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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

Unmet need in colorectal cancer 27

Better screening approaches needed to decrease mortality rates 28

More effective therapies are needed in both early-stage and advanced disease 28

Biomarkers and the selection of patients may help improve outcomes 29

Target product profile versus current level of attainment 30

Pipeline analysis and forecasts 31

Pipeline summary 31

Comparative forecasts 33

Aflibercept (VEGF-Trap; Regeneron/Sanofi-Aventis) 35

Drug overview 35

Drug profile 35

Key historical events 36

Clinical trial data 37

Phase II results show aflibercept to confer better antitumor activity in patients previously treated with Avastin 38

SWOT analysis 38

Datamonitor drug assessment scorecard for aflibercept 39

Clinical and commercial attractiveness 40

Aflibercept's primary development in second-line colorectal cancer means direct competition with Avastin in the first-line setting can be avoided... 40

...although several factors may hamper aflibercept's uptake in the second-line setting 41

Aflibercept still needs to differentiate itself from other angiogenesis inhibitors in development for colorectal cancer 41

Presence in colorectal cancer will aid commercialization of aflibercept 41

Satisfaction of unmet needs 41

Forecasts to 2019 42

Brivanib (BMS-582664; Bristol-Myers Squibb) 43

Drug overview 43

Drug profile 43

Key historical events 44

Clinical trial data 45

Phase I/II results show brivanib to confer better clinical benefit in patients with wild-type KRAS tumors 45

SWOT analysis 46

Datamonitor drug assessment scorecard for brivanib 47

Clinical and commercial attractiveness 47

Better clinical benefit in wild-type KRAS tumors could boost brivanib's apparent efficacy in second-line colorectal cancer 47

Economic evaluation is an encouraging
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