Navigation Links
Pivotal Data Published For First Biomarker Combination Test to Determine Risk of Ovarian Cancer in Women Who Present With Pelvic Mass
Date:1/26/2009

his will increase these women's chances of receiving optimal treatment."

The HE4 test and ROMA algorithm are the product of research efforts aimed at identifying combinations of biomarkers to add sensitivity to the existing CA125 test, which is limited in its sensitivity and specificity as well as its ability to detect early stage EOC. The pivotal data provide important validation for the use of the HE4 test in combination with CA125 in estimating EOC risk in women presenting with pelvic mass and, when used in conjunction with other clinical methods, may help to ensure these women receive appropriate treatment.

Dr. Moore and his colleagues conducted a prospective, double-blind, multicenter trial involving 566 women with pelvic mass who were scheduled for surgical intervention. Blood samples were obtained from study participants to measure for levels of HE4 and CA125. Two separate algorithms for premenopausal and postmenopausal women stratified patients into low- and high-risk groups. All patients then underwent surgical removal of the pelvic mass. All tissue specimens were examined to verify the diagnoses made by study site pathologists.

The combination of HE4 and CA125 with the ROMA algorithm was found to be highly accurate in assigning patients to high- and low-risk groups, with 88.7% of EOCs and low malignant potential tumors correctly classified as high-risk. For the postmenopausal group the combination test had a sensitivity of 92.3%, a specificity of 74.7%, and a negative predictive value (NPV) of 92.6%. For the premenopausal group the combination test had a sensitivity of 76.5%, a specificity of 74.8%, and an NPV of 95.0%.

"Research demonstrates that patients who are treated by a gynecologic oncologist fare better than patients who are treated by a non-specialist. Any additional diagnostic tools that help the physician identify who is at a high risk of EOC may result in more optim
'/>"/>

