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Polaris Group Appoints Robert E. Hoffman as Chief Financial Officer
Date:3/15/2011

stages of clinical development."  

About ADI-PEG 20A key metabolic difference between some cancer cells and healthy cells is their dependence on the external supply of certain amino acids for survival and growth. ADI-PEG 20 is a pegylated form of arginine deiminase, an enzyme that depletes circulating arginine, which suppresses tumor cell growth while leaving healthy cells unharmed. ADI-PEG 20 has completed Phase 2 clinical trials in hepatocellular carcinoma (HCC) and in metastatic melanoma and is currently being investigated in Phase 2 trials in small cell lung cancer and in mesothelioma patients.

About Polaris GroupPolaris Group is a privately held, multinational biopharmaceutical company that specializes in the research and development of protein drugs to treat cancer and other debilitating diseases. The company's lead therapeutic, ADI-PEG 20, is advancing into a pivotal Phase 3 trial for hepatocellular carcinoma. Polaris is also investigating ADI-PEG 20 as a treatment for other arginine-dependent cancers, such as prostate cancer, leukemia, lymphoma, sarcoma and pancreatic cancer. In addition to the ADI-PEG 20 project, Polaris is researching and developing other biotherapeutic agents and has a small molecule drug program that utilizes rational structure-based approach to design novel compounds that inhibit the biological function of cancer-related protein targets.

For additional information please visit www.polarispharma.comMedia Contacts:Heidi Chokeir, Ph.D.Russo Partners(619) 528-2217(858) 380-6584heidi.chokeir@russopartnersllc.comJohn Bomalaski, M.D.Polaris Group(858) 452-6688, ext. 114jbomalaski@polarispharma.com
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