Navigation Links
Pixantrone Increases Progression-Free Survival by 81% Compared to Standard Chemotherapeutic Agents in Phase III Relapsed Aggressive non-Hodgkin's Lymphoma Trial
Date:1/27/2009

SEATTLE, Jan. 28 /PRNewswire-FirstCall/ -- Cell Therapeutics (CTI) (Nasdaq and MTA: CTIC) announced today preliminary progression-free survival (PFS) results from its pivotal phase III EXTEND (PIX301) trial of pixantrone that show patients with advanced, relapsed aggressive non-Hodgkin's lymphoma (NHL) treated with pixantrone experienced a statistically significant improvement in median progression-free survival, compared with other single-agent chemotherapeutic agents (4.7 months vs. 2.6 months, p < 0.01, pixantrone vs. standard chemotherapy) based on an intent to treat analysis. PFS was a prospectively defined secondary endpoint in the study.

"We always believed the effectiveness of pixantrone would translate into a meaningful difference for patients with relapsed aggressive NHL and these dramatic and significant differences in PFS in this tough to treat group of patients provides that evidence," stated James A. Bianco, M.D. Chief Executive Officer of CTI. "Pixantrone is the first agent in this patient population to demonstrate a significant and meaningful PFS advantage. We believe these data will support a priority review designation on our New Drug Application (NDA) once we share them with the Food and Drug Administration (FDA)."

The Company had previously announced that its pivotal phase III (PIX 301) EXTEND trial had achieved its primary endpoint with patients randomized to treatment with pixantrone achieving a significantly higher rate of confirmed (CR) and unconfirmed complete remissions (CRu) compared to patients treated with standard chemotherapy (14/70 (20.0%) for pixantrone arm compared to 4/70 (5.7%) for the standard chemotherapy arm, p = 0.02) with no patients in the standard chemotherapy arm achieving a confirmed complete remission. Additionally, pixantrone treatment also significantly increased the overall response rate (CR/CRu+PR) (26/70 (37.1%) for pixantrone arm compared to 10/70 (
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. (CTI) Launches Phase III Study for Pixantrone in Relapsed Indolent Non-Hodgkins Lymphoma (NHL)
2. Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkins Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting
3. Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)
4. Pixantrone to be Studied in Phase I/II Trial for Aggressive Multiple Sclerosis
5. Cell Therapeutics, Inc. (CTI) Announces Enrollment Complete in Phase III EXTEND (PIX301) Clinical Trial of Pixantrone in Patients With Second or Greater Relapse of Diffuse Large B Cell NHL
6. Cell Therapeutics Announces Study Data Set Cut-off for Phase III Pivotal Pixantrone (301) Trial
7. Cell Therapeutics Pixantrone Phase III (EXTEND) Pivotal Trial Successful in Achieving Primary Endpoint
8. Pixantrone Pre-NDA Communication from FDA Provides Cell Therapeutics Basis to Begin Rolling NDA Submission
9. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
10. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
11. Demand for VScan Dengue Fever Test Kits Increases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Pa. , Dec. 15, 2014  Inovio ... today it has been added to the NASDAQ ... Biotechnology Index will become effective upon market open ... Biotechnology Index is designed to track the performance ... classified as either biotechnology or pharmaceutical according to ...
(Date:12/15/2014)... 2014  Colorado and Washington State ... of cannabis. Oregon , Alaska ... prohibition during the November 2014 elections. Photo ... The benefits of legalizing cannabis are ... like the increased tax revenue for state and local governments, ...
(Date:12/15/2014)... MEADOWS, N.Y. , Dec. 15, 2014 ... the SPL (Structured Product Labeling) markup language standard, content ... the understanding and skills to work with the standard. ... a series of three webinars on the benefits and ... three one-hour webinars will be facilitated by Howard ...
Breaking Medicine Technology:Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 2Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 3Inovio Pharmaceuticals Added to NASDAQ Biotechnology Index 4CannaInsider.com Estimates 200,000 New Jobs in the Cannabis Industry by 2015 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3
... Mich., May 16, 2011 Perrigo Company (Nasdaq: ... approval from the U.S. Food and Drug Administration for its ... and cool mint), a generic version of Zantac 150®. We ... Zantac 150 (ranitidine) is indicated for the relief of heartburn ...
... Dune Medical Devices, Inc. today announced that ... accepted for filing the company,s Pre-Market Approval (PMA) ... mean that the PMA application was sufficiently complete ... believes MarginProbe represents a breakthrough technology that may ...
Cached Medicine Technology:Perrigo Announces FDA Final Approval for Ranitidine 150 - Generic Equivalent to Zantac 150® 2FDA Formally Accepts Dune Medical's MarginProbe™ System Pre-Market Approval (PMA) Application and Grants Expedited Review Status 2
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... , , HUDSON, Mass., Aug. 10 ... provider of high performance interconnect solutions for the most ... series circular connectors were selected by SynCardia Systems, Inc. ... to provide critical interconnect reliability for their Freedom(TM) driver, ...
... ... the past 12 months experienced a migraine attack whilst on holiday. Of those, one ... changes in sleep patterns and alcohol are all common migraine triggers and with 15% of the ... our holidays this year. , ...
... New Tool to be the Center of the One-of-a-Kind ... , BOSTON, Aug. 10 Boston University College of ... the unique and innovative nutrition program for the students, faculty and staff ... Program . Since partnering with BU Dining Services in 2004 to ...
... , , NEW YORK, Aug. ... , a leading global information and media company and the CLIO Awards, ... that access to the online entry system, currently open at www.CLIOHealthcare.com for first-ever ... entries, has been extended. For all work appearing between January 1, ...
... , , SEATTLE, ... in innovative fatigue management solutions for corporations, today announced that ... in the United States and one of the nation,s leading ... entered into an exclusive agreement with REM Medical to provide ...
... , SAN FRANCISCO, Aug. 10 ... Gastineau to senior vice president and chief executive of Blue ... (ISGBU). Gastineau joined Blue Shield in 2006 as vice ... and compliance areas in developing strategies to increase membership growth ...
Cached Medicine News:Health News:Hypertronics HyperGrip(R) and D Series Connectors Selected for SynCardia's Total Artificial Heart 2Health News:Latest Holiday Migraine Survey Results Published 2Health News:Latest Holiday Migraine Survey Results Published 3Health News:Boston University Launches Online Component of Sargent Choice 2Health News:Boston University Launches Online Component of Sargent Choice 3Health News:Nielsen Announces Entry Deadline Extension for the First-Ever CLIO Healthcare Awards 2Health News:REM Medical and U.S. HealthWorks Medical Group to Provide the First National Sleep Apnea Service Solution for the Transportation Industry 2Health News:Mark Gastineau Named Senior Vice President of Individual, Small Group, and Government Business Unit at Blue Shield of California 2
... Receiver is an optional component that ... outdoor and difficult environments. AeroScout Location ... measurement capabilities packaged in small, easy ... conditions. The Location Receiver receives transmissions ...
Integrate RFID and bar code technology with the new DR1000 Dual RFID/Bar Code Reader by Precision Dynamics Corporation (PDC). It provides an easy migration from bar codes to RFID tags for healthcare ...
... The SATO RFID printer reads, writes ... printing a visual image, text or barcode ... RFID printers are ideal for a range ... Access Control, Asset Tracking, Baggage Tagging, Retail ...
... only task-critical information to the operator ... Up to 14 additional computers can ... the facility using a dedicated local ... and administrators can all access the ...
Medicine Products: