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Point-of-Sale Electronic Safety Check May Reduce Heart Attack Risk for Diabetic Patients
Date:4/12/2011

ST. PAUL, Minn., April 12, 2011 /PRNewswire/ -- According to a new pharmacy benefit study, a point-of-sale automated electronic safety edit, designed to require provider prior authorization (PA) for members who have a rosiglitazone claim with concurrent use of insulin or nitrate (CIN), potentially decreased members' risk for myocardial ischemia. The study will be presented at the Academy of Managed Care Pharmacy's 23rd Annual Meeting in Minneapolis, Minn. by Prime Therapeutics (Prime), a thought leader in pharmacy benefit management.

Rosiglitazone, also known under its brand name Avandia®, is an antidiabetic drug therapy (ADT) designed to help control blood sugar in patients with Type 2 diabetes mellitus. Studies suggest rosiglitazone and CIN can put patients at an increased risk for myocardial ischemia, a condition where the arteries in the heart become blocked, thus increasing a person's risk for heart attack.

To prevent use of rosiglitazone and CIN, one of Prime's Blue Cross and Blue Shield (BCBS) clients implemented an automated electronic safety edit that included 1.2 million members. The edit required a PA for rosiglitazone if a CIN drug supply already existed.

During the six-month study period (Jan-Jun 2009), 168 members had their rosiglitazone claim denied at the point-of-sale. Researchers conducted an observational cohort study to assess ADT utilization in the 168 members in which a rosiglitazone claim was denied. Researchers also assessed a control group of 222 members for whom the safety edit was inactive. Claims for both groups were periodically observed post-denial, or post-initial paid rosiglitazone claim among control group, to determine whether members continued with rosiglitazone, switched to a safer alternative or abandoned therapy altogether.

After 180 days, 78.6 percent of the 168 members with an initial safety edit claim denial were using a different ADT other than rosiglitazone, versus only 25.6 percent of
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SOURCE Prime Therapeutics
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