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Polaris Group to Highlight Clinical Development Plans for Phase 3-Ready Candidate, ADI-PEG 20, During Symposium in Taiwan
Date:5/12/2011

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Additionally, Li-Zong Chen, M.D., Ph.D., of the National Institute of Health, and Jien-Fong Lee, M.D., of Chimei Hospital in Taiwan, will present data about ASS1 deficiency in sarcoma and its potential use as an indicator for cancer prognosis and treatment.  John Bomalaski, M.D., executive vice president, medical affairs, of Polaris Group will present data demonstrating the effectiveness of ADI-PEG 20 as a treatment for leukemia, lymphoma and sarcoma.  

In addition, Hsing-Jien Kung, Ph.D., of UC Davis Cancer Center will present data about ADI-PEG 20, autophagy and apoptosis, and implications for prostate cancer treatment.

Individuals interested in attending the symposium should e-mail ivylin@tdwpharma.com to register for the event.

About ADI-PEG 20

ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.

Multiple cancers have been reported to have a high degree of arginine-dependency. Phase 2 clinical trials have yielded positive results in patients with hepatocellular carcinoma or metastatic melanoma, and Phase 2 trials for small cell lung cancer and mesothelioma are currently ongoing. Polaris also plans to initiate clinical studies in prostate cancer, pancreatic cancer, leukemia, lymphoma and sarcoma this year.

About Polaris Group

Polaris Group is a privately held multinational biopharmaceutical company that specializes in the research and development of
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SOURCE Polaris Group
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