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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

e shown encouraging survival results associated with Avastin, however, the risk of gastrointestinal perforations and bleeding remains a major concern 110

SWOT analysis 111

Datamonitor drug assessment scorecard for Avastin 112

Clinical and commercial attractiveness 113

Failure of the Phase III AVAGAST study to meet its primary endpoints in first-line metastatic gastric cancer is a setback... 113

...although Avastin could still have a role in resectable gastric cancer 114

Roche's leading position in the oncology market will almost certainly result in success 114

Increasingly cost-conservative healthcare systems could restrict potential uptake of Avastin 114

Satisfaction of unmet needs 115

Forecasts to 2019 115

Erbitux (cetuximab; Eli Lilly/Bristol-Myers Squibb/Merck KGaA) 116

Drug overview 116

Drug profile 116

Key historical events 117

Clinical trial data 118

Several Phase II studies have shown encouraging survival results associated with Erbitux, with a potential tumor response correlation linked to incidence of acneiform rash 119

SWOT analysis 120

Datamonitor drug assessment scorecard for Erbitux 121

Clinical and commercial attractiveness 122

Phase II data show a comparable response rate to the current first-line standard, but the Phase III EXPAND trial will need to demonstrate superior overall survival 122

Erbitux's cost may hinder its uptake in certain markets... 122

...although if use is targeted to specific patient subtypes, then the issue of cost may be overcome 123

Satisfaction of unmet needs 123

Forecasts to 2019 124

Afinitor (everolimus; Novartis) 125

Drug overview 125

Drug profile 125

Key historical events 126

Clinical trial data 127

Phase II results showed 0% overall response rate, but a very encouraging median overall survival of 10.1 months in heavily pre
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