Navigation Links
Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)
Date:2/11/2008

Results reported in The Journal of Immunology

SEATTLE, Feb. 11 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC) announced that pixantrone was shown to reduce the severity of clinical manifestation in the animal model of the autoimmune disease myasthenia gravis (MG). MG is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body due to autoantibodies acting against the Acethylcholine Receptor. The preclinical study was published in The Journal of Immunology (180:2696-2703, 2008) by Fulvio Baggi, M.D. and Renato Mantegazza, M.D., of the "Carlo Besta" Neurological Institute Foundation in Milan. The study compared pixantrone with the related drug, mitoxantrone, an agent currently approved to treat severe multiple sclerosis, also an autoimmune disease that attacks the central nervous system. In the current study, pixantrone was found to be more effective than mitoxantrone at improving both the laboratory and the clinical manifestations of the MG equivalent in rats. The authors concluded that "pixantrone [is] a promising immunosuppressant agent suitable for clinical investigation in myasthenia gravis, although additional experiments are needed to confirm its safety profile in prolonged treatments."

Current therapeutic treatment options for myasthenia gravis include corticosteroids and immunosuppressive drugs, both of which are effective in most patients. However, some patients do not respond to the standard treatments, and side effects may limit prolonged administration. Mitoxantrone has a broad immunosuppressive effect, but has cumulative cardiotoxicity and prolonged treatment can result in a decrease in left ventricular ejection fraction (LVEF -- the amount of blood the heart pumps out with each beat) or, rarely, congestive heart failure. Pixantrone's mechanism of action is similar to that of mitoxantrone -- both act as DNA intercalating agents and inhibit topoisomerase II, but preclinical data indicate that pixantrone is less toxic to the heart than mitoxantrone and prolonged administration may be possible.

"These results are intriguing, and, like the earlier data in animal models of multiple sclerosis, suggest that pixantrone may be of clinical utility in patients with severe myasthenia gravis or multiple sclerosis. We have been approached by European cooperative groups interested in performing clinical trials in both of these diseases," said Gabriella Pezzoni, Ph.D., Scientific Director of Cell Therapeutics Inc.'s European branch, and one of the investigators in the preclinical study on EAMG.

About the Preclinical Study

In an in vitro rodent model, pixantrone demonstrated a dose-dependent inhibition of T cell responses up to complete suppression of the proliferation in EAMG. EAMG was induced in subject animals using acetylcholine (T-cell) receptor, the autoantigen at the neuromuscular junction. The animals were randomly assigned to four treatment groups -- 1) preventive pixantrone (PIX)group, starting four days after immunization, 2) therapeutic PIX group, starting four weeks after immunization, 3) therapeutic mitoxantrone (MTX) group, starting four weeks after immunization, and 4) vehicle-treated animals as control groups. Doses of both pixantrone and mitoxantrone were equal to one-fourth of LD10 for single i.v. injection in animals. Although both pixantrone and mitoxantrone improved clinical symptoms, reduced weight loss and increased muscle acetylcholine receptor content compared with vehicle-treated rats, pixantrone appeared to be more effective at equitoxic doses.

About Pixantrone

Pixantrone is an investigational agent under development for the potential treatment of various hematological malignancies. It was developed to improve the activity and safety of the anthracycline family of anti-cancer agents. Anthracyclines have been shown to be very active clinically in a number of tumor types. However, they are usually associated with cumulative heart damage that prevents them from being used in a large proportion of patients. Pixantrone has been designed to reduce the potential for these severe cardiotoxicities, as well as to potentially increase activity and permit simplified administration compared to the currently marketed anthracyclines.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit http://www.cticseattle.com.

This press release includes forward-looking statements that involve a number of risks and uncertainties, the outcome of which could materially and/or adversely affect actual future results. Specifically, the risks and uncertainties that could affect the development of pixantrone include risks associated with preclinical and clinical developments in the biopharmaceutical industry in general and with pixantrone in particular including, without limitation, the potential failure of pixantrone to be tested in or have comparable results in human clinical trials of myasthenia gravis, determinations by regulatory, patent and administrative governmental authorities, competitive factors, technological developments, costs of developing, producing and selling pixantrone, and the risk factors listed or described from time to time in the Company's filings with the Securities and Exchange Commission including, without limitation, the Company's most recent filings on Forms 10-K, 8-K, and 10-Q. Except as may be required by law, CTI does not intend to update or alter its forward-looking statements whether as a result of new information, future events, or otherwise.

