Navigation Links
Polaris Group Doses First Patient in Phase 1 Clinical Trial of Lead Therapeutic Candidate ADI-PEG 20 in Pediatric Patients with Emphasis on Leukemia, Lymphoma and Sarcoma
Date:2/29/2012

in combination with docetaxel is ongoing. Thus ADI-PEG 20 has potential for therapeutic benefit in a number of cancers, and we look forward to continuing clinical development."

Additional information about the trial can be found online at
http://clinicaltrials.gov/ct2/show/NCT01528384?term=arginine+deiminase&rank=4.

About Pediatric Leukemia, Lymphoma and Sarcoma

Leukemia, lymphoma and sarcoma account for approximately 50% of childhood cancers. Leukemias are cancers of the blood, and account for approximately one-third of all cancers in the pediatric population. The major types are acute lymphocytic leukemia and acute myeloid leukemia. Lymphomas are cancers of the lymph nodes and related tissues. They account for approximately 10% of pediatric cancers. The major types are Hodgkin and non-Hodgkin lymphoma. Sarcomas and bone cancers attack either the soft tissues around the bone or the bone itself. They account for approximately 8 % of childhood cancers. The most common are rhabdomyosarcoma, osteosarcoma and Ewing sarcoma.

About ADI-PEG 20

ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine, which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.

Multiple cancers have been reported to have a high degree of arginine-dependency.

About Polaris Group

Polaris Group is a privately held multinational biopharmaceutical company that specializes in the rese
'/>"/>

