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Poniard Pharmaceuticals' Oral Picoplatin Demonstrates Positive Bioavailability in Ongoing Phase 1 Trial
Date:4/13/2008

- Picoplatin Also Shown to Overcome Platinum Resistance in Preclinical

Study - - Data Presented at Annual Meeting of American Association for Cancer

Research -

SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, April 13 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD), a biopharmaceutical company focused on oncology, today announced that an analysis of data from its ongoing Phase 1 clinical trial of an oral formulation of picoplatin in patients with solid tumors showed that picoplatin can achieve oral bioavailability of up to 44 percent in doses tested to date. These data are consistent with findings from preclinical oral bioavailability studies of picoplatin. The Company also announced findings from a preclinical study demonstrating that picoplatin retains its activity in small cell lung cancer (SCLC) cell lines made resistant by treatment with cisplatin, carboplatin or oxaliplatin. Picoplatin, the Company's lead product candidate, is a new generation platinum chemotherapy agent with the potential to become a platform product addressing multiple indications, combinations and formulations. The data were presented today in a poster session during the Annual Meeting of the American Association for Cancer Research (AACR) in San Diego.

"The data from our ongoing clinical study supports further development of an oral formulation of picoplatin," said Robert De Jager, M.D., chief medical officer of Poniard. "This includes the possible use in combination with other oral cancer therapies and radiation which would provide a novel treatment paradigm for platinum-based cancer therapy."

Additional results from the Phase 1 study presented at the
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SOURCE Poniard Pharmaceuticals, Inc.
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