SOURCE Fujirebio Diagnostics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Osteotech Initiates Pivotal Clinical Trial for DuraTech(TM) BioRegeneration Matrix
2. MannKind Corporation to Review Positive Results From Final Two Pivotal Phase 3 Clinical Studies in Type 1 and Type 2 Diabetes
3. Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma
4. Horizon Therapeutics Announces Two Pivotal HZT-501 Phase 3 Trials Meet Primary Endpoints
5. PLC Systems Receives Full FDA Approval for Pivotal Study of RenalGuard(TM) in The U.S.
6. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
7. Cell Therapeutics Pixantrone Phase III (EXTEND) Pivotal Trial Successful in Achieving Primary Endpoint
8. Cell Therapeutics Announces Study Data Set Cut-off for Phase III Pivotal Pixantrone (301) Trial
9. Pivotal Data Showed SYMBICORT(R) Improved Lung Function in Adults with COPD
10. Pivotal Phase III Data Confirm the Efficacy and Safety of Arpidas Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections
11. Sirion Therapeutics Announces Positive Pivotal Uveitis Data for Durezol(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... NEW YORK , July 21, 2014  EHE ... physical exams with a nationwide physician network, today announced ... Las Vegas, NV has been named ... in the Las Vegas region ... to help proactively maintain their health. ...
(Date:7/21/2014)... New York , July 21, 2014 ... report published by Transparency Market Research "E-Clinical Solution Software ... Forecast, 2014 - 2020," the global microfluidic device market ... is expected to grow at a CAGR of 13.8% ... of USD 6,515.3 million in 2020. Browse ...
(Date:7/21/2014)... LAS VEGAS , July 21, 2014 By ... Division will conduct an online sale of ophthalmic and optical ... Las Vegas -based eyewear specialists American Optical Services LLC. ... and will close in rapid succession, live auction style, ... the various assets being offered will be held July 25 ...
Breaking Medicine Technology:EHE International Certifies Dignity Health Medical Group Nevada, LLC as Its Newest Partner 2E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 2E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 3E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 4E-Clinical Solution Software Market is expected to reach USD 6,515.3 million in 2020: Transparency Market Research 5Auction Set For Assets Of National Optical Services Company 2
(Date:7/22/2014)... 22, 2014 Dr. Allen Kamrava, colorectal ... launch of a new website dedicated to the diagnosis ... be found at DrKamrava.com . , “With this ... a knowledgeable and trustworthy source for various colorectal ... hemorrhoids, fissures, gallstones, colon cancer, hernias, or more, patients ...
(Date:7/22/2014)... Angeles, CA (PRWEB) July 22, 2014 ... online marketing training course that takes a comprehensive, step-by-step ... scale an online marketing venture has just been released ... Hendricks. , “In the internet marketing world if you’re ... Hendricks. “And a lot of people simply give up ...
(Date:7/22/2014)... 2014 Eating certain foods can not only ... according to two of the world’s top cosmetic dentists. ... of the Anacapa Dental Art Institute in Oxnard and Woodland ... of one’s teeth. They are specially trained to replace missing ... not seeing a dentist regularly, and about two-thirds of the ...
(Date:7/22/2014)... Kirby Lester, LLC, the leading pharmacy automation ... functionality to perform a trackable double-count for any prescription ... double-count of controlled medications is required, the KL1Plus allows ... a second count of any tablet or capsule order. ... second count up to 10 years. This function is ...
(Date:7/22/2014)... 22, 2014 Industry-leading health business information ... release of Specialty Pharmacy Trends and Strategies: 2014 ... provides a comprehensive overview of the current state of ... strategies and tactics for:, , Specialty ... utilization concerns — including details of coinsurance levels by ...
Breaking Medicine News(10 mins):Health News:Los Angeles Doctor Launches Brand New Website for Colorectal Surgery and Treatment 2Health News:Los Angeles Doctor Launches Brand New Website for Colorectal Surgery and Treatment 3Health News:Info Cash 2.0: Review Of Chris Carpenter’s Online Marketing Training Released 2Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 2Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 3Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 4Health News:Ventura’s Best Cosmetic Dentists Offer 4 Tips for Improving Dental Health Through Nutrition 5Health News:Kirby Lester KL1Plus Pharmacy Automation Perfect for Double-Counting & Tracking Prescriptions from Any Pharmacy Robot 2Health News:Latest Edition of Annual Book Provides Comprehensive Overview of the Specialty Pharmacy Arena 2
... declined dramatically after the establishment of North America,s first ... the findings of a groundbreaking new study published in ... first peer-reviewed study to assess the impact of supervised ... reduction in overdose deaths in the immediate vicinity of ...
... , THURSDAY, April 21 (HealthDay News) -- For men ... don,t measure up -- success can be found in ... by Italian researchers contends. Concerned that patients were ... the penis, the researchers examined the medical literature to ...
... obese adolescents are no more likely to be depressed than ... online in the Journal of Adolescent Health , did ... psychological effects of obesity. This three-year study performed ... Policy at MassGeneral Hospital for Children (MGHfC) and the Department ...
... 21 (HealthDay News) -- Long-term use of topical corticosteroids to ... cause any major negative side effects, according to a new ... corticosteroid creams or lotions applied to the skin and this ... explained. The most common fear among parents is that these ...
... Dotinga HealthDay Reporter , THURSDAY, April 21 (HealthDay ... exposure to a class of pesticides widely used on food ... is especially noticeable in kids from a California farming region ... pesticides through their use on local crops. ...
... effects of mindfulness meditation on pain and working memory ... crucial brain wave called the alpha rhythm. This rhythm ... information, which suggests that a key value of meditation ... world. Researchers from Massachusetts General Hospital (MGH), Harvard Medical ...
Cached Medicine News:Health News:Deaths from drug overdose decline 35 percent after the opening of supervised injection site 2Health News:When Size Matters, Men Can Turn to Penile Extenders: Study 2Health News:When Size Matters, Men Can Turn to Penile Extenders: Study 3Health News:Severe obesity not seen to increase risk of depression in teens 2Health News:Corticosteroid Creams Safe for Kids With Eczema: Study 2Health News:Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids 2Health News:Pesticide Exposure in Pregnancy Linked to Lower IQ in Kids 3Health News:Meditation may help the brain 'turn down the volume' on distractions 2Health News:Meditation may help the brain 'turn down the volume' on distractions 3