Navigation Links
Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

Unmet need in colorectal cancer 27

Better screening approaches needed to decrease mortality rates 28

More effective therapies are needed in both early-stage and advanced disease 28

Biomarkers and the selection of patients may help improve outcomes 29

Target product profile versus current level of attainment 30

Pipeline analysis and forecasts 31

Pipeline summary 31

Comparative forecasts 33

Aflibercept (VEGF-Trap; Regeneron/Sanofi-Aventis) 35

Drug overview 35

Drug profile 35

Key historical events 36

Clinical trial data 37

Phase II results show aflibercept to confer better antitumor activity in patients previously treated with Avastin 38

SWOT analysis 38

Datamonitor drug assessment scorecard for aflibercept 39

Clinical and commercial attractiveness 40

Aflibercept's primary development in second-line colorectal cancer means direct competition with Avastin in the first-line setting can be avoided... 40

...although several factors may hamper aflibercept's uptake in the second-line setting 41

Aflibercept still needs to differentiate itself from other angiogenesis inhibitors in development for colorectal cancer 41

Presence in colorectal cancer will aid commercialization of aflibercept 41

Satisfaction of unmet needs 41

Forecasts to 2019 42

Brivanib (BMS-582664; Bristol-Myers Squibb) 43

Drug overview 43

Drug profile 43

Key historical events 44

Clinical trial data 45

Phase I/II results show brivanib to confer better clinical benefit in patients with wild-type KRAS tumors 45

SWOT analysis 46

Datamonitor drug assessment scorecard for brivanib 47

Clinical and commercial attractiveness 47

Better clinical benefit in wild-type KRAS tumors could boost brivanib's apparent efficacy in second-line colorectal cancer 47

Economic evaluation is an encouraging
'/>"/>

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

Related medicine technology :

