Navigation Links
Polaris Group Doses First Patient in Phase 1 Clinical Trial of Lead Therapeutic Candidate ADI-PEG 20 in Pediatric Patients with Emphasis on Leukemia, Lymphoma and Sarcoma
Date:2/29/2012

in combination with docetaxel is ongoing. Thus ADI-PEG 20 has potential for therapeutic benefit in a number of cancers, and we look forward to continuing clinical development."

Additional information about the trial can be found online at
http://clinicaltrials.gov/ct2/show/NCT01528384?term=arginine+deiminase&rank=4.

About Pediatric Leukemia, Lymphoma and Sarcoma

Leukemia, lymphoma and sarcoma account for approximately 50% of childhood cancers. Leukemias are cancers of the blood, and account for approximately one-third of all cancers in the pediatric population. The major types are acute lymphocytic leukemia and acute myeloid leukemia. Lymphomas are cancers of the lymph nodes and related tissues. They account for approximately 10% of pediatric cancers. The major types are Hodgkin and non-Hodgkin lymphoma. Sarcomas and bone cancers attack either the soft tissues around the bone or the bone itself. They account for approximately 8 % of childhood cancers. The most common are rhabdomyosarcoma, osteosarcoma and Ewing sarcoma.

About ADI-PEG 20

ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine, which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.

Multiple cancers have been reported to have a high degree of arginine-dependency.

About Polaris Group

Polaris Group is a privately held multinational biopharmaceutical company that specializes in the rese
'/>"/>

