Pooled-Analysis of 54 Clinical Studies Shows No Increased Risk of Heart Attack With Abacav...(tory biomarkers that may be associated w...),Health

Date:8/6/2008

tory biomarkers that may be associated with cardiac risk, hs-CRP and IL-6, were evaluated from the HEAT trial, a large, randomized, controlled study of Epzicom and Truvada. The levels of these important biomarkers decreased from baseline at both 48 and 96 weeks for both abacavir and tenofovir. Additionally, there were no significant differences between the active comparitors in the study.

NRTIs currently constitute the cornerstone of combination antiretroviral therapy with abacavir recognized as a key component and recommended in treatment guidelines globally. GSK could not replicate the findings of the D:A:D analysis. In totality, the available data from the observational cohort and from clinical trials are inconclusive. It is clear however, that HAART overwhelmingly provides substantial survival benefits to HIV patients. As with all medications, physicians and patients must weigh the risks of HIV disease against the overall benefits and risks of the antiretroviral medicines available. As a precaution, the underlying risk of coronary heart disorder should be considered when prescribing antiretroviral therapies, including abacavir, and action taken to minimize all modifiable risk factors (e.g., hypertension, hyperlipidemia, diabetes mellitus, and smoking).

About Abacavir

Abacavir sulfate is a nucleoside reverse transcriptase inhibitor with a proven safety and efficacy profile as part of an HIV treatment regimen. Abacavir is a key component in Ziagen(R), Trizivir(R) and Epzicom(R). The most significant treatment-limiting event known to occur with abacavir is a hypersensitivity reaction, which occurs in approximately eight percent of patients and emerges within the first six weeks of therapy.

Important Safety Information about ZIAGEN

ZIAGEN, in combination with other antiretroviral agents, is indicated for the treatment of HIV-1 infection in adults.

ZIAGEN is one of 3 medicines containing abacavir. Before starting ZIAGEN, your
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SOURCE GlaxoSmithKline Copyright©2008 PR Newswire. All rights reserved

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