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Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference
Date:11/27/2007

of metastatic HRPC in combination with full-dose docetaxel (Taxotere(R)) and prednisone. The Company continues to expect to fully enroll this trial by the end of 2007. The Company expects to present clinical data from the Phase 1 and Phase 2 HRPC trials at scientific meetings throughout 2008.

Phase 1 Oral Picoplatin Trial:

An oral formulation of picoplatin is being evaluated in an ongoing Phase 1 clinical trial in solid tumors. Poniard has completed the planned enrollment of the planned dose levels and has expanded the enrollment to include additional testing of various dose levels to provide additional data to support further development. This Phase 1 study compares the bioavailability, pharmacokinetics, pharmacodynamics and safety of picoplatin administered orally with picoplatin administered intravenously in patients with advanced solid tumor malignancies. The company plans to present data from the Phase 1 trial at scientific meetings in 2008.

Lazard Presentation and Webcast Information

Dr. McMahon will present at the Lazard Capital Markets Fourth Annual Healthcare Conference today at 9:30 a.m. Eastern Time at The New York Palace Hotel. A live audio webcast of the presentation will be available for 10 business days on the "Events" page of the "News & Events" section of the Company's website at http://www.poniard.com.

About Picoplatin

Picoplatin is a new generation platinum chemotherapy agent with the potential to become a platform product addressing multiple indications, combinations and formulations. Picoplatin has an improved safety profile compared to existing platinum-based chemotherapeutics and was designed to overcome platinum resistance. Picoplatin has been evaluated in more than 750 patients and has demonstrated activity in multiple indications with no evidence of significant kidney, nerve toxicity and hearing loss. The Company is evaluating picoplatin in four dif
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