shortness of breath, cough, or sore throat

Carefully read the Warning Card that your pharmacist gives you and carry it with you at all times.

If you stop ZIAGEN because of an allergic reaction, NEVER take ZIAGEN or any other abacavir-containing medicine (EPZICOM, TRIZIVIR) again. If you take ZIAGEN or any other abacavir-containing medicine again after you have had an allergic reaction, WITHIN HOURS you may get life-threatening symptoms that may include very low blood pressure or death.

If you stop ZIAGEN for any other reason, even for a few days, and you are not allergic to ZIAGEN, talk with your healthcare professional before taking it again. Taking ZIAGEN again can cause a serious or life-threatening reaction, even if you never had a
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SOURCE GlaxoSmithKline
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