Navigation Links
Pivotal Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint in Study of Patients With Advanced Pancreatic Neuroendocrine Tumors
Date:6/2/2010

EAST HANOVER, N.J., June 3 /PRNewswire/ -- Novartis Pharmaceuticals Corporation ("Novartis") announced today that a Phase III study of Afinitor® (everolimus) tablets plus best supportive care met its primary endpoint, showing the drug significantly extended progression-free survival, or time without tumor growth, in patients with advanced pancreatic neuroendocrine tumors (NET). The study, RADIANT-3 (RAD001 In Advanced Neuroendocrine Tumors), is part of the largest clinical trial program of its kind.

Everolimus is approved under the trade name Afinitor® (everolimus) tablets for the treatment of patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib.

Pancreatic NET can grow aggressively and at time of diagnosis nearly 60% of all patients have advanced disease, meaning the cancer has spread to other parts of the body and has become more difficult to treat(1),(2). The median survival rate for patients with advanced pancreatic NET is 17 months(2). Currently, surgery and chemotherapy are the only approved treatment options for patients with advanced pancreatic NET(1).

"Everolimus was developed to inhibit the mTOR protein, which is a critical target in treating various cancers, including NET. Results from RADIANT-3 demonstrate that everolimus has the potential to become an important treatment option for patients with advanced pancreatic NET, where there is a major unmet need," said Herve Hoppenot, President, Novartis Oncology. "These study results will serve as the basis of worldwide regulatory filings for everolimus and bring us one step closer to our goal of offering these patients a new therapy."