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Polaris Group to Highlight Clinical Development Plans for Phase 3-Ready Candidate, ADI-PEG 20, During Symposium in Taiwan
2. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
3. Polaris Group Appoints Robert E. Hoffman as Chief Financial Officer
4. Current Study Offers Window into Automation & Outsourcing Practices Within Top Pharmaceutical Market Research Groups
5. Winner Medical Group Inc. to Host First Quarter 2012 Earnings Conference Call on Thursday, February 9, 2012 at 08:00 p.m. EST
6. Concord Medical Services Holdings Limited Engages Solebury Communications Group LLC to Establish a Strategic Investor Relations Program
7. Unity Management Group Subsidiary Announces First Contracts of 2012 with Purdue Pharma L.P. and Novartis
8. Utilizing Marketing Innovations to Engage with Customer Groups that are Key to the Pharmaceutical Industry
9. MiMedx Group, Inc. Board Announces Support for Chairman Parker H. "Pete" Petit
10. The Zacks Analyst Blog Highlights: UnitedHealth Group, Aetna, WellPoint, CIGNA and Wright Medical Group
11. MiMedx Group, Inc. to Present at the Noble Capital Markets 8th Annual Equity Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX: PVTTF) ... focus on Omega-3 therapies for cardiovascular disease (CVD) ... financial results for the fiscal year ended December ... in Canadian dollars unless otherwise stated. ... the right strategic partners and additional capitalization in ...
(Date:4/30/2015)... VIEW, Calif. , April 30, 2015  IRIDEX ... will release its first quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:4/30/2015)... NASHVILLE, Tenn. , April 30, 2015  Cumberland ... it will release first quarter 2015 financial results after ... conference call and live Internet webcast will be held ... Time to discuss the results. To participate ... or 253-237-1032 (for international callers).  A rebroadcast of the ...
Breaking Medicine Technology:Pivotal Therapeutics Announces 2014 Financial Results 2Pivotal Therapeutics Announces 2014 Financial Results 3Pivotal Therapeutics Announces 2014 Financial Results 4Pivotal Therapeutics Announces 2014 Financial Results 5Pivotal Therapeutics Announces 2014 Financial Results 6IRIDEX Announces First Quarter 2015 Conference Call and Release Date 2Cumberland Pharmaceuticals To Announce First Quarter 2015 Financial Results 2
... Pharmasset, Inc. (Nasdaq: VRUS ) has received ... (FDA) for PSI-938 for the treatment of chronic hepatitis C ... polymerase inhibitor of HCV. In March 2011, ... has potent antiviral activity and is generally safe and well ...
... 24, 2011 MedVantx, Inc., the company that created first ... today announced that Inc. Magazine has rated the company as ...  For the third year in a row, MedVantx has made ... Health Industry and thirteenth overall. The Inc. 500/5000 ...
Cached Medicine Technology:PSI-938 Receives Fast Track Designation from the FDA for the Treatment of Chronic Hepatitis C Infection 2PSI-938 Receives Fast Track Designation from the FDA for the Treatment of Chronic Hepatitis C Infection 3MedVantx Honored by Inc. 500/5000 Three Years in a Row 2
(Date:5/3/2015)... Boston, MA (PRWEB) May 03, 2015 ... received clearance from the FDA to produce and market ... This device can be used in outpatient settings and ... , The alternate posterior approach has been extensively researched ... a 510k approval to use this approach in conjunction ...
(Date:5/2/2015)... May 02, 2015 Vancouver fencing company, QS ... provide valuable advice to prospective clients related to their questions ... to install railings around their decks and patios. While that ... that pop up once the person rolls up their sleeve ... installing a railing in finding a gate that matches it. ...
(Date:5/2/2015)... Peachtree Audio ” was featured on NewsWatch as part ... and coolest technology products available to consumers. Scott Steinberg, ... the review and shared with viewers how this is ... important part of people’s lives – and as such, ... Peachtree Audio does just that with high-end audio equipment ...
(Date:5/2/2015)... May 02, 2015 With the success that ... is proud to welcome Neida Miranda and Alex Shields to ... Consulting has over 41 years of combined experience working with ... in the dental field for 8 years. She was ... Waco, Texas. Customer service, positive attitude and showing the importance ...
(Date:5/1/2015)... Freeport, ME (PRWEB) May 01, 2015 ... store in Freeport, Maine, reports on a new study ... pain, stiffness, joint swelling and improved physical function as ... people with severe osteoarthritis of the knee. , The ... “ Natural Insights for Well Being® ,” which Royal ...
Breaking Medicine News(10 mins):Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Veatch Dental Consulting Services Welcomes New Team Members 2Health News:New Study Finds Nutrients Ease Arthritis Pain, Retailer Reports 2
... this week by the U.S. Supreme Court will protect the rights of ... LLP . “The Supreme Court’s ruling this week is an important victory ... attorney Robert Kientz. , ... Austin, TX (Vocus) March 6, 2009 -- ...
... but some people don,t realize how precious it really is. 24k gold ... formulas on the market. , ... New York (PRWEB) March 6, 2009 -- While watching ... Gold. It,s common to hear that it has kept a rather high ...
... Diagnosing and treating obstructive sleep apnea may soon ... new research showing that a simplified program using ... positive airway pressure (CPAP) machines to titrate CPAP ... which relies on specialist physicians and sleep studies. ...
... Medical Association (NMA) congratulates the President and his staff ... in today,s forum. The NMA is committed to ... advocacy community, and other stakeholders, to ensure that the ... the President can sign before the Congress adjourns for ...
... of Hispanic health advocates is committed to achieving meaningful ... have work to do to cover the uninsured, improve ... someone has access it is to the type of ... L. Delgado, President and CEO of the National Alliance ...
... Stockholders to Vote the GOLD CardCINCINNATI, March 5 ... announces that RiskMetrics Group,s ISS Governance Services has ... Company,s current Board of Directors and reject all ... and election of replacement Directors, in the Joffe ...
Cached Medicine News:Health News:Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP 2Health News:Supreme Court Ruling is a Victory for Consumers Injured by Dangerous Drugs, Says Hissey Kientz, LLP 3Health News:Gold Not Only Valuable, It's a Healthy Skin Care Ingredient 2Health News:Less costly, more accessible and as effective: Simplified treatment for sleep apnea 2Health News:Less costly, more accessible and as effective: Simplified treatment for sleep apnea 3Health News:Alliance President and CEO Dr. Jane L. Delgado Joins President Obama at White House to Launch Health Reform Agenda 2Health News:Leading Proxy Advisory Firm RiskMetrics Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Proposals by Dissident Joffe Group 2Health News:Leading Proxy Advisory Firm RiskMetrics Recommends Shareholders Support LCA-Vision Board of Directors and Reject All Proposals by Dissident Joffe Group 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: