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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

ncer 66

Earlier diagnosis could improve prognosis of esophageal cancer 67

New and more effective systemic therapies for advanced disease are required 68

More effective neoadjuvant and/or adjuvant therapy to reduce relapse rates 68

More large-scale, randomized clinical trials are necessary to define optimal treatment strategies 68

Target product profile versus current level of attainment 69

Pipeline analysis and forecasts 70

Pipeline summary 70

Comparative forecasts 72

Tykerb (lapatinib; GlaxoSmithKline) 73

Drug overview 73

Drug profile 73

Key historical events 74

Clinical trial data 75

One Phase II trial has shown minimal activity in second-line metastatic esophageal cancer, and two Phase II studies have been terminated to date 76

SWOT analysis 76

Datamonitor drug assessment scorecard for Tykerb 77

Clinical and commercial attractiveness 78

Minimal clinical data have been reported for Tykerb in esophageal cancer, making it difficult to judge its clinical attractiveness 78

EGFR inhibition is a popular strategy for gastrointestinal tumors, but experience in esophageal cancer has been dubious so far 79

HER-2 inhibition is a rarer strategy, although has proven successful in gastric cancer 79

Concerns exist over Tykerb's association with hepatotoxicity 79

Tykerb's oral formulation may prove problematic... 80

...however, it could become the first approved therapy for esophageal cancer 80

Satisfaction of unmet needs 80

Forecasts to 2019 81

5. Gastric Cancer 82

Key findings 82

Disease overview 82

Definition 82

Gastric cancer is the second most common tumor type on a global scale 82

Patient segmentation 83

A more detailed Japanese staging system exists for gastric cancer, but is not used in the US or Europe 83

Epidemiology 84

Seven major mark
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