Full results
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
2. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
3. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
4. Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint
5. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
6. CryoCor Completes Enrollment of Pivotal Clinical Study for Atrial Fibrillation
7. Cadence Pharmaceuticals Completes Enrollment of Pivotal Phase III Trial for Intravenous Acetaminophen Ahead of Schedule
8. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
9. Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
10. Interim Response and Safety Analyses Support Continuation of Allos Therapeutics Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-Cell Lymphoma
11. Arbios Provides Clinical Strategy for SEPET(TM) Pivotal Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... , July 30, 2014 Stryker brand ambassadors ... week at the 3M Championship Champions Tour event near ... in Blaine . Stryker is the official joint ... Starting Friday, August 1 st through Sunday, August ... Mobility Zone; an on-site joint health destination located in the Pioneer ...
(Date:7/30/2014)... July 30, 2014 Cynosure, Inc. (NASDAQ: ... aesthetic treatments for non-invasive and minimally invasive applications, today announced ... Chief Operating Officer and Chief Financial Officer Timothy W. ... 2014.  Baker, 53, will continue to serve as CFO and ... , who remains Chairman and Chief Executive Officer. ...
(Date:7/30/2014)... Calif. , July 30, 2014 Silicon ... released a study today that examines the ... and medical device companies.  According to the annual report ... the biggest potential returns since SVB started tracking the ... of the IPO.  Built on solid healthcare M&A activity ...
Breaking Medicine Technology:Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 2Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 3Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 4Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 5Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3
... Armanino Consulting today announced that dpiX has ... and the integration of Microsoft Dynamics AX 2009 ... the production of digital X-ray sensors used in ... comprehensive business management solution for midsize and enterprise ...
... Foundation, in collaboration with Kessler Institute for Rehabilitation, announced ... exoskeleton investigational studies, which will commence October 17.  Made ... exoskeleton that enables wheelchair users to stand and walk. ... both its company name and product line on October ...
Cached Medicine Technology:Armanino Consulting Completes Integration of Microsoft Dynamics AX and Camstar MES for dpiX 2Armanino Consulting Completes Integration of Microsoft Dynamics AX and Camstar MES for dpiX 3Kessler Foundation Identifies Six Participants to Test Ekso 2Kessler Foundation Identifies Six Participants to Test Ekso 3Kessler Foundation Identifies Six Participants to Test Ekso 4
(Date:7/30/2014)... By Dennis Thompson ... -- Older people with depression are more likely to develop ... nature of the relationship between the two. Specifically, they ... the relationship works -- does depression help bring on dementia, ... new study published online July 30 in the journal ...
(Date:7/30/2014)... 2014 Ticket Down is a reputable ... Ann Arbor, MI on Saturday, August 2nd. Two of ... will be competing on American soil on Aug. 2 when Manchester ... Arbor, Mich. The home of the University of Michigan is also ... prestigious in all of American sports and has also hosted numerous ...
(Date:7/30/2014)... VA (PRWEB) July 30, 2014 ... be featured in an upcoming episode of Innovations ... via Discovery Channel. Dates and show times TBA. ... on Good Neighbor Community Services’ vision to redefine ... providing individualized and dynamic services. Through passion, innovation, ...
(Date:7/30/2014)... Alan Mozes HealthDay Reporter ... to help their preschooler shed excess pounds may want to ... whose parents joined them in a supervised behavioral modification program ... a traditional child-only program (an average difference of about four ... almost 15 pounds over two years, according to the study. ...
(Date:7/30/2014)... 2014 Volunteers from the Church of ... abuse this summer with massive distribution of Truth ... find these volunteers on Strøget, the famous Copenhagen walking ... its shopping and its ambiance, some quarter of a ... summer day. , These activities are part of ...
Breaking Medicine News(10 mins):Health News:Scientists Shed Light on Link Between Depression, Dementia 2Health News:Scientists Shed Light on Link Between Depression, Dementia 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 2Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 3Health News:Manchester United vs. Real Madrid Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for Real Madrid vs. ManU Guinness International Champions Cup Match 4Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 2Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 3Health News:Make Kids' Weight Loss a Family Affair, Study Suggests 4
... ... in health care products for Haiti Relief in care of the Lomax Temple African Methodist ... (PRWEB) ... care products for Haiti Relief in care of the Lomax Temple African Methodist Episcopal Zion ...
... , DENVER, CO , Feb. 10 /PRNewswire-FirstCall/ ... MIT ) is pleased to announce that its Chinese Joint ... certification to produce Med-Jet products in China . , ... a recent visit by the SFDA. These facilities were deemed ...
... ... 75% of all New Year’s Resolutions have already failed. The Training Genius Fitness Training ... ... Founder of the Training Genius, Jason Chiero launched his free fitness training website ...
... WHITE PLAINS, N.Y. , Feb. 10 Family history, ... woman,s risk of having a premature baby – but they don,t ... don,t, according to a review article published today in the ... of all disciplines work together and share information – databases, biological ...
... ... In support of first lady Michelle Obama ,s Let,s Move ... a new feature highlighting free educational resources to help teachers and parents educate ... Thinkfinity feature, Let,s Move, includes podcasts, videos, lesson plans and printable worksheets ...
... similar results with less inconvenience, study finds , WEDNESDAY, ... after breast cancer surgery do just as well with ... Canadian study suggests. , "We consider this [finding] a ... the health-care system," said study author Dr. Timothy J. ...
Cached Medicine News:Health News:Binson's Home Health Care Centers Donates over $10,000 for Haiti Relief 2Health News:Major milestone achieved by our joint venture in China 2Health News:Major milestone achieved by our joint venture in China 3Health News:Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series 2Health News:Beat The Odds and Get Back on Track; Revitalizing Fitness Training and Exercise Resolutions With Newly Released, Complimentary Video Series 3Health News:Prevention Is Key Research Goal for Premature Babies, Scientists Say 2Health News:Prevention Is Key Research Goal for Premature Babies, Scientists Say 3Health News:In Support of the 'Let's Move' Campaign to Fight Childhood Obesity, Verizon Thinkfinity Providing Free Educational Resources on Nutrition and Exercise 2Health News:In Support of the 'Let's Move' Campaign to Fight Childhood Obesity, Verizon Thinkfinity Providing Free Educational Resources on Nutrition and Exercise 3Health News:In Support of the 'Let's Move' Campaign to Fight Childhood Obesity, Verizon Thinkfinity Providing Free Educational Resources on Nutrition and Exercise 4Health News:In Support of the 'Let's Move' Campaign to Fight Childhood Obesity, Verizon Thinkfinity Providing Free Educational Resources on Nutrition and Exercise 5Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 2Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 3
The autoclavable, aluminum needle box is designed to store loaded needles and help protect personnel from exposure. Each shield consists of an aluminum box with faceplate to match the grid pattern th...
... The TheraSeed® Pd-103 implant is a combination ... remarkable visibility that makes TheraSeed® treatment an ... can be confident that every TheraSeed® implant ... services which is required by clinicians who ...
... Bard BrachyStar® Needle is designed to help ... and clinically effective brachytherapy procedure. All needles ... tips and polished surfaces for smooth entry ... configurations and sizes assures an ideal match ...
... is designed to help you achieve one ... brachytherapy procedure. All needles are engineered for ... surfaces for smooth entry and exit. A ... assures an ideal match with procedural needs ...
Medicine Products: