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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

ets 84

Rest of the world 87

Current treatment options 88

Current comparator therapy 90

Taxotere (docetaxel; Sanofi-Aventis) 90

Unmet need in gastric cancer 91

Lack of effective systemic therapy 92

Poorly defined standard treatment regimens 92

Poor control of distant metastases 93

Complete lack of second-line options 93

Target product profile versus current level of attainment 93

Pipeline analysis and forecasts 94

Pipeline summary 94

Comparative forecasts 96

Herceptin (trastuzumab; Genentech/Roche/Chugai) 99

Drug overview 99

Drug profile 99

Key historical events 100

Clinical trial data 101

Phase III ToGA study shows the addition of Herceptin to first-line chemotherapy to result in a 2.7 month survival benefit in HER-2-positive metastatic gastric cancer 102

SWOT analysis 103

Datamonitor drug assessment scorecard for Herceptin 103

Clinical and commercial attractiveness 104

Herceptin is the first molecular targeted therapy to gain approval for gastric cancer 104

Targeting HER-2-positive patients specifically is in line with the trend for more personalized therapy... 104

...however, restricts Herceptin's commercial potential in gastric cancer 105

Tykerb could pose a competitive threat to Herceptin 105

Concerns exist over Herceptin's association with cardiotoxicity 105

Roche's leading position in the oncology market will almost certainly lead to success 106

Satisfaction of unmet needs 106

Forecasts to 2019 106

Avastin (bevacizumab; Genentech/Roche/Chugai) 107

Drug overview 107

Drug profile 107

Key historical events 108

Clinical trial data 110

The Phase III AVAGAST study failed to meet its primary endpoint of improving overall survival in the first-line metastatic gastric cancer setting 110

Several Phase II studies hav
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