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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

ase gastrointestinal cancers pipeline 7

Pancreatic cancer has emerged as a popular R&D target due to a significant level of unmet need which could result in high commercial reward 9

Comparative forecasts 10

Key companies involved in the gastrointestinal cancers pipeline 11

Amgen 11

Eli Lilly 12

Roche 13

Key R&D company strategies 15

The metastatic gastrointestinal cancer population holds the most commercial potential, with the highest levels of unmet need in the second-line setting for some tumor types 15

The inclusion of molecular targeted therapies into treatment of gastrointestinal cancers appears to be the way forward 15

2. R&D Approach 16

Key findings 16

Clinical trial design in gastrointestinal cancers 16

Patient selection 16

Increasingly significant in the era of targeted treatment 16

Clinical trial duration 17

Sufficient follow-up is necessary to establish true clinical benefit 17

The advent of novel therapies 17

Diversity of targeted therapies will require an evolution in clinical trial design 17

Clinical trial endpoints in gastrointestinal cancers 18

Most oncology clinical trials designate multiple endpoints 18

Survival 18

Quality of life 18

Tumor response rates 18

Toxicity 19

Time to tumor progression 19

3. Colorectal Cancer 20

Key findings 20

Disease overview 20

Definition 20

Colorectal cancer is the third most common tumor type and cause of cancer-related death in both men and women 20

Patient segmentation 21

The American Joint Committee on Cancer TNM classification system has replaced the older Dukes staging system 21

Epidemiology 21

Seven major markets 21

Rest of the world 23

Current treatment options 24

Current comparator therapy 27

Eloxatin (oxaliplatin; Sanofi-Aventis) 27


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