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Polaris Group to Highlight Clinical Development Plans for Phase 3-Ready Candidate, ADI-PEG 20, During Symposium in Taiwan
2. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
3. Polaris Group Appoints Robert E. Hoffman as Chief Financial Officer
4. Current Study Offers Window into Automation & Outsourcing Practices Within Top Pharmaceutical Market Research Groups
5. Winner Medical Group Inc. to Host First Quarter 2012 Earnings Conference Call on Thursday, February 9, 2012 at 08:00 p.m. EST
6. Concord Medical Services Holdings Limited Engages Solebury Communications Group LLC to Establish a Strategic Investor Relations Program
7. Unity Management Group Subsidiary Announces First Contracts of 2012 with Purdue Pharma L.P. and Novartis
8. Utilizing Marketing Innovations to Engage with Customer Groups that are Key to the Pharmaceutical Industry
9. MiMedx Group, Inc. Board Announces Support for Chairman Parker H. "Pete" Petit
10. The Zacks Analyst Blog Highlights: UnitedHealth Group, Aetna, WellPoint, CIGNA and Wright Medical Group
11. MiMedx Group, Inc. to Present at the Noble Capital Markets 8th Annual Equity Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 28, 2014 Southern Research Institute today ... President and CEO of Southern Research Institute, has ... (CRS) for the 2014-2015 term.  The inauguration took ... 12 in Chicago with ... The Controlled Release Society is an international, ...
(Date:7/28/2014)... AUSTIN, Texas , July 28, 2014  MedSpring Urgent Care, ... new walk-in clinic at 517 S. Lamar Blvd., Austin, ... urgent care clinic is located on the southeast corner of ... doctor on-site from 9 a.m. - 9 p.m. daily, including weekends ... University of Texas, Central Austin , Anderson ...
(Date:7/28/2014)... , July 28, 2014 /PRNewswire/ ... in lifestyle healthcare and subsidiary of ... has acquired Physician Recommended Nutriceuticals (PRN) ® ... and related products for dry eye ... in a transaction worth up to ...
Breaking Medicine Technology:Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3MedSpring Urgent Care opens Barton Springs walk-in clinic in Austin, TX 2ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 2ALPHAEON Acquires PRN, A Leading Specialty Nutriceutical Company 3
... HILDEN, Germany, August 16, 2011   ... patients with non-small cell lung cancer (NSCLC) ... whether there is a subset of patients who are more likely ... Collaboration in lung cancer follows QIAGEN ...
... 2011 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: SSRX ... company focused on researching, developing, manufacturing and marketing biopharmaceutical ... second quarter and first half ended June 30, 2011. ... Total net revenues increased by 29.0% over ...
Cached Medicine Technology:QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 2QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 3QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 4QIAGEN and Pfizer Partner to Develop Companion Diagnostic for Novel Compound in Global Clinical Trials for Lung Cancer 53SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 23SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 33SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 43SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 53SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 63SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 73SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 83SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 93SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 103SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 113SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 123SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 133SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 143SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 153SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 163SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 173SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 183SBio Inc. Announces Unaudited Second Quarter and First Half 2011 Results 19
(Date:7/28/2014)... 28, 2014 A lush green lawn offers ... the summer. However, the summer heat, lack of rain, foot ... brown, weak and unhealthy. The Grounds Guys recommends these suggestions ... a lawn once a week and set the height on ... protects the grass roots from heat and allows roots to ...
(Date:7/28/2014)... 2014 An estimated 68,000 women and ... breast and prostate cancers – an aggressive form of ... to other parts of the body, such as the ... Drexel University College of Medicine have developed a ... metastatic progression by blocking tumor cells from β€œre-seeding.” Their ...
(Date:7/28/2014)... Ticket Down is reliable source for cheap ... at the Cotton Bowl. The 2014 Guinness International Champions Cup ... an eight team tourney. The tournament participants are top ... Liga, Serie A, English Premier League, and Superleague Greece. ... pitch include: Manchester United, Manchester City, Olympiacos, Inter Milan, ...
(Date:7/28/2014)... 28, 2014 Ticket Down is ... in Miami, FL at the Sun Life Stadium in ... football between Argentina and Brazil has is one that has ... more rivalries are forming on a consistent basis. The ... new height in the recent 2014 World Cup. To ...
(Date:7/28/2014)... Steven Reinberg HealthDay Reporter ... dementia and heart rhythm irregularities are more likely to get ... In fact, the study of more than 16,000 people ... more likely to get a pacemaker than those without the ... is why folks with dementia are so much more likely ...
Breaking Medicine News(10 mins):Health News:Nurturing Lawns in the Summer Heat: The Grounds Guys® Offers Tips on Caring for Lawns This Summer 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 2Health News:Drexel Scientists Develop Compound to Stop Spread of Metastatic Cancer Cells 3Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 2Health News:Brazil vs. Colombia Tickets in Miami: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Showdown 3Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 2Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 3
... ... will host two international events for Valentine,s weekend in Las Vegas: ... Rugby teams and the Power Pilates "Power Higher" Conference will host ... 16 national rugby teams, Pilates professionals and thousands of spectators from ...
... from University Hospital in Umea, Sweden, have identified several ... to rheumatoid arthritis (RA) disease onset. These findings ... risk of developing RA can be predicted and disease ... are published in the February issue of Arthritis ...
... Three new regional research centres that will study ... $6 million over five years from the Canadian Institutes ... of Health, made the announcement today at a national ... gender and health research. "Violence is a major ...
... , IRVINE, ... Cat College has commenced, but it,s not too late to register ... 2010 . , Cat College, sponsored by Eukanuba brand cat food, ... premier cat publication, and CatChannel.com, the leading online destination for cat ...
... who had brain or other central nervous system cancers, ... general public, according to an article published online January ... Institute . This study was undertaken because previous ... small, had contradictory findings, or were not population-based. ...
... study of Parkinson,s disease in the United States has found ... the Northeast and is twice as likely to strike whites ... on data from 36 million Medicare recipients, is both the ... disease in minorities and to show geographic clusters for the ...
Cached Medicine News:Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 2Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 3Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 4Health News:Rugby & Pilates Have a Date for Valentine's Weekend in Vegas 5Health News:Blood test can predict rheumatoid arthritis before symptoms arise 2Health News:Government of Canada invests in research to help prevent violence 2Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 2Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 3Health News:Eukanuba Partners With Cat Fancy(R) to Launch Cat College 4Health News:US Parkinson's rates highest in whites, Hispanics, and Midwest, Northeast 2
... has been selling replacement bulbs ... and we are extremely proud ... Check out our catalog of ... discount light bulbs specials. ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
Medicine Products: