Navigation Links
Polaris Group Announces Treatment of First Patient in Phase 2 Study of ADI-PEG 20 in Acute Myeloid Leukemia
Date:11/6/2013

SAN DIEGO, Nov. 6, 2013 /PRNewswire/ -- Polaris Group announced today that the first patient has been dosed in its Phase 2 trial of ADI-PEG 20, arginine deiminase formulated with polyethylene glycol, for the treatment of Relapsed/Refractory Acute Myeloid Leukemia. Polaris Group is conducting clinical trials on ADI-PEG 20 for the treatment of several other indications, including hepatocellular carcinoma. The latter indication is already in a global Phase 3 study.

(Logo: http://photos.prnewswire.com/prnh/20131106/LA12039LOGO)

"Data from our collaborators show that acute myeloid leukemia cells require the amino acid arginine for growth, and that deprivation of arginine by ADI inhibits leukemia cell growth," said John Bomalaski, M.D., Executive Vice President of Medical Affairs at Polaris Group. "Treatment options for patients who have this form of leukemia are limited. We are pleased that the first patient in this trial has been treated with ADI-PEG 20 and we hope that ADI-PEG 20 will be of benefit to patients in this trial."

About ADI-PEG 20
ADI-PEG 20 is a biologic being developed by Polaris Group to treat cancers, especially those carrying a major metabolic defect that renders such cancer cells, unlike normal cells, unable to internally synthesize arginine. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, it is believed these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 is designed to systemically deplete the external supply of arginine, which causes arginine-dependent cancer cells to die while leaving the normal cells unharmed. Multiple cancers have been reported to have a high degree of arginine-dependency.

About Polaris Group
Polaris Group is a privately held biopharmaceutical company
'/>"/>

