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Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment
Date:6/1/2009

Cycle No. of Patients Pixantrone Lifetime Treatment Cumulative Cumulative Dose Dose Median mg/m2 Median mg/m2 1 68 74 365.2 2 54 148 430.2 3 43 209 498.1 4 36 275 571.8 5 25 356 631.5 6 22 427 695.0

Lifetime doses of doxorubicin of over 550 mg/m2 are associated with a high incidence of CHF if the cumulative dose levels were solely with a standard anthracycline.

An additional new subgroup analysis was highlighted by the ASCO discussant, which demonstrated the clinical benefit associated with achieving a CR or CRu with pixantrone. On an intent-to-treat basis, patients achieving a CR/CRu on the pixantrone treatment arm (n=14) had a significant increase in the duration of remission compared with the four patients who achieved a CRu with standard chemotherapy (7 months vs. 3.5 months, p=0.03, HR=0.279; a hazard ratio of less than one indicates a decreased risk of disease progression and a p-value of less than 0.05 indicates statistical significance).

An analysis was also reported that evaluated the effect of prior rituximab therapy on response rates. In the 38 patients who received pixantrone following prior treatment with rituximab, 12 patients (32%) achieved a CR/CRu/PR of which six patients (16%) achieved a CR/CRu. In the comparator arm, the response rate was seven out of 39 patients (18%) with three CRu.

The discussant noted that overall respons
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SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
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