1. Karyopharm Therapeutics Inc. Closes $20 Million Series A Financing to Advance Pipeline of Novel Nuclear Transport Modulators for Cancer, Inflammation and Other Disorders
2. Tengion Reviews Pipeline Progress at First Analyst and Investor Meeting; Strategic & Clinical Updates Provided for Regenerative Medicine Programs
3. Lexicon to Provide Clinical Pipeline Update and Report Third Quarter 2010 Financial Results
4. Reportlinker Adds Commercializing Cancer Vaccines: A Decision Support Tool for Optimizing the Pipeline
5. Emerging Cancer Vaccines Market: Forecasts, Developments and Pipeline Analysis, 4th Edition Now Available at ReportsandReports
6. Updated Pfizer Pipeline Focuses on Value, Unmet Medical Need
7. Reportlinker Adds Electrophysiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016
8. Reportlinker Adds Prosthetic Heart Valves - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016
9. Abbott to Present Data on Market-Leading XIENCE V® and Promising Vascular Pipeline at TCT 2010
10. Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016
11. Reportlinker Adds Global Renal Dialysis Equipment Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... 27, 2015  The Academy of Managed Care ... Administration,s (FDA,s) draft guidance and proposed rule that ... to bear a nonproprietary name with an FDA-designated ... a decision from the FDA on the naming ... stakeholders urging the agency to use the same ...
(Date:8/27/2015)... , Aug. 27, 2015  A recent ... KSSTA Knee Journal, compared the Arthrosurface HemiCAP® Wave ... design, versus an "onlay" design implant for isolated ... improvements in function and pain scores, none of ... of osteoarthritis (OA). However, 53% of the patients ...
(Date:8/27/2015)... CUPERTINO, Calif. , Aug. 27, 2015 ... management is scheduled to present at three upcoming healthcare ... , President and CEO, will present at the Rodman ... 10:00 a.m. Eastern time. The conference is being held ... York City . A live audio webcast of ...
Breaking Medicine Technology:AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3DURECT to Participate in Upcoming Healthcare Conferences 2
... ALR ), a global leader in enabling ... through the merger of rapid diagnostics and health management, ... JMP Securities Healthcare Conference being held September 27 through ... Avenue, New York.  Jon Russell, Vice President, Finance, will ...
... ALR ) announced today that, in connection with its ... it entered into a purchase agreement with the initial purchasers ... the offering was increased from $350.0 million to $400.0 million. ... offered at 100.0% of the aggregate principal amount of the ...
Cached Medicine Technology:Alere Inc. Announces Pricing of Senior Subordinated Notes Offering; Offering Size Increased to $400.0 Million 2
(Date:8/28/2015)... ... August 28, 2015 , ... The ... consolidated as MDL 2545, Testosterone Replacement Therapy Products Liability Litigation, are in the ... of custodial files the PSC may receive for corporate employees involved in the ...
(Date:8/28/2015)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, ... in order to ease the stress on the atmosphere, and lessen the number and ... the real cause of global warming and urges them to look into his studies ...
(Date:8/28/2015)... Knoxville, TN (PRWEB) , ... August 28, 2015 , ... ... surrounding the Centers for Medicare & Medicaid Services’ (CMS) proposal to mandate bundled ... 45-minute webinar , “Get Ready for Game Day: Comprehensive Care for Joint Replacement,” ...
(Date:8/28/2015)... , ... August 28, 2015 , ... Inc. magazine today ... list, an exclusive ranking of the nation’s fastest-growing private companies. The list was unveiled ... sales growth of 85% over the last three years, PREVENT ranks higher on the ...
(Date:8/28/2015)... ... ... launched their new website this summer. The new user-friendly site has a ... design. Website users will now have an improved browsing experience on their phones, tablets, ... the monthly turf-tips email, and find a local Super-Sod store all from the convenience ...
Breaking Medicine News(10 mins):Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 3Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 4Health News:Wake Up and Smell the Sick Atmosphere Says Yisrayl Hawkins in New Article This Week 2Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3Health News:PREVENT Life Safety Ranks No. 3660 on the 2015 Inc. 5000 With Three-Year Sales Growth of 85% 2
... , , WASHINGTON , Jan. 27 ... the National Viral Hepatitis Roundtable (NVHR) issued the following ... Address.  NVHR is a coalition of more than 150 public, ... infection, morbidity, and mortality from chronic viral hepatitis that afflicts ...
... , 30 Groups Emphasize The Urgency Of ... Thousands of Americans , WASHINGTON , ... consumers, health professionals and providers recently sent a letter ... the exceptions process for Medicare Part B outpatient therapy ...
... from a team at the Providence Heart + Lung Institute ... (UBC) may lead to new treatment options for abdominal aortic ... no pharmacological treatments. An aortic aneurysm is a bulging ... If the aneurysm ruptures, it causes rapid blood loss and ...
... with end-stage kidney disease suffer physical, social, emotional and ... Hopkins Children,s Center shows that even mild to moderate ... life. The findings, reported in the February issue ... quality-of-life issues in children with chronic kidney disease is ...
... higher cost-sharing for outpatient visits may increase overall spending ... for doctor visits and other outpatient care reduces seniors, ... the unintended consequence of sharply increasing hospitalizations, a new ... inflating overall health-care spending and put vulnerable elderly at ...
... , ... breast cancer charity partners with the Vehicle Donation Processing Center to provide financial assistance ... ... (TBCS) has partnered with the Vehicle Donation Processing Center, Inc. to launch a vehicle ...
Cached Medicine News:Health News:NVHR Issues Challenge to Administration, Congress: Don't Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze 2Health News:NVHR Issues Challenge to Administration, Congress: Don't Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze 3Health News:Congress Urged to Take Immediate Action to Ensure Frail Patients Continue to Receive Critical Therapy Services 2Health News:Congress Urged to Take Immediate Action to Ensure Frail Patients Continue to Receive Critical Therapy Services 3Health News:Discovery points way for new treatment for aneurysms: UBC-Providence Research 2Health News:Even mild kidney disease harms a child's quality of life 2Health News:Raising Co-Pays for Doctor Visits Raises Seniors' Hospital Use 2Health News:Raising Co-Pays for Doctor Visits Raises Seniors' Hospital Use 3Health News: The Breast Cancer Society Launches Vehicle Donation Program 2Health News: The Breast Cancer Society Launches Vehicle Donation Program 3
... Solution For Your Tracheostomy Care Needs, ... features the latest components for efficient and ... task. Designed by clinicians, these latex-free trays ... patient and caregiver. All of our trays ...
... Right Solution For Your Tracheostomy Care Needs, ... tray features the latest components for efficient ... control task. Designed by clinicians, these latex-free ... each patient and caregiver. All of our ...
... Kendall provides hospitals and alternate care ... tracheostomy care trays which offer the ... control. Designed with the guidance of ... trays provide exactly what is required ...
For use with cushioned neckband....
Medicine Products: