Navigation Links
Polaris Group to Highlight Clinical Development Plans for Phase 3-Ready Candidate, ADI-PEG 20, During Symposium in Taiwan

SAN DIEGO, May 12, 2011 /PRNewswire/ -- Polaris Group (Polaris) today announced that the Company will highlight clinical development plans for its Phase 3-ready pegylated arginine deiminase, ADI-PEG 20, during a symposium held on Tuesday, May 24, at 1:30 p.m. China Standard Time in Taipei, Taiwan.

Details about Polaris' upcoming pivotal Phase 3 clinical trial of ADI-PEG 20 in hepatocellular carcinoma (HCC) will be presented by the principal investigator, Ghassan Abou-Alfa, M.D., of Memorial Sloan-Kettering Cancer Center in New York. This presentation will include plans for enrollment in the global trial with sites in the United States, Taiwan, China and parts of Europe. Additional presentations during the symposium will provide updates for ongoing Phase 2 studies in small cell lung cancer and mesothelioma, as well as an outline of future development plans for ADI-PEG 20.

"This symposium comes at an important time for Polaris as we prepare for a global Phase 3 trial of ADI-PEG 20 treating hepatocellular carcinoma patients for which our Special Protocol Assessment was recently approved by the FDA," said Bor-Wen Wu, Ph.D., president and chief executive officer of Polaris Group. "We are proud to have multiple distinguished physicians present at this event and discuss the next steps in advancing ADI-PEG 20 through clinical development."

Presentations will focus on various aspects of the plan to investigate the potential for ADI-PEG 20 in indications beyond HCC.  Wu will present a broad overview of future clinical development plans for the therapeutic candidate, while individual physicians will discuss specific studies.

Background about the ongoing Phase 2 clinical trials of ADI-PEG 20 in small cell lung cancer and mesothelioma will be presented by the lead investigator of the mesothelioma study, Peter Szlosarek, M.D., Ph.D., of the Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London.  

Additionally, Li-Zong Chen, M.D., Ph.D., of the National Institute of Health, and Jien-Fong Lee, M.D., of Chimei Hospital in Taiwan, will present data about ASS1 deficiency in sarcoma and its potential use as an indicator for cancer prognosis and treatment.  John Bomalaski, M.D., executive vice president, medical affairs, of Polaris Group will present data demonstrating the effectiveness of ADI-PEG 20 as a treatment for leukemia, lymphoma and sarcoma.  

In addition, Hsing-Jien Kung, Ph.D., of UC Davis Cancer Center will present data about ADI-PEG 20, autophagy and apoptosis, and implications for prostate cancer treatment.

Individuals interested in attending the symposium should e-mail to register for the event.

About ADI-PEG 20

ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.

Multiple cancers have been reported to have a high degree of arginine-dependency. Phase 2 clinical trials have yielded positive results in patients with hepatocellular carcinoma or metastatic melanoma, and Phase 2 trials for small cell lung cancer and mesothelioma are currently ongoing. Polaris also plans to initiate clinical studies in prostate cancer, pancreatic cancer, leukemia, lymphoma and sarcoma this year.

About Polaris Group

Polaris Group is a privately held multinational biopharmaceutical company that specializes in the research and development of protein drugs to treat cancer and other debilitating diseases. The company's lead therapeutic, ADI-PEG 20, is advancing into a pivotal Phase 3 trial for hepatocellular carcinoma. Polaris is also investigating ADI-PEG 20 as a treatment for other arginine-dependent cancers, such as melanoma, prostate cancer, leukemia, lymphoma, sarcoma and pancreatic cancer. In addition to the ADI-PEG 20 project, Polaris is researching and developing other biotherapeutic agents and has a small molecule drug program that utilizes a rational structure-based approach to design novel compounds that inhibit the biological function of cancer-related protein targets.

For additional information please visit

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
2. Polaris Group Appoints Robert E. Hoffman as Chief Financial Officer
3. Simcere Pharmaceutical Group Filed 2010 Annual Report on Form 20-F
4. NxStage® Supports Initiative by Patient Advocacy Groups to Educate Policymakers about the Benefits of Frequent Home Hemodialysis
5. Frantz Medical Group Announces the Promotion of Stephanie Harrington to Chief Operating Officer
6. Winner Medical Group Inc. to Host Second Quarter 2011 Earning Conference Call on Wednesday, May 11, 2011 at 08:30 a.m. EDT
7. Chronic Disease Research Group Study Shows Daily Home Hemodialysis Therapy with the NxStage® System One™ is Associated with Lower Risk of Mortality and Higher Survival Estimates Compared to Conventional Thrice-Weekly Dialysis
8. Hanger Orthopedic Group Reports First Quarter Results
9. Global Pharm Holdings Group Obtains Business License for its Newly Established Joint-Venture in Jinan City
10. Simcere Pharmaceutical Group to Announce First Quarter 2011 Financial Results on Tuesday, May 10, 2011
11. Important Information for Atwater Carey First Aid Kit Consumers Regarding Triad Groups Povidone Iodine Prep Pads
Post Your Comments:
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):