Media Contact:

Dan Eramian

T: 206.272.4343

C: 206.854.1200

Susan Callahan

T: 206.272.4472

F: 206.272.4434

E: media@ctiseattle.com

http://www.cticseattle.com/media.htm

Investors Contact:

Leah Grant

T: 206.282.7100

F: 206.272.4434

E: invest@ctiseattle.com

http://www.cticseattle.com/investors.htm

Medical Information Contact:

T: 800.715.0944

E: info@askarm.com


'/>"/>
SOURCE Cell Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting
2. Cell Therapeutics, Inc. (CTI) Launches Phase III Study for Pixantrone in Relapsed Indolent Non-Hodgkins Lymphoma (NHL)
3. Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells
4. JAK2 Inhibitor Shows Potent Activity in Cells From MPD Patients
5. Newly Approved HIV Drug Shows Great Promise
6. Kaiser Permanente - Group Health Study Shows Depression Worsens HIV Treatment
7. Research Shows Decas Sweetened Dried Cranberries Pack Twice the Proanthocyanidin Punch as Cranberry Juice Cocktail
8. New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol
9. CSL Behring Study in Animal Models Shows Feasibility of Developing a Half-Life Extended Recombinant FVIIa that Retains Biologic Activity
10. Study Shows That Low-Molecular Weight Heparin (LMWH) was Associated with Reduced Hospital Costs of Venous Thromboembolism (VTE) Treatment Compared with Unfractionated Heparin (UFH)
11. Celator(R) Pharmaceuticals Reports CPX-351 Shows Anti-Cancer Activity in Leukemia Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... FRANCISCO , February 28, 2017 The global  pulse ... a new report by Grand View Research, Inc. The pulse oximeters market is ... to the growing prevalence of target diseases such as chronic obstructive pulmonary disease ... Continue Reading ... Grand View Research ...
(Date:2/28/2017)... 2017 This report provides all the information ... interests and activities since 2010. Download the ... Partnering Deals and Alliance since 2010 report provides an ... the world,s leading life sciences companies. On ... inclusion of the most up to date deal and ...
(Date:2/28/2017)... , Feb 28, 2017 ... Research and Markets has ... report to their offering. The global orthobiologics ... The orthobiologics market is predominantly driven by the ... innovations in biomaterials, used in the production of orthobiologics are presumed ...
Breaking Medicine Technology:
(Date:2/28/2017)... Chicago, IL (PRWEB) , ... February 28, 2017 ... ... on Tuesday, March 7, 2017, from 4:30-5:30 p.m. at the 11th Annual RISE ... Stars, quality management, financial compliance, performance analytics, and engagement strategies. , The discussion ...
(Date:2/27/2017)... Hills, CA (PRWEB) , ... February 27, 2017 ... ... lose muscle mass and overall body strength, which often leads to a host ... the Journal of the American Geriatrics Society discovered that good overall ...
(Date:2/27/2017)... ... ... Robert E. Burke, MD, PhD, had a successful career as a pediatrician and ... have led him down a much different path. , In his book, “Beyond the ... Dr. Burke shares a personal account of the tribulations he encountered on his path ...
(Date:2/27/2017)... Fla. (PRWEB) , ... February 27, 2017 , ... Much ... but concern for women who become dependent on opioid painkillers has fallen short. From ... patients, compared to a 237% increase in fatal overdoses in male populations.(1) , The ...
(Date:2/27/2017)... Toledo, Ohio (PRWEB) , ... February 27, 2017 , ... Elisa Guajardo Carothers is not ... than Life” to studying to become a nun. Now, she writes about God, when she ... fiction, “You Know BC and AD, Here is BS! (Before Satan),” she offers a comedic ...
Breaking Medicine News(10 mins):