SOURCE Polaris Group
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
2. GSI Group Announces Financial Results for the Third Quarter 2013
3. CAO Group Launches New Pilot Diode Laser System
4. Simcere Pharmaceutical Group to Announce Third Quarter 2013 Financial Results on Thursday, November 14, 2013
5. Novartis Group calls on FDA to maintain the well-established naming policy for all biologics to help ensure patient safety
6. InspireMDs MGuard Stent Shows Lower Mortality Rate in STEMI Patients at Twelve Months Compared to Control Group
7. Securus Medical Group Raises $6.5M, Appoints New CEO
8. Pediatric Group Offers Consistent Vision Care Across Its Network with Spot Vision Screener
9. Long Island Plastic Surgical Group (LIPSG) Nominated in Four Categories for Best of Long Island 2014 Awards
10. Private Hospital Group in Spain Expands Radiotherapy Capabilities with Countrys First Elekta Versa HD System
11. Additional Results of Global Primary Biliary Cirrhosis Study Group Analysis to be Presented at AASLD Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 2015  In a sweeping analysis assessing the current ... Exchange researchers conclude that there remains considerable room ... all age groups, but especially for adolescents and young ... diabetes treatment, underscoring the need to address barriers to ... help type 1 patients achieve optimal metabolic control. ...
(Date:5/21/2015)... May 21, 2015 ... announced the addition of the "North ... Replacement, Digit Replacement, Elbow Replacement, Hip Replacement, ... 2019" report to their offering. ,     ... replacement was valued at $4,470.9 million in ...
(Date:5/21/2015)... 2015 Research and ... addition of the "Arthroscopy Devices Markets ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose of this ... world market for Arthroscopy Devices. The report ... the market for these products. , ,Product ...
Breaking Medicine Technology:Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
... STXS ) today announced that it will release ... December 31, 2010 on Monday, February 28, 2011 after the ... a conference call and webcast on Monday, February 28, 2011 ... and highlights of the fourth quarter and full year 2010. ...
... Calif., Feb. 9, 2011 On January 26, 2011, ... players were affected so severely by rhabdomyolysis that they ... it suggests an additional causal factor, such as a ... to lower cholesterol, are known in rare cases to ...
Cached Medicine Technology:Stereotaxis to Report Fourth Quarter and Full Year 2010 Financial Results and Conduct Conference Call on February 28, 2011 2Stereotaxis to Report Fourth Quarter and Full Year 2010 Financial Results and Conduct Conference Call on February 28, 2011 3Did ADHD Drugs Cause Muscle Damage in Iowa Football Players? 2
(Date:5/22/2015)... Pa (PRWEB) May 22, 2015 ... (AHN) today announced a new partnership to develop ... for the region. The initiative includes a new exhibit ... live demonstration theater, and a new traveling science ... the fall of 2015. , Designed to explore ...
(Date:5/22/2015)... VIEW, California (PRWEB) May 22, 2015 Coco ... has set a RecordSetter.com World Record at the 104th running ... Libre coconut water ice luge served 315 people in one ... Bay to Breakers race is so true to the heart ... we felt bringing an ice luge to the finish line ...
(Date:5/22/2015)... NY (PRWEB) May 22, 2015 Medivo, Inc., ... “Positivity Rates and Genotype Results in ‘Baby Boomers’ Screened ... from a Nationwide Lab Test Database” at Digestive Disease Week, ... Medivo’s Clinical Affairs and Analytics team members Carol Smyth, MB; ... and Andrea Parker, MSI, along with Nancy Reau, MD from ...
(Date:5/22/2015)... York, NY (PRWEB) May 22, 2015 Ticket ... Lightning vs. New York Rangers NHL Eastern Conference Finals Tickets ... is together unless specified otherwise in the ticket listing. ... York Rangers are at the top of the Eastern Conference. ... has had its share of ups and downs over the ...
(Date:5/22/2015)... May 22, 2015 A new program ... experts in the field of Physical Therapy. , ... takes the mystery out of physical therapy and discusses ... of motion for a variety of ailments and injuries. ... a personalized exercise plan that enhances daily activities such ...
Breaking Medicine News(10 mins):Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 4Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 3
... SEATTLE The worst global economic crisis in decades ... record amounts of money to health assistance for developing ... for Health Metrics and Evaluation (IHME) at the University ... health has grown 375% from $5.66 billion in 1990 ...
... obstructive sleep apnea (OSA), a sleep disorder associated with ... coronary arteries, according to a study presented today at ... America (RSNA). "Our study reveals that individuals with ... form of atherosclerosis that puts them at risk for ...
... say they have found an effective two-part treatment for microtears ... a steroid along with "dry-needling," in which repeated needle punctures ... the study were presented today at the annual meeting of ... the patient,s own blood where it is needed at the ...
... CHICAGO Using functional magnetic resonance imaging (fMRI), researchers ... a pain stimulus with and without acupuncture to determine ... of the study, which the researchers say suggest the ... meeting of the Radiological Society of North America (RSNA). ...
... CA, November 30, 2010 In the wake of multiple ... warning to four companies to remove their products from the ... of Preventive Medicine delineates the scope of the public health ... it. "Although several manufacturers of caffeinated beer have withdrawn ...
... (November 29, 2010) Whitehead Institute researchers have shown ... (miR-125b) can independently cause leukemia and accelerate the disease,s ... edition of the Proceedings of the National Academy of ... but in humans and mice, can upregulation of a ...
Cached Medicine News:Health News:Despite economic slump, donors give generously to global health, though at a slower rate 2Health News:Despite economic slump, donors give generously to global health, though at a slower rate 3Health News:People with sleep apnea at higher risk for aggressive heart disease 2Health News:Researchers use patient's own blood to treat hamstring injury 2Health News:Acupuncture changes brain's perception and processing of pain 2Health News:Caffeinated alcoholic beverages -- a growing public health problem 2Health News:Tiny RNA shown to cause multiple types of leukemia 2Health News:Tiny RNA shown to cause multiple types of leukemia 3
The Astigmatome makes precise and accurate cuts for astigmatism correction simply and safely. The procedure can be done in the office under topical anesthesia. Complete Set Includes Vacuum Speculum, ...
... of temporary sensing and pacing leads. Our ... temporary pacing leads and improved upon the ... and less traumatic to heart tissue. , ... to provide consistent temporary sensing and pacing ...
... indication for this technique is acquired ... Indications for tricuspid repair are based ... as diagnosed by angiography and dye ... In patients with an irreversible tricuspid ...
... Pro Medical Billing proudly offers distinct ... your area of expertise. ... diagnosis codes and medical records templates ... practice, ob/gyn, sports medicine, ophthalmology, allergy, ...
Medicine Products: