Navigation Links
Polaris Group Doses First Patient in Phase 1 Clinical Trial of Lead Therapeutic Candidate ADI-PEG 20 in Pediatric Patients with Emphasis on Leukemia, Lymphoma and Sarcoma
Date:2/29/2012

in combination with docetaxel is ongoing. Thus ADI-PEG 20 has potential for therapeutic benefit in a number of cancers, and we look forward to continuing clinical development."

Additional information about the trial can be found online at
http://clinicaltrials.gov/ct2/show/NCT01528384?term=arginine+deiminase&rank=4.

About Pediatric Leukemia, Lymphoma and Sarcoma

Leukemia, lymphoma and sarcoma account for approximately 50% of childhood cancers. Leukemias are cancers of the blood, and account for approximately one-third of all cancers in the pediatric population. The major types are acute lymphocytic leukemia and acute myeloid leukemia. Lymphomas are cancers of the lymph nodes and related tissues. They account for approximately 10% of pediatric cancers. The major types are Hodgkin and non-Hodgkin lymphoma. Sarcomas and bone cancers attack either the soft tissues around the bone or the bone itself. They account for approximately 8 % of childhood cancers. The most common are rhabdomyosarcoma, osteosarcoma and Ewing sarcoma.

About ADI-PEG 20

ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine, which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.

Multiple cancers have been reported to have a high degree of arginine-dependency.

About Polaris Group

Polaris Group is a privately held multinational biopharmaceutical company that specializes in the rese
'/>"/>

SOURCE Polaris Group
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Polaris Group to Highlight Clinical Development Plans for Phase 3-Ready Candidate, ADI-PEG 20, During Symposium in Taiwan
2. FDA Approves Special Protocol Assessment for Phase 3 Trial of Polaris Groups Cancer Therapeutic, ADI-PEG 20, in the Treatment of Hepatocellular Carcinoma
3. Polaris Group Appoints Robert E. Hoffman as Chief Financial Officer
4. Current Study Offers Window into Automation & Outsourcing Practices Within Top Pharmaceutical Market Research Groups
5. Winner Medical Group Inc. to Host First Quarter 2012 Earnings Conference Call on Thursday, February 9, 2012 at 08:00 p.m. EST
6. Concord Medical Services Holdings Limited Engages Solebury Communications Group LLC to Establish a Strategic Investor Relations Program
7. Unity Management Group Subsidiary Announces First Contracts of 2012 with Purdue Pharma L.P. and Novartis
8. Utilizing Marketing Innovations to Engage with Customer Groups that are Key to the Pharmaceutical Industry
9. MiMedx Group, Inc. Board Announces Support for Chairman Parker H. "Pete" Petit
10. The Zacks Analyst Blog Highlights: UnitedHealth Group, Aetna, WellPoint, CIGNA and Wright Medical Group
11. MiMedx Group, Inc. to Present at the Noble Capital Markets 8th Annual Equity Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 11, 2014  Major advances in radiation ... are being highlighted in a three-day Oncology Summit ... from 10-12 July, 2014.  Renowned national and international cancer experts ... practices and exchange knowledge on modern technologies making ... efficient. The Summit will address ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
(Date:7/10/2014)... July 10, 2014 Yesterday, former Congressman ... medical device manufacturing facility. Rep. Kennedy and ... monitors facilitate cutting-edge research in neurological disease and ... mental health advocate, Garen Staglin , created ... fostering fundamental changes that will radically accelerate the ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... Advanced BioHealing, Inc. (ABH), a leader in commercializing ... regenerative medicine, today announced results from a health economics ... that showed the addition of Dermagraft® to conventional care ... resulted in a significant therapeutic and cost benefit compared ...
... DIEGO, June 24, 2011 /PRNewswire/ -- ... Lilly and Company (NYSE: LLY ) today announced ... that showed the addition of BYETTA® (exenatide) injection to pre-existing ... heart failure, especially among patients receiving insulin. These findings will ...
Cached Medicine Technology:Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 2Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 3Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 4Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 5Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 2Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 3Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 4Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 5Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 6Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 7
(Date:7/11/2014)... WWTrek Human Outreach Project Team ... in Tanzania. Opened in 2012, the KKC is now home ... HOP Founder, Dean Cardinale, started the KKC to create a ... children he encountered while running treks on Tanzania's Mount Kilimanjaro. ... have all made astounding progress in school over the three ...
(Date:7/11/2014)... prescribed exercise as medicine, according to a QUT ... is essential to reducing the risk of death ... QUT,s Institute of Health and Biomedical Innovation, said ... and mental health, health professionals should be prescribing ... Anderson and QUT,s Dr Charlotte Seib co-authored a ...
(Date:7/11/2014)... Emily Johnson, owner of the Portland Fit Body Boot ... camp has held two charity workout events and is about ... from 7:15 - 8:30 at Col Summers City Park, SE 20th ... session raised $510 for Medical Teams International. Their second workout event ... Dream. On July 26th, Johnson and Portland Fit Body Boot ...
(Date:7/11/2014)... CO (PRWEB) July 11, 2014 H.E.A.R ... A new organization launches this week to provide comprehensive ... Reaching almost half a million Coloradoans with hearing ... to provide all encompassing information of the local and ... the deaf and hearing impaired. , H.E.A.R. Me Out ...
(Date:7/11/2014)... Leeds, England (PRWEB) July 11, 2014 Having ... later as a member of mental hospital staff, Roger Grainger ... among medical professionals in his new book, “You Never Get ... 4 people in the United Kingdom will experience some kind ... , “Society still needs to take a look at ...
Breaking Medicine News(10 mins):Health News:Human Outreach Project Sees Incredible Progress in the Kilimanjaro Kids Community 2Health News:Exercise is the best medicine: QUT study 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 3Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 2Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 3Health News:Psychiatric Hospital Patient and Registered Psychologist Explores Mental Health and Therapy in New Book "You Never Get Out" 2
... This release is available in French . ... researchers from the Institute for Research in Immunology and Cancer ... in the understanding of blood-producing (hematopoietic) stem cells. The study ... Guy Sauvageau, identifies factors that control the production of hematopoietic ...
... Singer/songwriter ... as the latest famous faces to lend their support to Hear the World, the ... of hearing and the consequences of hearing loss. , , ... (PRWEB) July 6, 2010 -- Singer/songwriter Corinne ...
... is often seen as the result of overpopulation, bad ... book, "The Atlas of World Hunger," reveals that the ... and in some ways more easily addressed than ... of Illinois geography professor Thomas Bassett and Illinois agricultural ...
... ... a larger office and more convenient location within the Boise medical community. Still ... close proximity to one of the major medical centers in Boise. This new ... collaboratively to help patients get and stay healthy. , ...
... cancer patients will together take part in the Hope on Wheels ... and apply colorful handprints to a white Hyundai Santa Fe. ... the country, is the symbol of Hyundai Hope on Wheels (TM). ... in the general population of young adults, 1 in 500 will ...
... A pilot study conducted in a small private high school ... of a delayed school start time. Judy Owens, MD, a ... delay in school start time of only 30 minutes was ... Her findings are published in the July issue of the ...
Cached Medicine News:Health News:Researchers identify factors behind blood-making stem cells 2Health News:More Big Names Line Up To Support Global Hearing Loss Awareness Initiative 2Health News:More Big Names Line Up To Support Global Hearing Loss Awareness Initiative 3Health News:Hunger atlas takes a new look at an old problem 2Health News:Hunger atlas takes a new look at an old problem 3Health News:Boise Acupuncture Clinic Grows into Larger Office 2Health News:New study confirms positive effects of delayed school start times 2Health News:New study confirms positive effects of delayed school start times 3
...
... within reach of virtually any facility...from a ... advanced cardiology hospital. This PC-based system includes ... for a Philips ergonomic stress cart and ... is designed to interface with the TrackMaster ...
... Cardioscan Viewer Phonocardiogram (PCG). The ZAC-Viewer ... you to record, condition, display and print ... The product acquires and displays the ... four sites, and allows user-selectable filtering of ...
... The biograph 6 offers ... improved disease diagnosis and treatment ... It delivers high-quality PET/CT whole ... 15 minutes. Our comprehensive suite ...
Medicine Products: