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Plavix(R) Indications Expanded in Japan to Include Patients with Acute Coronary Syndrome for Whom Percutaneous Coronary Intervention Is Being Planned
Date:10/21/2007

rmation and statements. These risks and uncertainties include those discussed or identified in the public filings with the SEC and the AMF made by sanofi-aventis, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in sanofi-aventis' annual report on Form 20-F for the year ended December 31, 2006. Other than as required by applicable law, sanofi-aventis does not undertake any obligation to update or revise any forward-looking information or statements.

References:

1 Guidelines for Management of Acute Coronary Syndrome without Persistent

ST segment Elevation (JCS 2002, Circulation Journal Vol.66, Suppl. IV.

2002, pp.1123-1163)

2 Guidelines for management of anticoagulant and antiplatelet therapy in

cardiovascular disease (JCS 2004, Circulation Journal Vol.68, Suppl. IV,

2004, pp.1153-1219)

3 The American College of Cardiology/The American Heart Association

4 ACC/AHA 2007 Guidelines for the Management of Patients With Unstable

Angina/Non-ST-Elevation Myocardial Infarction: Circulation 116: 803 -

877, 2007

5 The American College of Cardiology/The American Heart Association/The

Society of Cardiovascular Angiography and Interventions

6 ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary

Intervention: Circulation 113(7): e166 - e286, 2006

7 The European Society of Cardiology

8 Guidelines for the diagnosis and treatment of non-ST-segment elevation

acute coronary syndromes: Eur Heart J. 28(13): 1598-1660, 2007


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